1905 movie network news On the evening of December 22, Jiaxing Media, the brokerage company to which Yang Mi and Liu Kaiwei belong, issued a statement announcing that Yang Mi and Liu Kaiwei had signed an agreement in 2018 to peacefully break up and end their marriage.

In the statement, it also specifically stated that "although they will no longer live together as husband and wife, the two will also take care of and raise the children together as relatives in the future." To put an end to the small glutinous rice issue that the majority of netizens are concerned about.

In 2011, Yang Mi and Liu Kaiwei fell in love for the filming of the TV series "Ruyi". In 2012, the two admitted to their relationship on Weibo. On January 8, 2014, Yang Mi and Liu Kaiwei held a wedding ceremony in Bali; on January 19 of the same year, Liu Kaiwei confirmed that Yang Mi was more than three months pregnant. On June 1, 2014, Yang Mi gave birth to her daughter "Xiao Nuomi" in Hong Kong.

In the two years after their marriage, Yang Mi and Liu Kaiwei interacted frequently, and the two often forwarded and interacted sweetly with each other on Weibo. But since 2016, the interaction between the two sides on Weibo has become less and less. In the past two or three years, both of them have produced a lot of new works, but the two sides have almost never promoted each other. On December 3, 2015, Liu Kaiwei forwarded Yang Mi’s new works for the last time. And at the end of 2015, it was when Liu Kaiwei and Yang Mi reported that their marriage was changing.

Until 2018, the two’s Weibo almost stopped interacting. The last time Liu Kaiwei interacted with Yang Mi on Weibo was on April 12, 2018. Yang Mi was caught in a public welfare scam, and Liu Kaiwei forwarded the rumor-refuting article and supported Yang Mi.

And according to an online friend, "It has been rumored for so long, why did Liu Kaiwei and Yang Mi choose to announce the divorce statement today? Because schools in Hong Kong will give students a Christmas holiday from December 22, and the holiday time is not short. In order to protect Xiao Nuomi from being chased by the media, the two of them advised everyone not to disturb Xiao Nuomi."

Click to watch more video highlights of Star Jump > >

Killer took off handstand.

Xing Aowei takes off.

Gao Hu’s Flying Swallow Action

　　Zhejiang Satellite TV’s large-scale charity star diving reality show "China Star Jump", since last week’s transfer to the semi-finals of the master’s tricks, the overall difficulty of the players’ jumping has improved, and the difficulty of the movements has erupted collectively. Especially in Gao Hu and Killer, two "high-platform kings" jumped out of the amazing professional-level movements. Killer took out the difficult movement of 611A handstand and somersaulted forward for half a week in the first jump, and then challenged the highest difficulty 202A of the 10-meter platform since the launch of the diving program, while Gao Hu 302C’s perfect jump of reflexively somersaulted and hugged her knees for one week, which was praised by Olympic champion Li Na, a substitute judge, as "the height that professional athletes can only reach after practicing for one year". This week’s second semi-final is still full of experts, especially Xing Aowei, the Olympic gymnastics champion of cross-border diving, who created a dazzling 720-degree somersault and a 180-degree twist against the sky in the preliminary round. The semi-final will continue to carry forward the spirit of innovation and threatened to "jump the diving action of the next Olympic Games" if he advanced to the final.

　　Killer, Xing Aowei and Gao Hu, who are also non-professional divers, have turned from inexperienced diving novices to almost professional ones. Their respective advantages of "being in harmony with the right time and the right people" are prominent, which is an important weight for their successful breakthrough and the secret behind their successful counterattack.

　　Location: Gao Hu grew up facing the sea, and his childhood "plunge" warmed up and dived.

　　Gao Hu is the "king of the platform" among the contestants. He not only won the 10m platform at the fastest speed in training, but also was the first person in the competition. In addition to the courage and boldness of "being too high to be happy", Gao Hu showed an amazing and perfect swallow in the preliminary round, and the difficulty of the action was also upgraded all the way. Especially in the last semi-final, Gao Hu 302C made a perfect jump by doing a reverse somersault and holding her knees for a week. Even Olympic champion judge Li Na praised this as "the height that professional players can only reach after practicing for one year". He also relied on this difficult and perfect jump to sit firmly on the spot and advance directly to the final without any suspense.

　　The reason why Gao Hu achieved such amazing diving attainments in a short time can be said to be due to the "geographical advantage" occupied since childhood. He is a native of Qingdao, and the urban environment surrounded by the sea on three sides gives Gao Hu a unique advantage before diving. According to Gao Hu himself, "I grew up facing the sea, and I have a deep plot about water. My whole family likes swimming very much, so I have been moving freely in the water since I was three or four years old". According to Gao Hu’s recollection, there are many hills and rocks in his hometown near Qingdao. When he was a child, he was bold. He often avoided his parents’ attention with his friends and jumped from the rocks to the water for excitement. Although the equipment was rudimentary and there was no technical content, his childhood experience was similar to that of today’s diving, especially because he learned Gao Hu’s boldness. It is no wonder that he was able to walk calmly on the 10-meter platform on the first day of training. He once said that "I am not afraid of heights at all and like to challenge the limits." Gao Hu, who has excellent water quality, also revealed that he had passed the diving certificate when he traveled to Palau.

　　In addition, Gao Hu is also a sportsman. He likes to play volleyball since he was a child. He is the leader of the school volleyball team. He has participated in many municipal competitions with the team, and volleyball has also trained Gao Hu’s good arm strength.

　　Timing: Killer was born with good gene dance skills and was born with boldness.

　　Killer has been called "Zhang Dadan" since she entered the competition. In the preliminary competition, she was the first woman on the 10m platform, which was as famous as Gao Hu. In the semi-finals, she was even more powerful, with two consecutive jumps. The first jump of 611A turned upside down for half a week, becoming the first woman to use platform handstand, while the second jump of 202A turned backwards for a week, which was the highest difficulty since the diving program was launched.

　　The reason why Killer dives so well can be said that she won at the starting line because of her favorable weather and natural genes. Killer’s mother is a dance teacher, and her innate motor genes, coupled with the super-high physical flexibility of practicing dance since childhood, give her obvious advantages in diving. In addition, Killer, who is bold by nature, also said that he was particularly love the water and liked swimming since childhood. This boldness surprised everyone when Killer walked into the diving hall for the first time, and immediately won the 10m platform, giving the competitors a modest "duel". In a daily training, the diving hall was suddenly cut off due to an accident, and it was suddenly plunged into darkness. At that time, the staff and players present, especially the girls, screamed with fear and scrambled to climb ashore from the water. At that time, Killer, who was on the shore, jumped into the water and swam in the dark diving hall, exclaiming that "such an opportunity is too rare, swimming in the dark is very exciting", which attracted Gao Hu present to be outdone and jumped into the water.

　　People and Peace: Coach Xing Aowei and the judges all found that small gymnastics and diving are connected.

　　As the Olympic champion of gymnastics, Xing Aowei still can’t hide the champion’s potential in cross-border diving. In addition to his amazing jump in the preliminary round, he let the audience see the high platform handstand for the first time, and even created a dazzling "anti-heaven" action in the second jump: 720-degree somersault and 180-degree turn, which caused a full house of applause. This action is even more created by Xing Aowei. In the semi-finals, he said that he would continue to carry forward the spirit of innovation, and he confidently threatened to "jump the diving action of the next Olympic Games" if he could advance to the final.

　　Xing Aowei has the highest starting line among all the players. As a gymnast of the national gymnastics team and an Olympic gold medal champion, he stood out among all the players from the first day of training. The national diving team and the gymnastics team are veritable neighbors. They used to practice in the same training hall. Therefore, many national diving team members and Xing Aowei have been good friends since childhood, including Li Na, the world diving champion who is the coach in this competition. Therefore, Xing Aowei has no pressure and a sense of formality in the training process. Although gymnastics and diving are two completely different sports, they have a lot in common, especially turning and tumbling, which is why Li Xiaopeng of Prince of gymnastics was specially invited to the jury, and Li Xiaopeng’s position was to comment on diving from a semi-professional perspective. Xing Aowei and Li Xiaopeng are both Olympic champions. Since Li Xiaopeng can be a judge, it can be seen that Xing Aowei’s starting line is high, and their teammates, especially good brothers, let him score in the judges’ scoring.

　　Pay more attention to "China Star Jump" official website: http://www.zjstv.com/splash

　

Fast Technology News on June 18, the latest data released by Qjie Automobile shows that,From January 1st to June 16th, the new M7 sold 100,900 units, topping the top 1 sales list of new power models in the Chinese market.Become the first new power model to exceed 100,000 sales in 2024.

The recently released 2024 China New Power Model Sales List includes statistics on the sales of new power models from January to June this year.

The list shows that as of June 9,The annual cumulative sales of the new M7 series models have reached 96,500 units, and the cliff-type leading ideal L7, polar krypton 001 and other new power models have won the first half of 2024 China’s new power sales crown.

At the same time, the newly upgraded "National SUV" asked Jiexin M7 Ultra, with deliveries exceeding 4,349 units in the first week of listing, setting a new power model delivery record in China.

Other models in the list, the ideal L7 ranked second with 56,600 vehicles; the polar krypton 001 ranked third for 42,000 vehicles.

This is also equivalent to,The sales of the new M7 in the world have almost reached the sum of the second and third place, indicating the leading advantage of the new M7 in the world.

It is reported that the new M7 Ultra was launched on May 31, with a total of four models, priced at 28.98-32 9,800 yuan.

The new car is equipped with Huawei’s latest 192-line lidar (the same model as the M9) as standard, which is currently the highest number of line lidar in mass production. With Huawei’s mature ADS 2.0 high-end intelligent driving, there are few competitors in the same level of intelligent driving experience.

And ask the new M7 Ultra’s 35,000 yuan limited-time car purchase rights will end on June 30. It is expected that by the end of June, the order volume of the new M7 will have a big outbreak.

According to the China Fund, the pace of capitalization of the new car-making forces has obviously accelerated, and this time it is Li Shufu’s turn to be a krypton car.

On February 13th, Geely Holding (00175.HK) announced in the morning that it issued and distributed about 139 million Series A preferred shares to five investors, raising a total of 750 million US dollars (equivalent to 5.09 billion RMB). Among them, Contemporary Amperex Technology Co., Limited (300750), which has invested in the Pre-A round, has increased its price again, which shows that it is optimistic about this new force.

After completing this round of financing, the valuation of Krypton has reached 13 billion US dollars (about 88.23 billion yuan). It is understood that this valuation amount also exceeds the valuation level before landing in the IPO of the US stock "Wei Xiaoli" in the early years. As early as the end of last year, Geely publicly announced that it planned to split the IPO of Extreme Krypton in the United States, and this new force in making cars is also expected to become the first new energy vehicle company listed this year.

Contemporary Amperex Technology Co., Limited participated in the second vote.

Extreme Krypton Automobile announced the first heavyweight financing of the new energy automobile industry this year. According to the announcement of Geely Holding, Extreme Krypton entered into a share purchase agreement with five investors on February 12. Accordingly, five investors agreed to subscribe and purchase from Krypton, and Krypton agreed to issue and distribute a total of 139 million Series A preferred shares to five investors at a total consideration of 750 million US dollars.

It should be pointed out that the investors participating in this financing are Amnon Shashua, founder of Mobileye Global Inc, Contemporary Amperex Technology Co., Limited, Yuexiu Industrial Fund, Trading Fund and Xin An Zhi Fund. According to Krypton, after the completion of this A round of financing, the valuation of Krypton is about 13 billion US dollars.

This amount also exceeds the pre-IPO valuation of the three new car-making forces "Wei Xiaoli" that have been listed in the United States. The highest valuations of the above three companies were about $6.4 billion, $8.6 billion and $8.8 billion before the US stock market was issued.

Judging from the institutions participating in this round of financing, Contemporary Amperex Technology Co., Limited is not only a long-term strategic partner of Krypton, but also an additional investment in this round to further deepen cooperation. As early as August, 2021, Contemporary Amperex Technology Co., Limited participated in the Pre-A financing of Krypton cars. In addition to Contemporary Amperex Technology Co., Limited, the participating institutions in this round include Yuexiu Industrial Fund, Trade Fund and Quzhou Trust An Zhi Fund. According to Krypton, the above three companies will help Krypton integrate its rich industrial resources and help it further expand in the upstream and downstream of the industrial chain.

According to the announcement, immediately after the delivery, Geely Holding will hold approximately 54.73% (calculated on the converted basis) and approximately 51.33% (calculated on the fully diluted and converted basis). Krypton will remain an indirect non-wholly-owned subsidiary of Geely Holding, and its financial performance will continue to be incorporated into the Group’s consolidated financial statements.

According to Krypton, the funds raised this time will be mainly used for research and development of Krypton products and technologies, global business development and user experience improvement. The company said that the five investment institutions have rich industrial resources in their respective fields, especially in smart driving, power batteries, innovative materials and high-end equipment manufacturing.

Or the fastest IPO case in the cost round

In March 2021, Extreme Krypton Automobile was jointly invested and established by Geely Automobile and Geely Holding Group. Geely has also given high hopes to the extremely krypton car.

The data shows that Krypton delivered a total of 71,900 vehicles last year, and completed the sales target of 70,000 vehicles in 2022 ahead of schedule in mid-December. According to the expectation of Geely Holding Group, by 2025, the sales volume of extremely krypton vehicles will reach 650,000, ranking the top three in the world in the market share of high-end electric vehicles. Moreover, the sales performance of Krypton is completely supported by the single model Krypton 001, so the annual sales of Krypton are quite valuable.

In terms of financing, Krypton Auto completed the Pre-A round of financing with a total of US$ 500 million from Intel Capital, Contemporary Amperex Technology Co., Limited, Bili Bili, Hongshang Group and Boyu Investment in August of that year. According to the financing situation at that time, the valuation of Extreme Krypton was about $9 billion.

In December last year, Geely Holding publicly announced that on December 7, 2022, Krypton submitted a draft registration statement for possible initial public offering to the US Securities and Exchange Commission on a confidential basis. The proposed spin-off currently includes two items, namely, the sale of krypton shares in the United States and the distribution of American Depositary Shares to shareholders in kind.

Earlier, it was reported that Krypton sought to raise more than $1 billion in the United States, with a valuation of more than $10 billion, which was higher than the valuation of $9 billion when it raised funds for the first time in 2021. However, according to the valuation of this A round of financing, this amount has far exceeded previous expectations. And this new car-making force was established only less than two years ago.

It is widely speculated in the market that Krypton will be listed as soon as possible in the second quarter of this year, so it is also considered to be the most likely car company to be listed first in this round.

Years of losses to accelerate financing.

Recently, the pace of capitalization of new car-making forces is accelerating. At the beginning of this month, Hezhong Automobile behind Nezha Automobile completed the shareholding system change, which was understood by the market as accelerating the IPO. Ai’ an, a subsidiary of Guangzhou Automobile Group, also explicitly called out the IPO in 2023.

These new forces have a common feature, that is, they are in a state of loss for years. Even "Wei Xiaoli", whose sales volume has climbed and gross profit margin has turned positive, has not yet achieved profitability under the continuous R&D investment and market layout. Ceng Qinghong, chairman of Guangzhou Automobile Group, once bluntly said, "Except for Tesla, all new energy automakers are losing money and have no money to earn. This is a consensus."

In 2021 alone, the loss of Ai ‘an, which has been valued at over 100 billion yuan, reached 1.389 billion yuan, with a year-on-year increase of 101.95%. In 2019 -2021, the losses of Ai ‘an were 621 million yuan, 688 million yuan and 1.389 billion yuan respectively, with a cumulative loss of 2.698 billion yuan in three years. In 2020, the net loss of Nezha Automobile reached 1.321 billion yuan, and in 2021, its net loss expanded to 2.908 billion yuan.

Krypton cars can’t escape this fate. According to the previously published financial report data of Geely Convenience, the revenue in 2021 was 2.868 billion yuan, and the net loss in the same period reached 1.01 billion yuan; In the first half of 2022, the revenue of Krypton was 8.828 billion yuan, and the net loss during the period was 759 million yuan. Since the establishment of the brand, the accumulated net loss of Krypton is nearly 1.8 billion yuan.

The gross profit margin of this new car-making force was around 5% in the first half of last year. The gross profit margins of LI, Xpeng Motors and Weilai were 22.09%, 11.55% and 13.8% respectively.

Original title: the valuation is nearly 90 billion! Li Shufu is on fire again, Ning Wang is overweight!

Editor: Zheng Yalan

Editor: Zhang Songtao

Audit: Feng Fei

foreword

Malignant multiple myeloma(multiple myeloma ； MM) is a kind ofwithMalignant disease characterized by massive proliferation of monoclonal plasma cells in bone marrow. B cell maturation antigen (BCMA) is highly expressed on the surface of MM cells. In the past few years, great progress has been made in various BCMA targeted immunotherapy for recurrent/refractory MM patients, including anti-BCMA monoclonal antibodies, antibody-drug conjugates (ADC), bispecific T cell binders (BITE) and chimeric antigen receptor adoptive T cell therapy (CAR-T). The 63rd annual meeting of American Hematology Society updated some information about the application of BCMA in MM, and based on this annual meeting, the related contents of this paper were sorted out [1].

Immunotherapy targeting BCMA: (1)ADC; 　 (2)CAR-T; 　 (3)BiTE;　

copywriter |　NING

BCell maturation antigen (BCMA)

Also known as TNFRSF17, it is a member of TNF-receptor family, and is called tumor necrosis factor receptor superfamily 17. This receptor is expressed on the surface of B lymphocytes and plasma cells, and is a marker protein of B lymphocyte maturation. Under physiological conditions, BCMA is mainly expressed in plasma mother cells and terminally differentiated plasma cells (PC). Under pathological conditions,BCMA Almost in all MM Tumor cell line (80%–100%) are expressed.The number of BCMA on the surface of malignant PC is much higher than that of conventional PC, which explains why BCMA target has become a battleground for major biological enterprises.

Monoclonal antibody targeting BCMA

SEA-BCMAIt is a new humanized non-fucosylation. IgG1 mAb. The working mechanism of SEA-BCMA may include blocking BCMA activation and its downstream proliferation signal pathway, regulating antibody-dependent cell phagocytosis and enhancing antibody-dependent cytotoxicity.

Its clinical phase I trial (SGNBCMA-001; The preliminary results of NCT03582033) show that it has good safety and combination potential: SEA-BCMA also shows encouraging treatment duration and initial anti-tumor activity in the advanced R/R MM population who have received a lot of treatment before.

Source: blood (2021) 138 (Supplement1): 2740.doi: 10.1182/blood-2021-146047.

Bispecific T Cell cement (BITE)

BiTEs can simultaneously target BCMA on MM tumor cells and CD3ε domain of TCR on T cells. After T cells are combined with myeloma cells, cytotoxic T cells can be activated and secrete cytotoxic factors, thus producing cell killing effect.This part is still in Ⅰ at present./Phase ii.

The following table summarizes the clinical data of bispecific antibodies against BCMA, among which the BiTE bispecific type of BCMA×CD3 is the most common.

Novel trispecific antibody drugs

Researchers are no longer satisfied with treating patients with R/R MM through dual-target therapy.HPN217, an extended half-life (median serum half-life:74 Hours) three specificity. T Cell activation construct (TriTAC)It simultaneously targets BCMA and CD3ε (redirected T cells), and adds serum albumin to prolong the half-life, which can exert cytotoxic effect on myeloma cells.Currently working onR/R MM of 1 /2 Phase I clinical trial for evaluation (NCT04184050). Here are some preclinical data.

Legend: HPN217 mediates the killing effect of autologous T cells of NCG mice on BCMA-dependent/primary MM cells.

Source: blood (2021) 138 (Supplement1): 1185.doi: 10.1182/blood-2021-151880.

CDR101(CDR-lifeCompany’s products)Is simultaneous targeting.CD3、BCMAandPD-L1The trispecific antibody,T cells can be induced into tumor cells expressing BCMA, and the immunosuppressive effect caused by the interaction between PD-L1 and PD-1 can be blocked at the immune synaptic site. Compared with BCMA × CD3 bispecific drugs, CDR101 leads to at least a tenfold increase in T cell-mediated tumor cell lysis, and performs better than the combination of PD-L1 inhibitor and BCMA × CD3 bispecific drugs.CDR101 It may become a new ready-made treatment, providing a more lasting response and a higher cure rate. CDR101 Has excellent drug-like characteristics, high stability and high stability.CHOHigh yield of expression.Based on these findings, new trispecific immunotherapy drugs have high clinical potential and promising clinical application [2].

Antibody drug conjugate (ADC)

After recognizing BCMA on the cell surface, ADC internalizes it into myeloma cells. Through the degradation of lysosomes or endosomes, the payload is released, causing cytotoxicity.

Belantamab mafodotin (GSK2857916)Is targeted by humanization.BCMA IgG1 andMMAF(tubulin polymerization inhibitor). Belantamab mafodotin was approved by the US Food and Drug Administration (FDA) in 2020 to treat patients with R/R MM.This is the first target approved for listing.BCMAimmunotherapy,A multicenter phase II clinical study (NCT03525678) confirmed that the recommended regimen for patients was 2.5 mg/kg, once every three weeks, but the toxicity of the drug was mainly manifested in thrombocytopenia and pericorneal lesions, such as microcystic epithelial changes or superficial punctate keratopathy. In addition to belantamab mafodotin, several other ADCs targeting BCMA, such as AMG 224, MEDI2228 and HDP-101, have also conducted many preclinical or clinical studies at different stages.

Legend: Incidence rate of adverse events caused by Belantamab mafodotin at 2.5 mg/kg and Q3W.

Antibody drug conjugate (ADC) joint test.

In the joint experiment, there are two schemes: belantamab+DEX (dexamethasone) and belantamab+DEX+POM.

belantamab(2.5 mg/kg Q3W) and DEX(20-40 mg Q1W,threeCycle) jointAfter use, the objective remission rate (ORR) was 46%, the complete remission rate (CR) was 14%, the median progression-free survival (PFS) was 4.9 months, and the median overall survival (OS) was 7.4 months. The incidence of AEs from high to low is anemia (83%), keratopathy (82%; Gr3/4: 56%), thrombocytopenia (70%) and so on.

belantamab+DEX+POMUnion ofIn the experimental scheme, the ORR was 88.9%(48/54), and the CR and PR rates were 24.1%(13/54) and 20.4%( 11/54) respectively. However, keratopathy (96.9%) was also the most common AE, and 56.7% of such patients had reached Gr 3/4. These two studies show that POM and DEX may have a positive effect on the curative effect of belantamab. howeverKeratosis is still a challenge in the treatment process.

Legend: Detailed rules and results of belantamab+DEX (Dexamethasone) joint trial scheme.

Source: Blood 2021; 138 (Supplement 1): 1642. doi: https://doi.org/10.1182/blood-2021-149791

CAR-Ttherapy

nowTwo CAR-T therapies based on BCMA have been approved for marketing.And is used for treating patients with multiple myeloma.

Source: "CAR-T therapy targeting BCMA"

7.1

Cilta-cel (Carvykti) for Orense injection.

Sidaki Orense injection(Cilta-cel,Carvykti) yes2022year2moon28Listed in China (NMPAApproved for listing/FDAFormal approval) targeting.BCMAofCAR-TCell products, jointly developed by Janssen and Legendary Bio, Legendary Bio owns 70% interests in Carvykti Greater China and 50% interests overseas.

In CARTITUDE-1 trial, the overall remission rate was 97%, the 18-month progression-free survival rate was 66%, and the 2-year progression-free survival rate was 61%. The 18-month overall survival rate is 81%, and the 2-year overall survival rate is 74%. Compared with similar products, this data is very gratifying. According to the latest news from Kingsley, the sales of the legendary BCMA CAR-T new drug Carvykti in the first half of the year was 24 million US dollars.

7.2

Abecma（Ide-cel）

2021yearthreemoon26Day,FDAapproveBaishimei SquibbAbecma(Ide-cel)be listedAbecma is also a BCMA-oriented CAR-T cell therapy, which is customized from patients’ autologous T cells. Clinical data show that the overall remission rate of all patients is 72%, of which the complete remission rate is 28%; Even for patients who have received various regimens, the remission rate of Abecma still reaches 72%, and this remission is very lasting, and 65% of patients are over 12 months.

Legend: preparation principle of Abecma

7.3

Iqalunsei injection

In addition, June 2, 2022Reindeer biology/Xinda biologyAnnounce BCMA CAR-T therapyIqalunsei injectionThe listing application was obtained.NMPAAccepted, it is expected to become the first domestic independent research and development of the whole process.CAR-Ttherapy. The clinical research data reported at the 63rd ASH annual meeting in 2021 showed that the overall remission rate (ORR) was 94.9%, and the complete remission rate/strict complete remission rate (CR/sCR) was 58.2%, showing the excellent safety and effectiveness of Iqalunsei injection.

Source: NMPA official website

7.4

The clinical trial of CAR-T therapy targeting BCMA is as follows

summary

Judging from the listing situation,Belantamab mafodotin (GSK2857916) is composed of humanized targeting BCMA IgG1 and MMAF (tubulin polymerization inhibitor), which is the first targeted BCMA immunotherapy approved for marketing. At present, there are two CAR-T therapies that have been put on the market, developed by Bristol-Myers Squibb respectively.Abecma(Ide-cel), developed in cooperation with Janssen)/ Legendary Biology.Sidaki Orense injectionFrom the data point of view, the latter effect is better, the ORR is increased from 72% to 97%, and other indicators are relatively better. On June 2nd, 2022, Reindeer Bio/Cinda Bio announced BCMA CAR-T therapy.Application for marketing of Iqalunsei injectionIt has also been accepted by NMPA, and it is expected to become the first CAR-T therapy independently developed in the whole process in China. Let us wait and see! From the therapeutic point of view, CAR-T therapy is at the forefront in terms of clinical data and market situation, but we can’t simply judge the advantages and disadvantages of these products. For example, better anti-BCMA CAR-T cell therapy requires more complicated preparation conditions and more expensive treatment costs, which are unbearable for ordinary families. Therefore, while continuing the existing research, it is necessary to study the potential mechanism affecting the curative effect in order to optimize BCMA targeted immunotherapy.

　 　

Legend: Comparison of clinical efficacy between different immunotherapy products targeting BCMA (see [1] for specific clinical data).

reference data

[1]Targeting BCMA to Treat Multiple Myeloma: Updates From the 2021 ASH Annual Meeting. Front Immunol. 2022 Mar 7; 13:839097. doi: 10.3389/fimmu.2022.839097. PMID: 35320942; PMCID: PMC8936073.

[2] Blood 2021; 138 (Supplement 1): 1583. doi: https://doi.org/10.1182/blood-2021-152160

[3] Blood 2021; 138 (Supplement 1): 1642. doi: https://doi.org/10.1182/blood-2021-149791

* Tweets are used to transfer knowledge. If you have any questions about copyright, please contact BiG Bio-innovation Society within 30 days after the publication of this article.

On December 23rd, Chongqing Jin Kang Sailis announced that it had jointly launched a high-end smart car brand AITO (Chinese name: Aotu), which is a new high-end new energy brand that Huawei has chosen new products and cooperated with car companies. slogan is "A journey of thousands of miles begins with AITO"!

At today’s new product launch conference of Huawei in winter, AITO’s first model, AITO Wenjie M5, was officially launched, with a mid-to-high-end positioning, belonging to an intelligent luxury electric drive SUV (medium-sized), which was built by major teams such as Huawei’s consumer business, including system software, industrial design, engineering technology, ecology, etc., with high autonomy.

In addition, HUAWEI has specially provided Huawei’s household charging piles for new cars, which are genuine Huawei car accessories to help solve the anxiety of users.

The IT House learned that "Huawei only makes parts and does not build cars, but helps enterprises build good cars".

Yu Chengdong said that this model is far superior to other brands in terms of performance, handling and intelligent experience.

Huawei also brought its simple and ultimate industrial design concept to this car. The exterior is luxurious and compact, and the interior is spacious and comfortable, which not only allows everyone to enjoy the convenience of parking and turning around easily in the city, but also allows the main driver and passengers to have a comfortable experience even during the long journey.

With the help of the industrial concept of Huawei team, this car has achieved a simple and extreme design. First, it is equipped with an intelligent cockpit. The AITO M5 can seamlessly flow with other intelligent terminals, completely breaking through the barriers between "people, cars and homes".

In terms of software, the M5 interface of AITO Interface provides advanced sense and intelligent functions, which "surpasses all models and car enterprises", such as L2+intelligent driving assistance, HarmonyOS intelligent split screen, one-button flow, NFC Bluetooth sensorless car key of Huawei watch, 3D face recognition, automatic login to Huawei account, automatic switching of driving information, schedule, real-time updating of car navigation map, intelligent sound source perception in multi-tone area, offline voice assistant, real-time detection of fatigue state by computational vision, etc.

Huawei said that with powerful computing power and operating system, through continuous AI learning optimization and OTA upgrade, HarmonyOS Auto can meet consumers’ demand for intelligent, scene-based and personalized experience upgrade.

IT House understands that AITO Wenjie M5 has six paint colors: ceramic white, pine frost green, ice crystal gray, gold-plated black, mi navy blue and azure blue, and three interior colors: ivory white, extreme night black and agate brown, which can be freely matched.

According to Yu Chengdong, Huawei designed it according to the quality and interior requirements of millions of luxury cars, which exceeded the driving sense of 500-100 million yuan. The interior space was comparable to that of a large SUV, and the cockpit was surrounded in one piece, which perfectly interpreted the experience of "advanced feeling", "simplicity" and "immersion".

In terms of power, AITO Wujie M5 adopts front double wishbone independent suspension (anti-roll), rear multi-link independent suspension (stable), all-aluminum chassis (weight -30%), and is equipped with Huawei’s own DriveOne pure electric drive range-extending platform, which has fast acceleration, long battery life and can be powered by electricity and oil.

It is equipped with 1.5T four-cylinder range extender 3.0, asynchronous AC motor and permanent magnet synchronous motor. The peak power of intelligent four-wheel drive flagship version is 365kW(675N?m), and the performance version of four-wheel drive is 315kW. Its performance is superior, and its endurance exceeds that of Porsche, BMW X3, Mercedes-Benz GLC, Audi Q5L, Tesla Model Y and many other luxury cars, with the highest compression ratio of 15:1, ultra-high thermal efficiency of 41% and 3.

According to Yu Chengdong, this model also has extreme cornering performance, which is stronger than McLaren. In terms of acceleration, it can also achieve acceleration of 4.4 seconds at zero speed and 1.9 seconds at 0-50km/h, and its performance can crush many fuel vehicles and surpass many pure trams.

Advanced precision oil cooling technology is also adopted in AITO Interface M5, which reduces the average peak temperature of winding by 30℃ and the peak temperature of magnetic steel by 15℃.

This model can store 40 kWh of electricity, and has a matching "Huawei Household Charging Pile", which supports fast charging (45 minutes can make the power from 20% to 80%, and 5 hours of slow charging can make the power from 20% to 80%), and of course it can also generate electricity from gasoline (56L fuel tank), and it can also output 3500W(220V) AC power to the outside world. Super fast charging charging charging charging treasure, four-wheel drive flagship version 110.

It is reported that the interior car of AITO’s M5 is a 15.9-inch 2K HDR screen, with 90% screen ratio, 128-color RGB atmosphere lights and seamless panoramic canopy.

In addition, this model also has built-in Huawei Sound’s top luxury audio system and a car audio with a peak of 1200 watts. It is worth mentioning that Huawei also has a high-quality cockpit music experience, providing a 10-million-level music library and a high-quality music area for Huawei music, and supporting the playback of lossless music with 5.1 channels and 7.1 channels.

In other aspects, AITO Wujie M5 comes with its own fragrance system, which claims to have the fastest charging in the car, 66W wired fast charging and 40W wireless fast charging, with five charging interfaces of 1A4C, as well as the advanced crystal diamond handle, the co-pilot’s "Queen’s fill lens", center speaker, 19-unit vocal design, ventilated heating massage seat, Napa leather, HUD head-up display function and so on.

Finally, AITO M5 also provides Huawei Card Owner’s Courtesy Edition, covering the whole life cycle from car purchase to car use, providing preferential installment service and rich owner’s rights and interests. With the owner card of Huawei Card, you can enjoy the owner’s rights and services. In Huawei wallet App, car owners can quickly apply for cards, handle car staging, enjoy cash back and driver accident insurance on the whole line, and create a variety of smart car scenes.

The model is being promoted in Jiaxing, with a maximum discount of 80,000 yuan! The minimum starting price is 179,800 yuan. If you are interested in this model, you can click "Check the car price" in the quotation form to get a higher discount. As a plug-in hybrid vehicle, Tangxin Energy not only has excellent fuel economy and environmental protection performance, but also has excellent driving performance and comfort, so it is a popular choice in the new energy vehicle market. Now is a good time to buy a car. Come to Jiaxing and enjoy the discount of Tang New Energy!

Tang New Energy is a luxury SUV with an atmospheric and steady overall style. Its front face design adopts BYD’s family-style "dragon face" design language, and the air intake grille is decorated with large chrome, which gives people a strong visual impact. The body lines are smooth and concise, and the overall shape is fashionable and dynamic. In addition, Tang New Energy also adopts LED headlight group, which not only improves the lighting effect, but also increases the recognition of vehicles. The side of the car body adopts a smooth waistline, which runs from the front of the car to the rear of the car, increasing the dynamics of the car body. Generally speaking, the design of Tang New Energy not only embodies the sense of luxury, but also does not lose the sense of fashion. It is an excellent SUV model.

As a medium-sized SUV, BYD Tang New Energy has performed well in body size, with a body length of 4870mm, a width of 1950mm, a height of 1725mm and a wheelbase of 2820mm, providing passengers with spacious interior space. The front and rear wheel tracks are 1650mm and 1630mm respectively, which makes the vehicle more stable when driving. In tyre size, the former tyre size is 255/50 R20, and the latter tyre size is also 255/50 R20. This large-size tire not only improves the handling performance of the vehicle, but also makes the vehicle more visually impactful. The side lines of the car are smooth, and the overall shape is fashionable and atmospheric, showing the luxury temperament of BYD Tang New Energy.

The interior design of Tang New Energy Car Series is fashionable and luxurious, and a large number of soft materials and leather wraps are used to improve the texture and comfort of the whole car. The steering wheel is made of leather material, which can be manually adjusted up and down+back and forth, so that the driver can find the most comfortable driving posture. The central control screen size is 15.6 inches, which supports voice recognition control system, including multimedia, navigation, telephone, air conditioning and skylight, and is easy to operate. The front and rear rows are equipped with USB/Type-C interfaces, which are convenient for charging and connecting devices. The front row also has mobile phone wireless charging function, which makes drivers more convenient. The seat is made of imitation leather. The main seat supports front and rear adjustment, backrest adjustment and height adjustment (4 directions), and the auxiliary seat also supports front and rear adjustment and backrest adjustment. The front seats also have heating and ventilation functions to provide a more comfortable driving experience. The rear seats can be tilted in proportion, which increases the practicability of the vehicle. In a word, the interior design of Tang New Energy Car Series is exquisite and rich in configuration, which provides a comfortable and convenient experience for drivers and passengers.

Tang New Energy is equipped with a 1.5T 139 L4 engine with a maximum power of 102 kW and a maximum torque of 231N m.. Equipped with E-CVT continuously variable transmission, it makes the shift smoother and provides a more comfortable driving experience. This engine has excellent power performance and efficient fuel economy, which can meet the needs of daily driving and long-distance travel. Whether it is urban roads or expressways, Tangxin Energy can provide sufficient power support, so that drivers can feel strong power output and stable driving performance.

In terms of the exterior design of Tang New Energy, we can see that the evaluation is very pertinent. The front face adopts a family-style design, the lines are tough, full of strength, the design of the tail penetrating taillights is simple and generous, and the wheels are very beautiful. These details make Tang New Energy present an atmospheric and tough image in appearance, which leaves a deep impression on people. At the same time, as a new energy vehicle, Tangxin Energy also has outstanding performance in environmental protection, energy saving and power. It can be said that Tang New Energy is a car with both value and strength, which is a very good choice for consumers who pursue quality life.

China automobile brands have never given up on the impact on the high-end market. Especially in recent years, with the "Matthew effect" of the automobile market becoming more and more fierce, the leading independent brands have become more and more brave, and they have independently developed and established technical highlands to launch more competitive products in the market.

With the accumulation of sales volume, the market has proved that the high-end models launched by China brand will not lose joint venture models, whether it is Yan value power or configuration quality control. Among them, the most outstanding performance is undoubtedly Han, and the cumulative sales volume in one year has exceeded 100,000 units.

It is worth mentioning that in the past year, there were 1,127 models on sale in China, of which only 43 models sold more than 10,000 yuan a month. Among them, there are only 8 high-end cars with an overall price of more than 200,000 yuan, of which 4 models are C-class cars, which are,, and Han. In the case of chasing after the tigers, Han was able to stand firm in the market segment of medium and large C-class high-end cars, which gradually proved consumers’ recognition of independent high-end models.

Why does Han stand out from the encirclement?

In fact, there are many independent brands that introduce new models to the high-end market every year, and even some car companies spend a lot of money to invite world-class design and management teams, but few independent brands have successfully squeezed into the high-end market, but why did Han succeed?

Everyone who knows it knows that Wang Chuanfu’s ideas and ideas have always been very advanced. When most independent brands earned their heads off for fuel vehicles, they entered the new energy vehicle market more than ten years ago. It is also Wang Chuanfu’s advanced strategic vision that has been leading the rapid development to become the leader of new energy vehicles today.

Twenty years ago, it was impossible for people to imagine that a battery manufacturer had become the only leader in the field of new energy vehicles. As a car company that started with batteries, it is indeed at the forefront of independent car companies in the new energy vehicle market.

With the continuous investment in R&D and innovation, we have mastered the core technologies of the whole industrial chain of new energy vehicles, such as batteries, motors and electronic controls, and are the only car companies in the world with the core technologies of "Three Electricity", which cannot even be achieved. At the same time, in the current global chip shortage, it is also one of the few car companies that are not troubled by the chip shortage, because they can make chips themselves and do not need to rely on foreign imports.

It is also with strong technical strength as a support that its Hanergy has made great efforts in the new energy vehicle market and even begun to seize the market share of fuel vehicles. In July, the total sales volume was 56,975 vehicles, up 89.4% year-on-year and 14.5% quarter-on-quarter, setting a new brand sales record. Among them, the sales of new energy vehicles accounted for 87.85% of the total sales, which further increased compared with June, reaching 50,057 vehicles. As a representative of autonomous medium and large cars, Han also captured the perfect data of 8,522 cars in July, and in June, the cumulative sales volume exceeded 100,000 cars, which was fully recognized by consumers.

At present, the cumulative sales volume in the new energy market has already exceeded 1 million vehicles, making it the only car company in its own brand that has exceeded 1 million vehicles. From this series of sales data, it is not difficult to see that it has successfully changed from a fuel vehicle enterprise to a new energy vehicle enterprise.

Technical strength is the key to breakthrough.

The core technology is the survival of car companies. Knowing this truth, in the past two years, the research and development of new technologies has constantly subverted the outside world’s perception of the industry. From last year’s "blade battery" to this year’s DM-i super hybrid technology, the advent of each new technology has brought subversive effects.

Chairman Wang Chuanfu once said, "Safety is the greatest luxury of electric vehicles". As one of the core components of electric vehicles, the safety of batteries largely determines the safety performance of electric vehicles. The emergence of "blade batteries" has raised the safety of batteries to a new height, and at the same time, it has made Han stand out in the highly competitive automobile market.

As we all know, the traditional power battery produces the battery core in the form of winding, while the "blade battery" adopts the lamination process. Compared with winding structure, laminated structure has more uniform current density, excellent internal heat dissipation performance and is more suitable for high power discharge. This is like a box of the same size, one full of ping-pong balls and the other full of straightedge. We can easily imagine the help of lamination technology to space utilization. Therefore, the blade battery has better cycle characteristics, safety characteristics and energy density.

Among more than 300 safety tests of power batteries, acupuncture test is recognized as the most demanding test, which can be called the "Everest" of battery safety test.

The acupuncture test removes all the outer garments of publicity packaging, so that the true safety of the battery is naked in front of consumers. No one wants an unstable and explosive battery sitting under his ass. Blade battery became famous by acupuncture test in World War I, and its natural safety skill was promoted to a unique position through the acquired technological blessing.

Self-cultivation of flagship models

It has been a year since Han went public. After nearly a year’s investigation, Han did hand over an answer sheet worthy of the flagship model.

However, with the intensification of competition in the automobile market, the range of consumers’ choices has gradually expanded, so while digging deep into demand, they are also constantly striving to meet the consumption upgrade. For example, the newly listed 2021 Han EV standard endurance luxury model, compared with the 2020 Han EV ultra-long endurance luxury model, only reduces the battery capacity, and other configurations have not changed, but the price has dropped by 20,000 yuan, which is enough to be seen, bringing consumers unexpected product value and charm.

From the perspective of positioning and selling price, the direct competitor of Han EV is undoubtedly that the listing of the 2021 standard endurance luxury version of Han EV has not caused much pressure, because the comprehensive strength ratio of Han EV is better.

From the price point of view, the price of the 2021 Han EV standard endurance luxury model after subsidy is only 209,800 yuan, but the comprehensive cruising range can reach 506km；; The starting price after subsidy is 235,900 yuan, which is not only 26,100 yuan higher, but also the comprehensive cruising range is only 468km.

In terms of charging time, even if it is fast charging, it takes 1 hour to wait, while the fast charging time of the 2021 Han EV standard battery life version is only 0.42 hours, which is about 25 minutes. In other words, compared with Han EV, it not only runs farther, but also has a shorter waiting time for charging, which is especially critical for pure electric vehicles. Another point that has to be mentioned is that the safety in China is well known to all, and consumers have their own opinions on who is safer between the two.

Faced with the continuous price reduction, from the new forces of car-making to traditional car companies, most of them avoid their sharp edges and do not confront them head-on, while Han EV chooses positive hard steel, which is undoubtedly supported by strong technical strength.

Write at the end:

As a well-deserved leader of independent new energy vehicles, the road to transformation is not easy. Behind this is decades of technical research, which gives you a proud technical idea and a competitive capital.

The launch of the 2021 Chinese EV standard endurance luxury car further extends the benchmark product advantage of the Chinese EV industry to the market segment of 200,000+mid-to-high-end pure electric cars, and demonstrates the strength and confidence of China New Energy flagship car to continue to lead the market.

　　Xinhua News Agency, Guiyang, January 23rd Title: Old fisherman Wang Chaosheng’s "Landing"

　　Xinhua News Agency reporter Wang Jun, wu si

　　This Spring Festival, Lao Wang is very busy. During this time, a new batch of fry was put into his fish pond, and every detail was careless.

　　Lao Wang’s name is Wang Chaosheng. He is 60 years old. He lives in xiazhai village, Tangtou Town, Sinan County, Guizhou Province. He started fishing in his early 30s and retired to shore at the age of 57. After landing, Wang Chaosheng rented more than 10 mu of land to build pond culture, and raised it for 3 years, which brought good benefits and started a new life.

　　Wujiang River is the largest tributary of the south bank of the upper reaches of the Yangtze River, which flows through 13 of the 28 townships in Sinan County. In order to strictly implement the 10-year ban on fishing in the Yangtze River, the local fishery department has repeatedly gone deep into the two sides of the strait to do ideological work for fishermen. Old fishermen like Wang Chaosheng bid farewell to fishing life in succession. Since 2019, 121 fishermen in Sinan County have been arrested and landed.

　　The fisherman’s understanding card posted on the wall of Wang Chaosheng’s house. Xinhua News Agency reporter Wang Junshe

　　Wang Chaosheng used to fish and earned a considerable income. He has fishing license, crew certificate, fishing boat registration certificate and other procedures. During the slack season, he opened a fishing boat and installed a few nets, and started a "sideline business" in Wujiang.

　　"Growing crops is the main business, but the bulk of family income is still fishing ‘ Sideline ’ 。” Wang Chaosheng said that when he was young, he earned 300,000 to 400,000 yuan in the most year, and earned 10,000 yuan in the most day.

　　Wang Chaosheng is a good fisherman. The wind is high and the waves are urgent. Day and night, he and his wife have been safe for decades. He swam around the river with a width of five or six hundred meters, not to mention. If the amount of wild fish salvaged is not large, it will be robbed at home. If the fishing boat comes home with a full load, he will pull it to towns and counties.

　　Wang Chaosheng misses fishing. However, he also figured it out about retreating to shore. On the one hand, support the ecological protection policy; On the other hand, after landing, family income is relatively stable.

　　"I used to fish, but now I raise fish. I’m still at my old job!" Wang Chaosheng told reporters with a smile. Now, fish farming earns more than 100,000 yuan a year, so Wujiang River can recuperate and the ecological protection of the river basin has been strengthened.

　　Today, Wang Chaosheng feeds forage in the fish pond every morning and evening. Watching the mountain spring flow into the fish pond, the big fish churned up and down, and he was full of energy. Grass carp, catfish and other four or five varieties, the big 14 or 15 Jin, the unit price from 10 yuan to 50 yuan, three fish ponds, there is no shortage of sales.

　　Wang Chaosheng fished in the fish pond. Xinhua News Agency reporter Wang Junshe

　　"Mountain spring water, ecological fish, good quality!" Wang Chaosheng was destined to become attached to fish in this life. At the entrance of the mountain spring flowing into the fish pond, he specially took pebbles and river sand from the river to create a natural living environment for the fish. He planted sweet sorghum and ryegrass with bait to make the fish’s food more original.

　　Because of the good quality of fish, Wang Chaosheng’s fish pond attracted some fishing enthusiasts. There is no charge for fishing, just buy the hooked fish at the actual price. Now, his breeding technology is more refined and his output is increasing year by year.

　　In order to ensure the sustainable benefit of ecological fish farming, technicians from county and township fisheries departments often go to the village to give guidance, feed, change water and prevent diseases. They help Wang Chaosheng to move forward continuously.

　　　"AITO asked the M5 Smart Driving Edition to give me a big surprise. The experience it brought me in terms of intelligence is indeed industry-leading." After the test ride, Zhu Jun Orange, the owner of M7, said so.

　　A few days ago, the first AITO Wenjie M5 series car equipped with Huawei ADS2.0 advanced intelligent driving system and HarmonyOS Intelligent Cockpit 3.0 opened a test ride experience in Yuzhong District, Chongqing, which was also the first appearance of the car in Chongqing. Many consumers went to experience the new driving experience brought by Huawei’s advanced intelligent driving system, and the scene was very popular.

　　A motorcade waiting for consumers to try out. Photo courtesy of the organizer Hualong. com-New Chongqing Client

　　Chongqing is often called "8D Magic City" by netizens because of its complicated roads. He You, the owner of M5EV, mentioned that drivers who can drive in Chongqing can drive all over the country, and the intelligent driving system that can withstand the road test in Chongqing must be relatively mature. Huawei’s advanced intelligent driving system equipped with AITO’s M5 Intelligent Driving Edition has performed well in the trial ride in Chongqing.

　　It is understood that the trial route starts from chongqing heaven and earth, starts along Jiabin Road, passes Huacun Interchange, Jiahua Bridge and Lijiaping Interchange, and finally returns to chongqing heaven and earth. This line is located in the center of Chongqing, and there are endless traffic all day, including tunnels and many viaducts with complicated routes.

　　AITO asking the world M5 intelligent driving edition. Photo courtesy of the organizer Hualong. com-New Chongqing Client

　　During the test ride, Huawei’s advanced intelligent driving system always finds the right driving lane automatically according to navigation and road conditions under safe conditions, and actively seeks opportunities to enter. This broke the past cognition of many consumers on the scene about intelligent driving system, and broke their concerns about intelligent driving extending commuting time. "The intelligent driving system I used to know will always take the initiative to avoid it for safety," He You said. "But it is very flexible and will actively look for opportunities to change lanes and overtake."

　　Zhao Xinglin, the owner of Wujie M5, started the live broadcast when he tried to ride the AITO Wujie M5 version, and shared his driving experience with the riders who could not come to the scene. As an "old driver" who has been driving for nearly 20 years, she highly recognizes the intelligence of this model. In her view, the design of this intelligent driving system is very close to daily life and can respond to various problems encountered by car owners in the driving process in a timely manner. She said: "For example, when we are driving, we often encounter some drivers forcibly cutting in line, and AITO asks the M5 Smart Driving Edition to firmly hold its own lane at this time, while avoiding the safety hazards caused by this situation."

　　Event site. Photo courtesy of the organizer Hualong. com-New Chongqing Client

　　According to the staff, Huawei’s advanced intelligent driving system adopts Huawei’s first intelligent driving interactive game algorithm, which solves the problem that intelligent driving encounters difficult road conditions in complex scenes, and can solve more than 70% of the interactive scene takeover problems, shortening the transit time by 40%, making the driving performance of AITO’s M5 intelligent driving version more like an experienced "old driver".

　　In addition to the flexible "silky" experience, intelligent driving also brings more safety protection to car owners. Zhu Jun Orange, who is engaged in the IT industry, already knows a lot about intelligent driving system, but he was deeply impressed by the safety performance of Huawei’s intelligent driving system. After the test ride, he also had a higher degree of trust in the safety performance of the car’s intelligent driving system. He said: "Its lane change avoidance, acceleration and deceleration are all logical, and it can also simulate the driving habits of real people."

　　According to reports, the fusion sensing system of AITO Zhijie M5 Intelligent Driving Edition is equipped with an overhead lidar, three millimeter-wave radars, 11 high-definition camera groups for lateral and forward visual perception and 12 ultrasonic radars, which can realize the perception of moving and static targets. Its farthest detection distance is about 200 meters, and the horizontal detection angle reaches 120 degrees. In the face of pedestrians or animals suddenly rushing out of the blind area of view, or vehicles parked on the roadside suddenly open the door, it can also realize emergency braking or lane change avoidance, and protect the safety of people and vehicles to the greatest extent. "It protects every owner like a knight," Zhao Xinglin described the safety and reliability of this model.

　　Huawei ADS2.0 advanced intelligent driving system is a blessing for the safety of AITO’s M5 intelligent driving version, which is superimposed with the construction of HarmonyOS’s hot ecology. In addition, HUAWEI DriveONE three-in-one electric drive system helps improve the performance of this model, making it safer, smarter and better. Huawei is bringing new variables to the intelligent driving industry.