Yesterday, the brand-new E300 hybrid car was tested on the road in Stuttgart, Germany. This hybrid version uses a set of 2.0T diesel plus plug-in hybrid power system, which integrates 225kw, 400N·m and matches 9AT. This power system supports the choice of driving mode, and can be driven by a motor alone. However, because the mass of the whole vehicle is as high as 2.1 tons, the battery life is only 51km. This E300 hybrid version can accelerate to 100 kilometers per hour in 5.8s, and only 1.5L when using diesel hybrid mode.

As a luxury brand mid-to high-end car, this hybrid version is optional and adaptive, and the interior is exactly the same as the new car, and the price is only 50,000 euros. However, this hybrid version will be used after it is introduced into China. However, in China, the hybrid version has basically locked in the hybrid mid-to-high-end sedan market, and the 300h hybrid also has a large fan audience, so this E300 hybrid will also face challenges in the domestic market.

　　Zhejiang Online, April 20 (Zhejiang Online reporter, Zhu Geqian, intern, Sui Xue, correspondent, Zhang Ye)Recently, the Junior High School of Hangzhou Wahaha Bilingual School opened an integration course to parents. Sixth graders from each school experienced an experience class on cross-cultural integration of Chinese, English, science, and society and history.

　　Poetic Chinese Classroom – The Cultural Core of Chinese and Western Use

　　How does a Chinese fusion class that cannot see the traces of Western culture achieve cross-cultural integration? The teacher chose four West Lake poems by two writers with deep roots in Hangzhou, Bai Juyi and Su Dongpo, to start group classroom teaching.

　　After getting the materials, the teacher guided each group to complete the corresponding tasks according to the teaching goals – reading through the poems, understanding the poems with pictures, and recommending poems. After deepening their understanding of poems in the first two links, the students went on stage to report the results of the group’s study.

　　Giving the classroom to students and using the more autonomous group collaboration and team display classroom model in the West to learn Chinese classic poetry can be regarded as an innovation in Chinese teaching methods. "In terms of teaching content, we still adhere to the core position of Chinese culture, but in terms of Chinese teaching methods, we continue to try to adopt more student-centered Western teaching strategies," said the teaching teacher.

　　In the future, there will also be comparative reading of Chinese and Western literature and translation and appreciation of Chinese and English classics in the school’s language classes, strengthening comprehensive learning practices, so that students can experience the beauty of language learning in an independent, cooperative and open classroom.

　　Pure English classroom – an all-English immersion environment

　　What is a "story"? Foreign teacher Ciaran led the children to re-understand the "story" from the perspectives of characters, settings and plots in an hour and a half. The all-English class mode made many children a little restrained at first. But the humorous Ciaran teacher soon got to know the students well.

　　Starting from a simple discussion of Who, When and Where, What Happened, these easier-to-understand concepts, students understand the basic concept of "story" and the different forms of "story". By combining life scenes with previous reading experiences, students grasp the three basic elements of story: Character (character), Setting (setting), Plot (plot).

　　Afterwards, Teacher Ciaran prepared the Minions’ story fragment "Competition", using the short film as a material to analyze the different elements that make up the story in a more targeted manner and strengthen the study of theory. Finally, the group’s task list "AT THE MOVIES" was completed in a group collaboration. The students learned and analyzed the structure of the text through four aspects of listening, speaking, reading and writing, and returned to the study of English knowledge.

　　Rigorous Chemistry Classroom: A Comparative Study of Chinese and Western Teaching Concepts and Methods

　　The chemistry classroom fully reflects the rigorous spirit of the subject. The chemistry teacher compared the "Compulsory Education Textbook" (Zhejiang Education Press) and "Science Fusion" (a set of top science courses published by Houghton Mifflin Harcourt Group in the United States, which are used as science textbooks in many public schools in the United States). Combining the advantages of the two sets of textbooks, students are guided step by step to complete the teaching objectives of this class: to understand the physical and chemical properties of acids or bases, and to be able to judge the acid and alkali properties of substances according to the physical and chemical properties of acids or bases.

　　The rigorous classroom was also very interesting, and the students were very interested in the introduction of the teacher in the life situation, and the classroom atmosphere quickly became active. After a class, the students learned not only the chemistry knowledge required by the curriculum standard and the core English vocabulary involved in these knowledge.

　　"What’s even more exciting is that after the science class, some students came over and asked me for pH test strips because they wanted to go back and continue to study the acidity and alkalinity of more substances. This is what we want to train children to better understand the world through their own curiosity and their own perception through science class," said Liu Zhaoyun, a chemistry teacher.

　　Dialectical Society and History Classroom – Seeing the World from Multiple Perspectives

　　Around the two questions of "what is history" and "what are we studying in history", the society and history teacher also replaced the "Yiyan Hall" with the form of "discussion group", and asked each group of students to design a story according to the historical characters assigned. Students work in groups and choose a representative to speak. Other group members judge which plots are real and which are made up.

　　The teacher guides the students to express their opinions with questions and materials, and finds the key to the exit in the collision of viewpoints, which not only gives the students the opportunity to fully express themselves, but also leaves a vast space for thinking. At the same time, the teacher also tries to cooperate with the students to learn. When thinking about the ultimate question that human beings must face, "Where do I come from?", the students are pleasantly surprised to provide many philosophical answers.

　　Learning history is not only about learning about the development and changes of China and the world, but also about cultivating students to understand history philosophically and balance the relationship between themselves and the world. Specific to the junior high school stage, it is the cultivation of historical understanding and critical thinking.

　　In the end, each group was given three passages about Hitler’s teenage, adolescent and middle-aged experiences without his name, and asked to read them and summarize the character’s characteristics. Faced with these historical materials alone, the students felt the character’s loneliness, literature, pity and horror. "To understand and analyze the character from multiple angles rather than to make a coffin with a fixed concept is what we want to pass on to the student through the course. This is true for understanding a person, but even more so for understanding a culture and a concept," the instructor said.

　　If you accidentally miss this integration course experience, parents can also pay attention to participating in this Sunday’s integration course experience, so that your child can experience another cross-cultural journey brought by our school’s math, physics, English and physical education teachers.

　　"Your AI data manager, help you do business together!" Recently, the Ele.me retail merchant SAAS platform "Aoxiang" officially released the "AI business assistant" function for merchants in the retail industry. Through this new business tool, merchants can intelligently generate various business key reports and key data, further enhance business capabilities and seize business opportunities.

　　This business management tool driven by artificial intelligence technology integrates advanced natural language processing, intelligent decision support and deep learning capabilities, which can provide businesses with a full range of business services including weekly report push, index change attribution, competition for business alignment, and market trend selection.

　　AI technology solves business pain points

　　"Hello, I am your AI business assistant, welcome to our platform. I will provide you with weekly report analysis, intelligent interpretation and market opportunity suggestions to make your business decisions more informed." On Monday morning, Mr. Xu, the retailer of Ele.me warehouse store, opened the new version of the Aoxiang APP and found that a new business tool was launched in the upper right corner. After clicking the "View Business Weekly Report" button, the business status of his store in the past week was clear at a glance.

　　The reporter found that the intelligent weekly report generated by the "AI business assistant" not only includes core indicators such as the valid order amount of the store, the number of valid orders, and the estimated gross profit of the store, but also includes intelligent interpretation and overall business suggestions provided by artificial intelligence based on the business operation. For example, through the operation change indicators, the "AI business assistant" will judge which indicators may be abnormal according to the historical data of the merchant. The merchant can see the data fluctuations about the net sales volume of the store, the number of goods on the shelves, the original price of the delivery fee, and the platform bears the delivery fee. Further check the reasons for the fluctuation of the data, and adjust the business strategy accordingly.

　　In addition to its own business diagnosis, the "AI business assistant" can also help merchants further analyze the surrounding business opportunities in the business district where the store is located, as well as the overall market opportunities.

　　According to the introduction, through the "AI operation assistant", merchants can query the corresponding business district according to the specific store, find the surrounding TOP stores, and compare the monthly sales of goods in the shelf rate, out-of-stock return rate, product low price rate, performance timely rate, and manual reply timely rate. These analyses can provide store managers with operational optimization suggestions and the fastest way to grow orders.

　　In addition, the "AI management assistant" can also mine the most promising products in the business circle where the store is located, and provide merchants with product opportunity analysis and product selection suggestions. At the same time, the AI will also provide operators with corresponding sales strategies based on the data.

　　The first batch of application merchants: AI is really fragrant

　　The reporter learned that, as an all-channel service SAAS platform for Ele.me retail merchants, Aoxiang has been the first in the industry to launch AI business tools after researching operators of different sizes, different industries, and different entry times. On the basis of the large model, the "AI business assistant" can disassemble the key data of store operations, and combine natural language to provide merchants with logical and clear data indicators and easy-to-understand business suggestions in a conversational mode.

　　The first batch of merchants to use "AI business assistants" also expressed "AI really fragrant" in the face of convenient new functions.

　　"The weekly report is really practical, and there is no need to summarize the data one by one for the weekly store review." Welcome Supermarket operates dozens of stores, and the person in charge of its operation said that the "AI management assistant" can quickly locate the problem through the index change, directly saving itself the time to locate the store problem. In addition, the indicators of the surrounding competition analysis are also selected accurately, which is the core focus of its daily operation.

　　Beiku Convenience said that although the number of stores it operates is not large, it feels that "weekly reports and data changes are very helpful" after using the AI business assistant, which allows merchants to quickly extract effective indicators from complex indicators and summarize them. The presentation of data and suggestions is also very intuitive.

　　"In the process of daily serving retail merchants, especially small and medium-sized merchants, we feel that merchants have obvious pain points in starting their business, obtaining industry data and analyzing business reports. Now through artificial intelligence data acquisition and analysis, merchants can effectively solve these pain points." Wang Xiaojie, head of Ele.me "AI business assistant", said that this new function is currently open to all Aoxiang merchants. Merchants can use the latest version of the Aoxiang APP. In the future, "AI business assistant" will also be gradually opened to all merchants in the retail industry in the form of tools to help merchants see their own business data.

China Economic News Network (Liu Chenxi)Following the release of Jietu Shanhai new energy sequence to screen the whole network, Jietu Automobile once again detonated its concern. On November 17th, 2023 Guangzhou Auto Show was grandly opened. Jetway Auto made a heavy appearance with all-star lineups such as Jetway Shanhai L9, Jetway Shanhai L6, Jetway Traveler, Jetway Traveler C-DM and Jetway Traveler JMK modified cars, showing Jetway "Travel" in all dimensions.^+”The latest achievement of advanced strategy electrification tells the brand that thank you sir is fully committed to the new energy track.

Run fast, accelerate the sprint of 300,000 annual sales target.

Since its establishment, Jetway has always adhered to "travel"⁺"Strategic initial intention, creating" travel "from 2018 Jietu product sequence.⁺"Market segmentation, by 2023, Jietu Shanhai new energy sequence will open up a brand-new track of" travel+hybrid ",and Jietu Automobile will make great strides in the automobile stock market, creating a new record for the growth rate of China SUV brand with strong growth, and creating an exciting speed for China automobile market.

This year, in the face of the extremely involuted China auto market, Jetway once again ran out of the "Jetway Acceleration". In October, Jetway sold as many as 38,053 vehicles a month, 1-mdash; The cumulative sales volume in October increased by 64.7% year-on-year, making China’s cutting-edge SUV car companies the first in growth rate; Up to now, the cumulative sales volume in 2023 has reached 256,000 vehicles, ranking fifth in China brand fuel SUV market, ranking among the first camp, and successfully winning the trust of 870,000+users and the love of 39 million fans around the world. It is estimated that by the end of 2023, the annual sales volume of Jietu Automobile will exceed 300,000, and the total sales volume in the first five years will exceed 950,000.

Travelers "wild" to help out, achieving new growth in Jietu market

Jetway’s beautiful sales report card is inseparable from the strong help of Jetway travelers. Based on the real needs of users, Jietu Traveler has been created by more than 30 rounds of users. It has four advantages: beauty, joy, city and wildness, which can not only give users the excitement when they move forward, but also provide users with the comfort when they stop. It can not only satisfy users’ pursuit of universal beauty, but also realize the display of self-personality. Its appearance has successfully opened up the market segment of off-road SUV for travel and expanded and upgraded "travel"⁺"Strategy, let Jietu brand more and more" wild ".

Nowadays, cross-country travel has become a new fashion, and the appearance of Jietu travelers positioning "cross-country SUV" is the peak. The new car sold 7931 vehicles in the first month of listing, and the order has reached 43926 vehicles so far; Among them, the proportion of four-wheel drive purchase is as high as 85%, and the proportion of ecological modification is 62%, which fully shows the market popularity and user preference of Jetway travelers, and strongly helps Jetway to sprint through the annual sales target of 300,000 at the end of the year.

C-DM, a Jietu traveler who appeared at this auto show, directly hit the new trend of young people’s electric travel in the new era. The new car adopts Chery Kunpeng super-performance electric hybrid C-DM, equipped with 1.5TD DHE+3DHT165 high-efficiency hybrid power system, with a comprehensive battery life of 1000 km+; With 6.6kW external discharge function, it supports various camping equipment such as ovens and electric cookers. Using Qualcomm Snapdragon 8155 chip, it has the advantages of outstanding face value, powerful power, long comprehensive battery life and first-class safety performance. The new car is expected to go on the market in the first quarter of 2024, which is bound to become a new sales growth point of Jietu Automobile.

Shanhai L9 led the way, "Travel!⁺"Strategy advanced again.

In the face of the fierce wave of new energy, Jietu Automobile accelerated its overall transformation to new energy, and launched Jietu Shanhai new energy product series on the eve of Guangzhou Auto Show, and officially listed its first model — — "Big family, big seven-seat super hybrid SUV" Jetway Shanhai L9, driven by electric hybrid "travel"⁺"Strategy advanced again.

Jietu Shanhai is positioned as a "leader of hybrid cross-country travel", and will launch a strategic layout from five aspects: new sequence, new products, new channels, new ecology and new team to build the world’s first hybrid cross-country brand. Jietu Shanhai relies on Kunlun cross-country platform, Kunpeng super hybrid C-DM technology, lion intelligent cabin/great wisdom driving, extremely changeable space scene ability, "travel"⁺Ecological platform and other five advantages to build the core of product technology, to meet the new travel needs of users who are more convenient, more rational, more immersed and more social.

At the auto show, Jietu Shanhai L9 made its first public appearance after listing. The new car has a long body of 4862mm and a long wheelbase of 2850mm, which is extremely changeable and more in line with the needs of large family users. Using Kunpeng Super Hybrid C-DM, it has an industry-leading thermal efficiency of 44.5%, and the cruising range under comprehensive working conditions reaches 1100Km；; Equipped with Qualcomm 8155 high computing platform, it provides more than 15,000 books on the road, which is convenient for users to plant their own tourist routes at any time. Jietu Shanhai L9 is also the first hybrid model that promises the lifetime warranty of the whole vehicle, and it can be called "the most ideal car with a class of 200,000".

In the next two years, Jietu Shanhai will launch eight new hybrid products, including urban Yueye SUV series, hard-core off-road SUV series and pickup truck series, covering mixed family travel and mixed off-road travel. And innovate the service mode to create exclusive "travel"⁺"The new ecology, it is estimated that 300 mountain and sea experience centers will be officially opened by the end of this year, and the number will increase to 450 by the end of 2024, providing users with 24-hour free charging, free opening of lounges and live broadcast rooms, and 50 km on-site test drive experience services anytime and anywhere.

Facing the future, Jetway will continue to insist on "travel"⁺At the beginning of the strategy, with Jietu Shanhai as the fulcrum, we will create a new business card of "travel+mixing" and create a charged "travel" for users.⁺"Full-scene value experience, driving the brand up and value jump, striding forward towards the goal of becoming a club with an annual sales of one million in 2026, in the" travel "⁺"Run out of the new speed on the road.

　

Click to watch more video highlights of Star Jump > >

Killer took off handstand.

Xing Aowei takes off.

Gao Hu’s Flying Swallow Action

　　Zhejiang Satellite TV’s large-scale charity star diving reality show "China Star Jump", since last week’s transfer to the semi-finals of the master’s tricks, the overall difficulty of the players’ jumping has improved, and the difficulty of the movements has erupted collectively. Especially in Gao Hu and Killer, two "high-platform kings" jumped out of the amazing professional-level movements. Killer took out the difficult movement of 611A handstand and somersaulted forward for half a week in the first jump, and then challenged the highest difficulty 202A of the 10-meter platform since the launch of the diving program, while Gao Hu 302C’s perfect jump of reflexively somersaulted and hugged her knees for one week, which was praised by Olympic champion Li Na, a substitute judge, as "the height that professional athletes can only reach after practicing for one year". This week’s second semi-final is still full of experts, especially Xing Aowei, the Olympic gymnastics champion of cross-border diving, who created a dazzling 720-degree somersault and a 180-degree twist against the sky in the preliminary round. The semi-final will continue to carry forward the spirit of innovation and threatened to "jump the diving action of the next Olympic Games" if he advanced to the final.

　　Killer, Xing Aowei and Gao Hu, who are also non-professional divers, have turned from inexperienced diving novices to almost professional ones. Their respective advantages of "being in harmony with the right time and the right people" are prominent, which is an important weight for their successful breakthrough and the secret behind their successful counterattack.

　　Location: Gao Hu grew up facing the sea, and his childhood "plunge" warmed up and dived.

　　Gao Hu is the "king of the platform" among the contestants. He not only won the 10m platform at the fastest speed in training, but also was the first person in the competition. In addition to the courage and boldness of "being too high to be happy", Gao Hu showed an amazing and perfect swallow in the preliminary round, and the difficulty of the action was also upgraded all the way. Especially in the last semi-final, Gao Hu 302C made a perfect jump by doing a reverse somersault and holding her knees for a week. Even Olympic champion judge Li Na praised this as "the height that professional players can only reach after practicing for one year". He also relied on this difficult and perfect jump to sit firmly on the spot and advance directly to the final without any suspense.

　　The reason why Gao Hu achieved such amazing diving attainments in a short time can be said to be due to the "geographical advantage" occupied since childhood. He is a native of Qingdao, and the urban environment surrounded by the sea on three sides gives Gao Hu a unique advantage before diving. According to Gao Hu himself, "I grew up facing the sea, and I have a deep plot about water. My whole family likes swimming very much, so I have been moving freely in the water since I was three or four years old". According to Gao Hu’s recollection, there are many hills and rocks in his hometown near Qingdao. When he was a child, he was bold. He often avoided his parents’ attention with his friends and jumped from the rocks to the water for excitement. Although the equipment was rudimentary and there was no technical content, his childhood experience was similar to that of today’s diving, especially because he learned Gao Hu’s boldness. It is no wonder that he was able to walk calmly on the 10-meter platform on the first day of training. He once said that "I am not afraid of heights at all and like to challenge the limits." Gao Hu, who has excellent water quality, also revealed that he had passed the diving certificate when he traveled to Palau.

　　In addition, Gao Hu is also a sportsman. He likes to play volleyball since he was a child. He is the leader of the school volleyball team. He has participated in many municipal competitions with the team, and volleyball has also trained Gao Hu’s good arm strength.

　　Timing: Killer was born with good gene dance skills and was born with boldness.

　　Killer has been called "Zhang Dadan" since she entered the competition. In the preliminary competition, she was the first woman on the 10m platform, which was as famous as Gao Hu. In the semi-finals, she was even more powerful, with two consecutive jumps. The first jump of 611A turned upside down for half a week, becoming the first woman to use platform handstand, while the second jump of 202A turned backwards for a week, which was the highest difficulty since the diving program was launched.

　　The reason why Killer dives so well can be said that she won at the starting line because of her favorable weather and natural genes. Killer’s mother is a dance teacher, and her innate motor genes, coupled with the super-high physical flexibility of practicing dance since childhood, give her obvious advantages in diving. In addition, Killer, who is bold by nature, also said that he was particularly love the water and liked swimming since childhood. This boldness surprised everyone when Killer walked into the diving hall for the first time, and immediately won the 10m platform, giving the competitors a modest "duel". In a daily training, the diving hall was suddenly cut off due to an accident, and it was suddenly plunged into darkness. At that time, the staff and players present, especially the girls, screamed with fear and scrambled to climb ashore from the water. At that time, Killer, who was on the shore, jumped into the water and swam in the dark diving hall, exclaiming that "such an opportunity is too rare, swimming in the dark is very exciting", which attracted Gao Hu present to be outdone and jumped into the water.

　　People and Peace: Coach Xing Aowei and the judges all found that small gymnastics and diving are connected.

　　As the Olympic champion of gymnastics, Xing Aowei still can’t hide the champion’s potential in cross-border diving. In addition to his amazing jump in the preliminary round, he let the audience see the high platform handstand for the first time, and even created a dazzling "anti-heaven" action in the second jump: 720-degree somersault and 180-degree turn, which caused a full house of applause. This action is even more created by Xing Aowei. In the semi-finals, he said that he would continue to carry forward the spirit of innovation, and he confidently threatened to "jump the diving action of the next Olympic Games" if he could advance to the final.

　　Xing Aowei has the highest starting line among all the players. As a gymnast of the national gymnastics team and an Olympic gold medal champion, he stood out among all the players from the first day of training. The national diving team and the gymnastics team are veritable neighbors. They used to practice in the same training hall. Therefore, many national diving team members and Xing Aowei have been good friends since childhood, including Li Na, the world diving champion who is the coach in this competition. Therefore, Xing Aowei has no pressure and a sense of formality in the training process. Although gymnastics and diving are two completely different sports, they have a lot in common, especially turning and tumbling, which is why Li Xiaopeng of Prince of gymnastics was specially invited to the jury, and Li Xiaopeng’s position was to comment on diving from a semi-professional perspective. Xing Aowei and Li Xiaopeng are both Olympic champions. Since Li Xiaopeng can be a judge, it can be seen that Xing Aowei’s starting line is high, and their teammates, especially good brothers, let him score in the judges’ scoring.

　　Pay more attention to "China Star Jump" official website: http://www.zjstv.com/splash

　

　　Western Network News (reporter, Liu Wang) Do you dare to take a ride on an online car without the approval of the competent authorities? Recently, a navigation software removed a number of unapproved online car-hailing platforms in Xi’an overnight. Why were these online car-hailing platforms removed? Western Network reporters conducted an investigation.

　　Several ride-hailing platforms were removed from the Autonavi aggregation page

　　Is it difficult to take a taxi during peak hours? Use the Autonavi map to take a taxi. You can call multiple online car-hailing platforms with one click, but in the past two days, many friends who are used to taking a taxi through navigation software have found that the original taxi aggregation page, "Sunshine Travel", "Proper E Line", "Timely Car Use", "An’an Car Use", "Ctrip Car Use", "AA Travel" and other online car-hailing platforms have disappeared. What remains are the four online car-hailing platforms that have obtained the online car-hailing license in Xi’an.

　　Several drivers who had registered on these online ride-hailing platforms told reporters that the online ride-hailing driver port they used issued a notice to them. The notice said that in order to cooperate with the work of Xi’an city regulators, the Xi’an navigation software taxi business was offline from the evening of October 11. Later, the reporter called the Autonavi map taxi line, and the operator told the reporter that the reason why these online ride-hailing cars could not be found was because "there are no cars nearby."

　　Some travel platforms such as "Sunshine Travel" confirmed to the Western Network reporter that on the Autonavi map, the entire Xi’an city does not have its own brand of online car-hailing. The competent authority confirmed to the Western Network reporter that Xi’an has indeed requested the removal of online car-hailing platforms that have not obtained service licenses.

　　Drivers are not happy, passengers complain service can not keep up

　　The way navigation software aggregates illegal online car-hailing platforms has long caused dissatisfaction among some legal online car-hailing drivers in Xi’an. A driver, Master Chen, complained to the Western Network reporter that he spent time participating in the training of online car-hailing drivers and paid a high price to buy vehicles that meet safety standards before obtaining the qualification for quasi-transportation. Drivers of these illegal platforms do not need it. In essence, this is an infringement of illegal operations on legitimate operations.

　　In addition to drivers in the same industry, the "taxi-hailing" aggregation taxi platform has also been dissatisfied by passengers. According to local media reports, Ms. Chu, a resident of Xi’an, had such an experience. "After calling a car, the car experience is not very good. The in-car environment and driver service can’t keep up." Ms. Chu said that she used the Autonavi map ride-hailing function to call a BYD car through an unnamed online ride-hailing platform. The environment and hygiene in the car are not good, and the driver service is not very professional.

　　Map navigation software aggregation network car-hailing platform, who should supervise it?

　　In fact, there are already signs that the navigation software has been removed from the shelves of many online car-hailing entrances in Xi’an. On June 20 this year, Autonavi Map was "discussed" by the management department because the freight of the cruise car was much higher than the freight of the online car-hailing car, and the unauthorized online car-hailing platform was listed on the shelves. The management department asked Autonavi Group to immediately correct the wrong freight information of the cruise car and immediately remove the unauthorized online car-hailing platform. The relevant person in charge of Autonavi Group also promised to remove the unauthorized online car-hailing platform.

　　And people familiar with the matter also revealed that the reason why they "discussed" with Autonavi maps instead of "interviewing" is precisely because the behavior of Autonavi map aggregation network car-hailing is difficult to characterize. In our country, the main responsibility for safe production is borne by enterprises, and the online car-hailing platform is responsible for passengers. Autonavi maps provide the entrance to illegal online car-hailing platforms. In the event of an unsafe accident, does Autonavi map also need to be held responsible? If it needs to be held responsible, is it administrative law enforcement by the surveying and mapping department or the transportation department? On these two issues, there are still legal gaps in local supervision.

　　Reporters found that although the aggregation page of Autonavi maps removed these unapproved online car-hailing platforms, Baidu maps and Ctrip trips can still be searched for online car-hailing platforms such as "Sunshine Travel" and "Ctrip Travel" that have not been approved by the competent authorities.

Industrial trends

　　01 360 released Zhinao 4.0, which has the ability of cross-modal generation.

　　On June 13th, 360 Company held the application conference of 360 Zhinao Big Model, the cognitive general big model "360 Zhinao 4.0" was unveiled, and the 360AI digital man was officially released.

　　In addition, Zhou Hongyi said that the key to overtaking China’s self-developed large model curve in the GPT era is to develop multi-modes. 360 Zhinao has the ability of cross-modal generation, and has the ability of text, image, voice and video processing, which can be applied to scenes such as Wensheng map, Wensheng map and Wensheng video. At the same time, 360AI Digital People Square was released, providing more than 200 roles, including digital celebrities, digital employees and other categories.

　　At the meeting, the multi-modal function of 360 Zhinao "Wensheng Video" was first launched in China, and any text script can generate video, which is not limited by professional skills and materials, showing the ability of "making something out of nothing".

　　Zhou Hongyi said that the core innovation of 360 in the big model lies in AI digital people, and digital people are the future.The most important application entrance of large model. 360 will redefine "digital people" based on the ability of 360 wisdom brain model. Different from traditional digital people who can only output content according to established scripts, 360AI digital people are characterized by having memories, people’s designs and personalities, and being able to reproduce their way of thinking and life experiences.

　　02 can generate video with one click, and Gen2 is open for free trial.

　　Recently, Runway, which is known as the video version of Midjourney and provides technical support for Stable Diffusion and Instant Universe, has developed an AI video editing tool Gen, which has been upgraded from the first generation in February to the second generation, and has been officially released from internal testing.

　　In February of this year, Runway released a model named Gen-1, which can transform an existing video into a new video by applying any style specified by text prompts or reference images.

　　Just over a month later, Runway officially released the more powerful Gen-2 on March 20th, completing the transformation from "editing existing videos" to "Wensheng videos", and providing multiple functions such as text+reference images to generate videos, still pictures to videos, and video style migration. Now, after the internal test in March, Gen2 finally opened a free trial-although the video it generated is only 4 seconds at present, and it has a total usage quota of 105 seconds.

　　In terms of pricing, the standard edition member of Gen2 is 15 dollars/month, the Pro edition member is 35 dollars/month, and the annual membership can get 20% discount.

　　According to reports, Twitter user Steve Mills has experienced its potential ability to generate MV in the Gen-2 beta. This user generated a total of about 500 seconds of video, and finally edited it into a 140-second MV.

　　The author estimates that the whole production will cost at least $30 at the price of the public version. Coupled with the previous study and exploration stage, this price will be higher.

　　Cristóbal Valenzuela, CEO and co-founder of Runway, once said when Gen-1 was released: "We have witnessed the explosion of image generation model, and I firmly believe that 2023 will be a year of video generation model."

　　Chatgpt update, which can generate visual animation with one click.

　　On June 13th, local time, OpenAI announced a major update to its large-scale language model API (including GPT-4 and GPT-3.5-turbo), including adding function calling function and reducing the use cost. After updating, the cost of embedded model is reduced by 75%, and the tokens input length of GPT-3.5-turbo is extended to 16,000.

　　Since the end of March, ChatGPT update announced the launch of plug-in function, the number of third-party plug-ins has increased from 10 to more than 70. With the support of these plug-ins, ChatGPT can not only generate web pages and help users find jobs, but also visualize data directly according to their needs. ……

　　At present, the new version of the model has gradually begun to iterate. The latest versions of gpt-4-0613, gpt-3.5-turbo-0613 and gpt-4-32k-0613 with extended context length all support function calls. Gpt-3.5-turbo-16k does not support function calls, and provides four times the context length, which means that one request can support about 20 pages of text.

　　In addition, the old model began to be gradually abandoned. Applications using the initial version of gpt-3.5-turbo and gpt-4 will be automatically upgraded to the new version on June 27th. Developers who need more time to transition can also manually specify to continue using the old version, but all requests for the old version will be completely abandoned after September 13th.

　　04 Nature refuses to post the generated pictures and videos.

　　On June 13th, local time, Nature magazine announced in an editorial that in order to ensure the integrity, transparency and morality of the research, no pictures, videos or illustrations created by using generative AI tools will be published, unless they are articles related to artificial intelligence.

　　However, Nature does not completely exclude artificial intelligence. The magazine still allows the use of text generated by generative artificial intelligence in articles, as long as it is clearly stated in the method or acknowledgment section. In addition, all sources of data, even data generated with the assistance of artificial intelligence, must be provided by the author. However, Nature firmly refuses to accept any generative artificial intelligence tool as the author of the paper.

···

Frontiers of science and technology

　　01 Meta Releases the First Humanoid Model

　　Meta announced on June 13th local time that it will open some components of a new "humanoid" artificial intelligence model to researchers, which can analyze and complete unfinished images more accurately than existing models.

　　This model is called I-JEPA, which uses the background knowledge of the world to fill in the missing parts of the image, instead of inferring only from nearby pixels like other generative artificial intelligence models. This method adopts the humanoid reasoning method advocated by Yann LeCun, the chief artificial intelligence scientist of Meta Company, which helps to avoid the common mistakes in the image generated by artificial intelligence, such as the problem of having an extra finger.

　　Zuckerberg, CEO of Meta, said that sharing the model developed by Meta with other researchers can help the company promote innovation, find security vulnerabilities and reduce costs. He told investors in April this year: "For us, if the industry standardizes the basic tools we are using, then we can benefit from the improvement of others."

　　02 DeepMind releases new AI system to discover faster algorithms.

　　Researchers at Google DeepMind, an AI research laboratory owned by Alphabet (GOOG), released a new AI system on Wednesday, which can improve the efficiency and sustainability of computing.

　　DeepMind said that this latest breakthrough, published in the scientific journal Nature, focuses on finding faster computer algorithms. The computer algorithm isThe foundation is used by enterprises for trillions of times every day.

　　This AI lab in London is famous for pioneering AI models, such as AlphaFold and mastering complex Go.AlphaGo, which named its new AI system AlphaDev. Based on AlphaZero (iteration of AlphaGo), the system uses reinforcement learning to find faster algorithms for computer science functions such as sorting and hashing. Reinforcement learning is a form of machine learning, in which computers learn and make their own strategies.

　　Colin Murdoch, chief business officer of DeepMind, said, "This means that we can use fewer resources to do the same amount of calculations."

···

Traffic driving

　　01 Huawei won the trademark "Wen Jie" and intended to build a car alone?

　　Trademark electronicsThe system shows that a total of 21 applications for trademark transfer of "Wenjie" have been approved. The transferor is Beijing Yongan Shida Trade Co., Ltd. and Beijing Kechuang Huida Trade Co., Ltd., and the transferee is Huawei Technologies Co., Ltd. The receipt time of the transfer application is March 7 and 8 this year.

　　The specific categories of trademarks involve categories 12, 9, 7, 39, 37, 42, 2, 35, 3, 4, 16, 38, 11, 1, 5, 21, 27 and 41, of which categories 12 and 9 respectively represent automobiles and vehicles, electronic products and scientific instruments.

　　According to the first financial report, Huawei responded that "Huawei does not build cars alone, but builds good cars with car companies" has not changed.

　　In addition, according to the science and technology innovation board Daily, the successful transfer of the trademark "Wen Jie" by Huawei means that Huawei will have the dominant position in the trademark, and it will become the unified brand name of Huawei’s intelligent car selection model in the future.

　　02 The price of the whole department was reduced by 30,000 yuan, and the price of ES8 fell below 500,000 yuan.

　　On June 12th, Auto (hereinafter referred to as "") announced that it would adjust the price of all new cars, and the starting price of all models of the company was reduced by 30,000 yuan.

　　After adjustment, the starting price of ET5 fell below 300,000 yuan to 298,000 yuan; The brand-new ES6 just listed in May this year also dropped to 338,000 yuan, and the price of the brand-new ES8 launched at the end of last year also fell below 500,000 yuan.

　　This adjustment is not limited to the price, and the car rights of Weilai users have also been lowered.

　　Specifically, the rights and interests of the first owner of a new car purchase user are adjusted to a 6-year or 150,000-kilometer warranty for the whole vehicle, of which the three-power system can enjoy a 10-year unlimited mileage warranty; Free power exchange will no longer be used as the basic car rights, users can choose to pay a single fee for power exchange, and then a flexible power supply package will be launched.

　　For the users who have already picked up the car, Weilai promises that the rights and interests of the first car owner will remain unchanged. At the same time, when buying a new car from Weilai, the old users can choose to transfer the car rights of the original car to the new car, or choose to give up their car rights to deduct the car purchase price of 30,000-50,000 yuan. Li Bin, CEO of the company, explained that the old users can choose to give up their rights when buying a new car, which means that they can get 60,000-80,000 yuan cheaper.

The reserved interface of Han series vehicles is in the black shell at the front. The ETC reserved interface can be used for installing driving recorder or ETC equipment. Most people may not know where the reserved interface is. Please share the installation steps and effects of Kailude C1 driving recorder. Just plug in the ETC interface of the original vehicle. This is a two-in-one interface, which does not affect the installation of ETC. Attach a location map.

The installation steps are simple, and the most important thing is to find the reserved interface. Using the crowbar tool, the back shell can be well removed. First, pry the small middle cover from top to bottom and take it down by hand, and then directly take down the pried gaps on the left and right sides of the big shell, so that the reserved interface position can be directly seen.

Kailude C1 driving recorder, the mold corresponding to the vehicle model, and the original one-in-two ETC power plug, crowbar tools, etc.

The model can watch videos on the mobile APP, and the video can also be watched on the big screen of the car. The recorder comes with a wifi mold, and the mobile phone and the car are connected to view without traffic.

foreword

Malignant multiple myeloma(multiple myeloma ； MM) is a kind ofwithMalignant disease characterized by massive proliferation of monoclonal plasma cells in bone marrow. B cell maturation antigen (BCMA) is highly expressed on the surface of MM cells. In the past few years, great progress has been made in various BCMA targeted immunotherapy for recurrent/refractory MM patients, including anti-BCMA monoclonal antibodies, antibody-drug conjugates (ADC), bispecific T cell binders (BITE) and chimeric antigen receptor adoptive T cell therapy (CAR-T). The 63rd annual meeting of American Hematology Society updated some information about the application of BCMA in MM, and based on this annual meeting, the related contents of this paper were sorted out [1].

Immunotherapy targeting BCMA: (1)ADC; 　 (2)CAR-T; 　 (3)BiTE;　

copywriter |　NING

BCell maturation antigen (BCMA)

Also known as TNFRSF17, it is a member of TNF-receptor family, and is called tumor necrosis factor receptor superfamily 17. This receptor is expressed on the surface of B lymphocytes and plasma cells, and is a marker protein of B lymphocyte maturation. Under physiological conditions, BCMA is mainly expressed in plasma mother cells and terminally differentiated plasma cells (PC). Under pathological conditions,BCMA Almost in all MM Tumor cell line (80%–100%) are expressed.The number of BCMA on the surface of malignant PC is much higher than that of conventional PC, which explains why BCMA target has become a battleground for major biological enterprises.

Monoclonal antibody targeting BCMA

SEA-BCMAIt is a new humanized non-fucosylation. IgG1 mAb. The working mechanism of SEA-BCMA may include blocking BCMA activation and its downstream proliferation signal pathway, regulating antibody-dependent cell phagocytosis and enhancing antibody-dependent cytotoxicity.

Its clinical phase I trial (SGNBCMA-001; The preliminary results of NCT03582033) show that it has good safety and combination potential: SEA-BCMA also shows encouraging treatment duration and initial anti-tumor activity in the advanced R/R MM population who have received a lot of treatment before.

Source: blood (2021) 138 (Supplement1): 2740.doi: 10.1182/blood-2021-146047.

Bispecific T Cell cement (BITE)

BiTEs can simultaneously target BCMA on MM tumor cells and CD3ε domain of TCR on T cells. After T cells are combined with myeloma cells, cytotoxic T cells can be activated and secrete cytotoxic factors, thus producing cell killing effect.This part is still in Ⅰ at present./Phase ii.

The following table summarizes the clinical data of bispecific antibodies against BCMA, among which the BiTE bispecific type of BCMA×CD3 is the most common.

Novel trispecific antibody drugs

Researchers are no longer satisfied with treating patients with R/R MM through dual-target therapy.HPN217, an extended half-life (median serum half-life:74 Hours) three specificity. T Cell activation construct (TriTAC)It simultaneously targets BCMA and CD3ε (redirected T cells), and adds serum albumin to prolong the half-life, which can exert cytotoxic effect on myeloma cells.Currently working onR/R MM of 1 /2 Phase I clinical trial for evaluation (NCT04184050). Here are some preclinical data.

Legend: HPN217 mediates the killing effect of autologous T cells of NCG mice on BCMA-dependent/primary MM cells.

Source: blood (2021) 138 (Supplement1): 1185.doi: 10.1182/blood-2021-151880.

CDR101(CDR-lifeCompany’s products)Is simultaneous targeting.CD3、BCMAandPD-L1The trispecific antibody,T cells can be induced into tumor cells expressing BCMA, and the immunosuppressive effect caused by the interaction between PD-L1 and PD-1 can be blocked at the immune synaptic site. Compared with BCMA × CD3 bispecific drugs, CDR101 leads to at least a tenfold increase in T cell-mediated tumor cell lysis, and performs better than the combination of PD-L1 inhibitor and BCMA × CD3 bispecific drugs.CDR101 It may become a new ready-made treatment, providing a more lasting response and a higher cure rate. CDR101 Has excellent drug-like characteristics, high stability and high stability.CHOHigh yield of expression.Based on these findings, new trispecific immunotherapy drugs have high clinical potential and promising clinical application [2].

Antibody drug conjugate (ADC)

After recognizing BCMA on the cell surface, ADC internalizes it into myeloma cells. Through the degradation of lysosomes or endosomes, the payload is released, causing cytotoxicity.

Belantamab mafodotin (GSK2857916)Is targeted by humanization.BCMA IgG1 andMMAF(tubulin polymerization inhibitor). Belantamab mafodotin was approved by the US Food and Drug Administration (FDA) in 2020 to treat patients with R/R MM.This is the first target approved for listing.BCMAimmunotherapy,A multicenter phase II clinical study (NCT03525678) confirmed that the recommended regimen for patients was 2.5 mg/kg, once every three weeks, but the toxicity of the drug was mainly manifested in thrombocytopenia and pericorneal lesions, such as microcystic epithelial changes or superficial punctate keratopathy. In addition to belantamab mafodotin, several other ADCs targeting BCMA, such as AMG 224, MEDI2228 and HDP-101, have also conducted many preclinical or clinical studies at different stages.

Legend: Incidence rate of adverse events caused by Belantamab mafodotin at 2.5 mg/kg and Q3W.

Antibody drug conjugate (ADC) joint test.

In the joint experiment, there are two schemes: belantamab+DEX (dexamethasone) and belantamab+DEX+POM.

belantamab(2.5 mg/kg Q3W) and DEX(20-40 mg Q1W,threeCycle) jointAfter use, the objective remission rate (ORR) was 46%, the complete remission rate (CR) was 14%, the median progression-free survival (PFS) was 4.9 months, and the median overall survival (OS) was 7.4 months. The incidence of AEs from high to low is anemia (83%), keratopathy (82%; Gr3/4: 56%), thrombocytopenia (70%) and so on.

belantamab+DEX+POMUnion ofIn the experimental scheme, the ORR was 88.9%(48/54), and the CR and PR rates were 24.1%(13/54) and 20.4%( 11/54) respectively. However, keratopathy (96.9%) was also the most common AE, and 56.7% of such patients had reached Gr 3/4. These two studies show that POM and DEX may have a positive effect on the curative effect of belantamab. howeverKeratosis is still a challenge in the treatment process.

Legend: Detailed rules and results of belantamab+DEX (Dexamethasone) joint trial scheme.

Source: Blood 2021; 138 (Supplement 1): 1642. doi: https://doi.org/10.1182/blood-2021-149791

CAR-Ttherapy

nowTwo CAR-T therapies based on BCMA have been approved for marketing.And is used for treating patients with multiple myeloma.

Source: "CAR-T therapy targeting BCMA"

7.1

Cilta-cel (Carvykti) for Orense injection.

Sidaki Orense injection(Cilta-cel,Carvykti) yes2022year2moon28Listed in China (NMPAApproved for listing/FDAFormal approval) targeting.BCMAofCAR-TCell products, jointly developed by Janssen and Legendary Bio, Legendary Bio owns 70% interests in Carvykti Greater China and 50% interests overseas.

In CARTITUDE-1 trial, the overall remission rate was 97%, the 18-month progression-free survival rate was 66%, and the 2-year progression-free survival rate was 61%. The 18-month overall survival rate is 81%, and the 2-year overall survival rate is 74%. Compared with similar products, this data is very gratifying. According to the latest news from Kingsley, the sales of the legendary BCMA CAR-T new drug Carvykti in the first half of the year was 24 million US dollars.

7.2

Abecma（Ide-cel）

2021yearthreemoon26Day,FDAapproveBaishimei SquibbAbecma(Ide-cel)be listedAbecma is also a BCMA-oriented CAR-T cell therapy, which is customized from patients’ autologous T cells. Clinical data show that the overall remission rate of all patients is 72%, of which the complete remission rate is 28%; Even for patients who have received various regimens, the remission rate of Abecma still reaches 72%, and this remission is very lasting, and 65% of patients are over 12 months.

Legend: preparation principle of Abecma

7.3

Iqalunsei injection

In addition, June 2, 2022Reindeer biology/Xinda biologyAnnounce BCMA CAR-T therapyIqalunsei injectionThe listing application was obtained.NMPAAccepted, it is expected to become the first domestic independent research and development of the whole process.CAR-Ttherapy. The clinical research data reported at the 63rd ASH annual meeting in 2021 showed that the overall remission rate (ORR) was 94.9%, and the complete remission rate/strict complete remission rate (CR/sCR) was 58.2%, showing the excellent safety and effectiveness of Iqalunsei injection.

Source: NMPA official website

7.4

The clinical trial of CAR-T therapy targeting BCMA is as follows

summary

Judging from the listing situation,Belantamab mafodotin (GSK2857916) is composed of humanized targeting BCMA IgG1 and MMAF (tubulin polymerization inhibitor), which is the first targeted BCMA immunotherapy approved for marketing. At present, there are two CAR-T therapies that have been put on the market, developed by Bristol-Myers Squibb respectively.Abecma(Ide-cel), developed in cooperation with Janssen)/ Legendary Biology.Sidaki Orense injectionFrom the data point of view, the latter effect is better, the ORR is increased from 72% to 97%, and other indicators are relatively better. On June 2nd, 2022, Reindeer Bio/Cinda Bio announced BCMA CAR-T therapy.Application for marketing of Iqalunsei injectionIt has also been accepted by NMPA, and it is expected to become the first CAR-T therapy independently developed in the whole process in China. Let us wait and see! From the therapeutic point of view, CAR-T therapy is at the forefront in terms of clinical data and market situation, but we can’t simply judge the advantages and disadvantages of these products. For example, better anti-BCMA CAR-T cell therapy requires more complicated preparation conditions and more expensive treatment costs, which are unbearable for ordinary families. Therefore, while continuing the existing research, it is necessary to study the potential mechanism affecting the curative effect in order to optimize BCMA targeted immunotherapy.

　 　

Legend: Comparison of clinical efficacy between different immunotherapy products targeting BCMA (see [1] for specific clinical data).

reference data

[1]Targeting BCMA to Treat Multiple Myeloma: Updates From the 2021 ASH Annual Meeting. Front Immunol. 2022 Mar 7; 13:839097. doi: 10.3389/fimmu.2022.839097. PMID: 35320942; PMCID: PMC8936073.

[2] Blood 2021; 138 (Supplement 1): 1583. doi: https://doi.org/10.1182/blood-2021-152160

[3] Blood 2021; 138 (Supplement 1): 1642. doi: https://doi.org/10.1182/blood-2021-149791

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　　How far is it from playing mobile phone every day to illness? Recently, a reporter from qianjiang evening news learned from the hospital that there is a 30-year-old clerk in Hangzhou who deals with computers, keyboards and mice every day, and likes to play with mobile phones during the spare time. As a result, his hands are numb enough to require surgery. Psychologists also warned mobile phone owners that if they keep looking at their mobile phones while shopping, they will spend more money. If you let your mobile phone sleep with you, it will do more harm to your health.

　　Keyboard and mobile phone play too much.

　　In addition to hand numbness, muscle atrophy will occur.

　　Zhou Qi (a pseudonym), 30, keeps her hands on the keyboard at work and keeps brushing her mobile phone at rest. She also has a habit of sleeping on her desk with her hands on her pillow during lunch break. It seems that most people’s living habits have damaged her ulnar nerve. It shows that the right hand is numb and tingling, and it takes a long time to straighten your arm to recover. Even the buttons are awkward, and you can’t even carry chopsticks when eating … … After a series of examinations such as electromyography, Zhou Qi was diagnosed as "cubital tunnel syndrome".

　　The ulnar nerve in medicine is what we usually call "numbness". It is one of the three main meridians on the arm. It starts from the cervical vertebra, passes through the elbow joint, sticks to the inside of the arm and goes down all the way to our ring finger and little finger. It is of great significance to our daily life, and the fine movements of our fingers, such as buttoning, holding chopsticks and holding a pen, can not be achieved without the contribution of ulnar nerve.

　　Frequent elbow flexion and other actions will cause ulnar nerve compression, leading to "cubital tunnel syndrome", which will affect the function of fingers and palms. When the sensory function of ulnar nerve is affected, there will be symptoms of numbness of fingers or palms, and when its motor function is also affected, there will be phenomena such as weakness of fingers or muscles. If it is affected for a long time, it will easily cause muscle atrophy and even cause serious irreversible consequences.

　　Use the keyboard and mouse for a long time, bend your elbows for a long time, or sleep on your desk, etc. Some people have cubital tunnel syndrome due to playing mahjong for several days, and office workers and surgeons are all high-risk groups. In order to completely cure the symptoms, Zhou Qi had to undergo surgery.

　　The doctor reminded that to prevent such diseases, one is: rest.

　　If you repeat an activity, whether it is typing, using the mouse or anything else, it is recommended to take a short break every 10 to 15 minutes to rest your elbow and wrist. During this period, you can stretch and exercise these two parts.

　　Second, keep a good working posture.

　　Adjust the height of the seat to keep the forearm as high as the keyboard. When using the keyboard, there should be no feeling of outward expansion and drooping, so that the elbows and wrists are in a relatively relaxed state.

　　The third is: always be vigilant. Once there is numbness and discomfort in the finger, and it is a constant and persistent feeling, you must not ignore it easily. You should go to the hospital as soon as possible for professional judgment and exclusion.

　　Play mobile phone while walking.

　　Shopping is more expensive.

　　A new study by American scientists shows that if you play with your mobile phone while shopping, it will not only increase the risk of hitting obstacles, but also make people spend a lot of money unconsciously.

　　The research team of Fairfield University asked 231 participants to complete a simulated shopping task. One group of participants restrained themselves from taking out their mobile phones and only paid attention to the goods, while the other group randomly used their mobile phones intermittently for unrelated tasks (such as answering phones, sending and receiving text messages, listening to music, etc.). Both groups of participants used to shop according to a shopping list provided by the researchers, but the results showed that people who used their mobile phones occasionally or constantly in the store made far more unplanned purchases than those who concentrated on shopping.

　　The researchers pointed out that when shopping, people may forget what goods they need most when they are distracted, but they will be attracted by the dazzling array of other goods in the store and take them into their pockets without thinking. Even if you only use your mobile phone occasionally during shopping, it will have this effect, which will lead to additional expenses. Therefore, we should concentrate on saving money when shopping.

　　Wang Yiquan, an expert in early intervention of psychological problems in Hangzhou No.7 Hospital, said: "From the perspective of behavior patterns, those who rely heavily on mobile phones have poor self-control ability, and they are easily influenced by external information such as price reduction and new product listing when shopping, resulting in more impulsive consumption. From the analysis of emotional influence, the information from the mobile phone will affect the mood of shoppers, and these emotions may stimulate impulsive consumption whether positive or negative. Seeing good news, buy something to reward yourself or your family; When you see bad news, you should buy something to comfort yourself and decompress. For example, people often joke that ‘ Bao ’ Treating all diseases is the most vivid explanation of the influence of emotions on shopping. "

　　We have to admit that consumption is indeed a good way to vent and quickly adjust emotions, but only if it is moderate. If it is inappropriate or even unreasonable consumption beyond one’s own ability to pay, one must be alert to whether there are psychological problems.

　　In fact, in life, it is easy to understand the difference between men and women’s shopping habits. For most men, shopping is a kind of "torture". They often think about where to buy something, go straight to the destination and buy it, and then leave. They rarely pay attention to what other stores are selling along the way, and naturally they will not have unplanned consumption. Women tend to take shopping as a kind of "leisure", walk around, shop around, stop and watch more, and the temptation is more likely to lead to many unplanned consumption.

　　Sleeping with your mobile phone is harmful to your eyes.

　　Playing mobile phone for a long time at night often leads to sore eyes, sharp drop in vision, deepening myopia, and even dry eye. Once, because of playing mobile phone games for a long time, the function of meibomian gland was worse than that of the elderly.

　　Everyone’s two eyes have a dominant eye and a non-dominant eye. Under normal circumstances, under the control of the brain, the eyes of both eyes are even, but after lying on the side, one eye has to shoulder a heavier eye task. Over time, if the balance is broken, the vision will be inconsistent between the left and right eyes.

　　Sleeping with mobile phone is harmful to cervical health

　　"Cervical arch inversion" is the most common pathological basis of cervical diseases. High pillow can make the head bend forward and increase the stress of the lower cervical vertebra, which may accelerate the degeneration of cervical vertebra. However, bad living habits such as lying on a high back and watching TV, surfing the Internet for a long time, lying down and playing with a mobile phone, and pulling the cervical vertebra for a long time will also lead to the curve lordosis decreasing, straightening and even bending back.

　　Sleeping with mobile phone affects sleep quality.

　　Adequate sleep is a necessary guarantee for a healthy life. When playing mobile phone, the production of melatonin (secreted by pituitary gland, which directly affects the quality of sleep) will be reduced, which will lead to less sleep and even inability to sleep. I believe those who play mobile phones until midnight or even later have a profound experience — — I’m not sleepy at all. I don’t want to sleep.

　　Sleeping with mobile phones affects family harmony.

　　Young people, once they have cell phone sleepiness, are not in a hurry to find a partner. They think that cell phones are so fun and have everything in them. Why do they need to find a partner? Parents look at the older single children, but they really hate the dead mobile phone. After three days, they cursed, "I know how to play mobile phones every day. Everyone else has grandchildren, so you will give me a mobile phone?"