Industrial trends

　　01 360 released Zhinao 4.0, which has the ability of cross-modal generation.

　　On June 13th, 360 Company held the application conference of 360 Zhinao Big Model, the cognitive general big model "360 Zhinao 4.0" was unveiled, and the 360AI digital man was officially released.

　　In addition, Zhou Hongyi said that the key to overtaking China’s self-developed large model curve in the GPT era is to develop multi-modes. 360 Zhinao has the ability of cross-modal generation, and has the ability of text, image, voice and video processing, which can be applied to scenes such as Wensheng map, Wensheng map and Wensheng video. At the same time, 360AI Digital People Square was released, providing more than 200 roles, including digital celebrities, digital employees and other categories.

　　At the meeting, the multi-modal function of 360 Zhinao "Wensheng Video" was first launched in China, and any text script can generate video, which is not limited by professional skills and materials, showing the ability of "making something out of nothing".

　　Zhou Hongyi said that the core innovation of 360 in the big model lies in AI digital people, and digital people are the future.The most important application entrance of large model. 360 will redefine "digital people" based on the ability of 360 wisdom brain model. Different from traditional digital people who can only output content according to established scripts, 360AI digital people are characterized by having memories, people’s designs and personalities, and being able to reproduce their way of thinking and life experiences.

　　02 can generate video with one click, and Gen2 is open for free trial.

　　Recently, Runway, which is known as the video version of Midjourney and provides technical support for Stable Diffusion and Instant Universe, has developed an AI video editing tool Gen, which has been upgraded from the first generation in February to the second generation, and has been officially released from internal testing.

　　In February of this year, Runway released a model named Gen-1, which can transform an existing video into a new video by applying any style specified by text prompts or reference images.

　　Just over a month later, Runway officially released the more powerful Gen-2 on March 20th, completing the transformation from "editing existing videos" to "Wensheng videos", and providing multiple functions such as text+reference images to generate videos, still pictures to videos, and video style migration. Now, after the internal test in March, Gen2 finally opened a free trial-although the video it generated is only 4 seconds at present, and it has a total usage quota of 105 seconds.

　　In terms of pricing, the standard edition member of Gen2 is 15 dollars/month, the Pro edition member is 35 dollars/month, and the annual membership can get 20% discount.

　　According to reports, Twitter user Steve Mills has experienced its potential ability to generate MV in the Gen-2 beta. This user generated a total of about 500 seconds of video, and finally edited it into a 140-second MV.

　　The author estimates that the whole production will cost at least $30 at the price of the public version. Coupled with the previous study and exploration stage, this price will be higher.

　　Cristóbal Valenzuela, CEO and co-founder of Runway, once said when Gen-1 was released: "We have witnessed the explosion of image generation model, and I firmly believe that 2023 will be a year of video generation model."

　　Chatgpt update, which can generate visual animation with one click.

　　On June 13th, local time, OpenAI announced a major update to its large-scale language model API (including GPT-4 and GPT-3.5-turbo), including adding function calling function and reducing the use cost. After updating, the cost of embedded model is reduced by 75%, and the tokens input length of GPT-3.5-turbo is extended to 16,000.

　　Since the end of March, ChatGPT update announced the launch of plug-in function, the number of third-party plug-ins has increased from 10 to more than 70. With the support of these plug-ins, ChatGPT can not only generate web pages and help users find jobs, but also visualize data directly according to their needs. ……

　　At present, the new version of the model has gradually begun to iterate. The latest versions of gpt-4-0613, gpt-3.5-turbo-0613 and gpt-4-32k-0613 with extended context length all support function calls. Gpt-3.5-turbo-16k does not support function calls, and provides four times the context length, which means that one request can support about 20 pages of text.

　　In addition, the old model began to be gradually abandoned. Applications using the initial version of gpt-3.5-turbo and gpt-4 will be automatically upgraded to the new version on June 27th. Developers who need more time to transition can also manually specify to continue using the old version, but all requests for the old version will be completely abandoned after September 13th.

　　04 Nature refuses to post the generated pictures and videos.

　　On June 13th, local time, Nature magazine announced in an editorial that in order to ensure the integrity, transparency and morality of the research, no pictures, videos or illustrations created by using generative AI tools will be published, unless they are articles related to artificial intelligence.

　　However, Nature does not completely exclude artificial intelligence. The magazine still allows the use of text generated by generative artificial intelligence in articles, as long as it is clearly stated in the method or acknowledgment section. In addition, all sources of data, even data generated with the assistance of artificial intelligence, must be provided by the author. However, Nature firmly refuses to accept any generative artificial intelligence tool as the author of the paper.

···

Frontiers of science and technology

　　01 Meta Releases the First Humanoid Model

　　Meta announced on June 13th local time that it will open some components of a new "humanoid" artificial intelligence model to researchers, which can analyze and complete unfinished images more accurately than existing models.

　　This model is called I-JEPA, which uses the background knowledge of the world to fill in the missing parts of the image, instead of inferring only from nearby pixels like other generative artificial intelligence models. This method adopts the humanoid reasoning method advocated by Yann LeCun, the chief artificial intelligence scientist of Meta Company, which helps to avoid the common mistakes in the image generated by artificial intelligence, such as the problem of having an extra finger.

　　Zuckerberg, CEO of Meta, said that sharing the model developed by Meta with other researchers can help the company promote innovation, find security vulnerabilities and reduce costs. He told investors in April this year: "For us, if the industry standardizes the basic tools we are using, then we can benefit from the improvement of others."

　　02 DeepMind releases new AI system to discover faster algorithms.

　　Researchers at Google DeepMind, an AI research laboratory owned by Alphabet (GOOG), released a new AI system on Wednesday, which can improve the efficiency and sustainability of computing.

　　DeepMind said that this latest breakthrough, published in the scientific journal Nature, focuses on finding faster computer algorithms. The computer algorithm isThe foundation is used by enterprises for trillions of times every day.

　　This AI lab in London is famous for pioneering AI models, such as AlphaFold and mastering complex Go.AlphaGo, which named its new AI system AlphaDev. Based on AlphaZero (iteration of AlphaGo), the system uses reinforcement learning to find faster algorithms for computer science functions such as sorting and hashing. Reinforcement learning is a form of machine learning, in which computers learn and make their own strategies.

　　Colin Murdoch, chief business officer of DeepMind, said, "This means that we can use fewer resources to do the same amount of calculations."

···

Traffic driving

　　01 Huawei won the trademark "Wen Jie" and intended to build a car alone?

　　Trademark electronicsThe system shows that a total of 21 applications for trademark transfer of "Wenjie" have been approved. The transferor is Beijing Yongan Shida Trade Co., Ltd. and Beijing Kechuang Huida Trade Co., Ltd., and the transferee is Huawei Technologies Co., Ltd. The receipt time of the transfer application is March 7 and 8 this year.

　　The specific categories of trademarks involve categories 12, 9, 7, 39, 37, 42, 2, 35, 3, 4, 16, 38, 11, 1, 5, 21, 27 and 41, of which categories 12 and 9 respectively represent automobiles and vehicles, electronic products and scientific instruments.

　　According to the first financial report, Huawei responded that "Huawei does not build cars alone, but builds good cars with car companies" has not changed.

　　In addition, according to the science and technology innovation board Daily, the successful transfer of the trademark "Wen Jie" by Huawei means that Huawei will have the dominant position in the trademark, and it will become the unified brand name of Huawei’s intelligent car selection model in the future.

　　02 The price of the whole department was reduced by 30,000 yuan, and the price of ES8 fell below 500,000 yuan.

　　On June 12th, Auto (hereinafter referred to as "") announced that it would adjust the price of all new cars, and the starting price of all models of the company was reduced by 30,000 yuan.

　　After adjustment, the starting price of ET5 fell below 300,000 yuan to 298,000 yuan; The brand-new ES6 just listed in May this year also dropped to 338,000 yuan, and the price of the brand-new ES8 launched at the end of last year also fell below 500,000 yuan.

　　This adjustment is not limited to the price, and the car rights of Weilai users have also been lowered.

　　Specifically, the rights and interests of the first owner of a new car purchase user are adjusted to a 6-year or 150,000-kilometer warranty for the whole vehicle, of which the three-power system can enjoy a 10-year unlimited mileage warranty; Free power exchange will no longer be used as the basic car rights, users can choose to pay a single fee for power exchange, and then a flexible power supply package will be launched.

　　For the users who have already picked up the car, Weilai promises that the rights and interests of the first car owner will remain unchanged. At the same time, when buying a new car from Weilai, the old users can choose to transfer the car rights of the original car to the new car, or choose to give up their car rights to deduct the car purchase price of 30,000-50,000 yuan. Li Bin, CEO of the company, explained that the old users can choose to give up their rights when buying a new car, which means that they can get 60,000-80,000 yuan cheaper.

The reserved interface of Han series vehicles is in the black shell at the front. The ETC reserved interface can be used for installing driving recorder or ETC equipment. Most people may not know where the reserved interface is. Please share the installation steps and effects of Kailude C1 driving recorder. Just plug in the ETC interface of the original vehicle. This is a two-in-one interface, which does not affect the installation of ETC. Attach a location map.

The installation steps are simple, and the most important thing is to find the reserved interface. Using the crowbar tool, the back shell can be well removed. First, pry the small middle cover from top to bottom and take it down by hand, and then directly take down the pried gaps on the left and right sides of the big shell, so that the reserved interface position can be directly seen.

Kailude C1 driving recorder, the mold corresponding to the vehicle model, and the original one-in-two ETC power plug, crowbar tools, etc.

The model can watch videos on the mobile APP, and the video can also be watched on the big screen of the car. The recorder comes with a wifi mold, and the mobile phone and the car are connected to view without traffic.

foreword

Malignant multiple myeloma(multiple myeloma ； MM) is a kind ofwithMalignant disease characterized by massive proliferation of monoclonal plasma cells in bone marrow. B cell maturation antigen (BCMA) is highly expressed on the surface of MM cells. In the past few years, great progress has been made in various BCMA targeted immunotherapy for recurrent/refractory MM patients, including anti-BCMA monoclonal antibodies, antibody-drug conjugates (ADC), bispecific T cell binders (BITE) and chimeric antigen receptor adoptive T cell therapy (CAR-T). The 63rd annual meeting of American Hematology Society updated some information about the application of BCMA in MM, and based on this annual meeting, the related contents of this paper were sorted out [1].

Immunotherapy targeting BCMA: (1)ADC; 　 (2)CAR-T; 　 (3)BiTE;　

copywriter |　NING

BCell maturation antigen (BCMA)

Also known as TNFRSF17, it is a member of TNF-receptor family, and is called tumor necrosis factor receptor superfamily 17. This receptor is expressed on the surface of B lymphocytes and plasma cells, and is a marker protein of B lymphocyte maturation. Under physiological conditions, BCMA is mainly expressed in plasma mother cells and terminally differentiated plasma cells (PC). Under pathological conditions,BCMA Almost in all MM Tumor cell line (80%–100%) are expressed.The number of BCMA on the surface of malignant PC is much higher than that of conventional PC, which explains why BCMA target has become a battleground for major biological enterprises.

Monoclonal antibody targeting BCMA

SEA-BCMAIt is a new humanized non-fucosylation. IgG1 mAb. The working mechanism of SEA-BCMA may include blocking BCMA activation and its downstream proliferation signal pathway, regulating antibody-dependent cell phagocytosis and enhancing antibody-dependent cytotoxicity.

Its clinical phase I trial (SGNBCMA-001; The preliminary results of NCT03582033) show that it has good safety and combination potential: SEA-BCMA also shows encouraging treatment duration and initial anti-tumor activity in the advanced R/R MM population who have received a lot of treatment before.

Source: blood (2021) 138 (Supplement1): 2740.doi: 10.1182/blood-2021-146047.

Bispecific T Cell cement (BITE)

BiTEs can simultaneously target BCMA on MM tumor cells and CD3ε domain of TCR on T cells. After T cells are combined with myeloma cells, cytotoxic T cells can be activated and secrete cytotoxic factors, thus producing cell killing effect.This part is still in Ⅰ at present./Phase ii.

The following table summarizes the clinical data of bispecific antibodies against BCMA, among which the BiTE bispecific type of BCMA×CD3 is the most common.

Novel trispecific antibody drugs

Researchers are no longer satisfied with treating patients with R/R MM through dual-target therapy.HPN217, an extended half-life (median serum half-life:74 Hours) three specificity. T Cell activation construct (TriTAC)It simultaneously targets BCMA and CD3ε (redirected T cells), and adds serum albumin to prolong the half-life, which can exert cytotoxic effect on myeloma cells.Currently working onR/R MM of 1 /2 Phase I clinical trial for evaluation (NCT04184050). Here are some preclinical data.

Legend: HPN217 mediates the killing effect of autologous T cells of NCG mice on BCMA-dependent/primary MM cells.

Source: blood (2021) 138 (Supplement1): 1185.doi: 10.1182/blood-2021-151880.

CDR101(CDR-lifeCompany’s products)Is simultaneous targeting.CD3、BCMAandPD-L1The trispecific antibody,T cells can be induced into tumor cells expressing BCMA, and the immunosuppressive effect caused by the interaction between PD-L1 and PD-1 can be blocked at the immune synaptic site. Compared with BCMA × CD3 bispecific drugs, CDR101 leads to at least a tenfold increase in T cell-mediated tumor cell lysis, and performs better than the combination of PD-L1 inhibitor and BCMA × CD3 bispecific drugs.CDR101 It may become a new ready-made treatment, providing a more lasting response and a higher cure rate. CDR101 Has excellent drug-like characteristics, high stability and high stability.CHOHigh yield of expression.Based on these findings, new trispecific immunotherapy drugs have high clinical potential and promising clinical application [2].

Antibody drug conjugate (ADC)

After recognizing BCMA on the cell surface, ADC internalizes it into myeloma cells. Through the degradation of lysosomes or endosomes, the payload is released, causing cytotoxicity.

Belantamab mafodotin (GSK2857916)Is targeted by humanization.BCMA IgG1 andMMAF(tubulin polymerization inhibitor). Belantamab mafodotin was approved by the US Food and Drug Administration (FDA) in 2020 to treat patients with R/R MM.This is the first target approved for listing.BCMAimmunotherapy,A multicenter phase II clinical study (NCT03525678) confirmed that the recommended regimen for patients was 2.5 mg/kg, once every three weeks, but the toxicity of the drug was mainly manifested in thrombocytopenia and pericorneal lesions, such as microcystic epithelial changes or superficial punctate keratopathy. In addition to belantamab mafodotin, several other ADCs targeting BCMA, such as AMG 224, MEDI2228 and HDP-101, have also conducted many preclinical or clinical studies at different stages.

Legend: Incidence rate of adverse events caused by Belantamab mafodotin at 2.5 mg/kg and Q3W.

Antibody drug conjugate (ADC) joint test.

In the joint experiment, there are two schemes: belantamab+DEX (dexamethasone) and belantamab+DEX+POM.

belantamab(2.5 mg/kg Q3W) and DEX(20-40 mg Q1W,threeCycle) jointAfter use, the objective remission rate (ORR) was 46%, the complete remission rate (CR) was 14%, the median progression-free survival (PFS) was 4.9 months, and the median overall survival (OS) was 7.4 months. The incidence of AEs from high to low is anemia (83%), keratopathy (82%; Gr3/4: 56%), thrombocytopenia (70%) and so on.

belantamab+DEX+POMUnion ofIn the experimental scheme, the ORR was 88.9%(48/54), and the CR and PR rates were 24.1%(13/54) and 20.4%( 11/54) respectively. However, keratopathy (96.9%) was also the most common AE, and 56.7% of such patients had reached Gr 3/4. These two studies show that POM and DEX may have a positive effect on the curative effect of belantamab. howeverKeratosis is still a challenge in the treatment process.

Legend: Detailed rules and results of belantamab+DEX (Dexamethasone) joint trial scheme.

Source: Blood 2021; 138 (Supplement 1): 1642. doi: https://doi.org/10.1182/blood-2021-149791

CAR-Ttherapy

nowTwo CAR-T therapies based on BCMA have been approved for marketing.And is used for treating patients with multiple myeloma.

Source: "CAR-T therapy targeting BCMA"

7.1

Cilta-cel (Carvykti) for Orense injection.

Sidaki Orense injection(Cilta-cel,Carvykti) yes2022year2moon28Listed in China (NMPAApproved for listing/FDAFormal approval) targeting.BCMAofCAR-TCell products, jointly developed by Janssen and Legendary Bio, Legendary Bio owns 70% interests in Carvykti Greater China and 50% interests overseas.

In CARTITUDE-1 trial, the overall remission rate was 97%, the 18-month progression-free survival rate was 66%, and the 2-year progression-free survival rate was 61%. The 18-month overall survival rate is 81%, and the 2-year overall survival rate is 74%. Compared with similar products, this data is very gratifying. According to the latest news from Kingsley, the sales of the legendary BCMA CAR-T new drug Carvykti in the first half of the year was 24 million US dollars.

7.2

Abecma（Ide-cel）

2021yearthreemoon26Day,FDAapproveBaishimei SquibbAbecma(Ide-cel)be listedAbecma is also a BCMA-oriented CAR-T cell therapy, which is customized from patients’ autologous T cells. Clinical data show that the overall remission rate of all patients is 72%, of which the complete remission rate is 28%; Even for patients who have received various regimens, the remission rate of Abecma still reaches 72%, and this remission is very lasting, and 65% of patients are over 12 months.

Legend: preparation principle of Abecma

7.3

Iqalunsei injection

In addition, June 2, 2022Reindeer biology/Xinda biologyAnnounce BCMA CAR-T therapyIqalunsei injectionThe listing application was obtained.NMPAAccepted, it is expected to become the first domestic independent research and development of the whole process.CAR-Ttherapy. The clinical research data reported at the 63rd ASH annual meeting in 2021 showed that the overall remission rate (ORR) was 94.9%, and the complete remission rate/strict complete remission rate (CR/sCR) was 58.2%, showing the excellent safety and effectiveness of Iqalunsei injection.

Source: NMPA official website

7.4

The clinical trial of CAR-T therapy targeting BCMA is as follows

summary

Judging from the listing situation,Belantamab mafodotin (GSK2857916) is composed of humanized targeting BCMA IgG1 and MMAF (tubulin polymerization inhibitor), which is the first targeted BCMA immunotherapy approved for marketing. At present, there are two CAR-T therapies that have been put on the market, developed by Bristol-Myers Squibb respectively.Abecma(Ide-cel), developed in cooperation with Janssen)/ Legendary Biology.Sidaki Orense injectionFrom the data point of view, the latter effect is better, the ORR is increased from 72% to 97%, and other indicators are relatively better. On June 2nd, 2022, Reindeer Bio/Cinda Bio announced BCMA CAR-T therapy.Application for marketing of Iqalunsei injectionIt has also been accepted by NMPA, and it is expected to become the first CAR-T therapy independently developed in the whole process in China. Let us wait and see! From the therapeutic point of view, CAR-T therapy is at the forefront in terms of clinical data and market situation, but we can’t simply judge the advantages and disadvantages of these products. For example, better anti-BCMA CAR-T cell therapy requires more complicated preparation conditions and more expensive treatment costs, which are unbearable for ordinary families. Therefore, while continuing the existing research, it is necessary to study the potential mechanism affecting the curative effect in order to optimize BCMA targeted immunotherapy.

　 　

Legend: Comparison of clinical efficacy between different immunotherapy products targeting BCMA (see [1] for specific clinical data).

reference data

[1]Targeting BCMA to Treat Multiple Myeloma: Updates From the 2021 ASH Annual Meeting. Front Immunol. 2022 Mar 7; 13:839097. doi: 10.3389/fimmu.2022.839097. PMID: 35320942; PMCID: PMC8936073.

[2] Blood 2021; 138 (Supplement 1): 1583. doi: https://doi.org/10.1182/blood-2021-152160

[3] Blood 2021; 138 (Supplement 1): 1642. doi: https://doi.org/10.1182/blood-2021-149791

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　　How far is it from playing mobile phone every day to illness? Recently, a reporter from qianjiang evening news learned from the hospital that there is a 30-year-old clerk in Hangzhou who deals with computers, keyboards and mice every day, and likes to play with mobile phones during the spare time. As a result, his hands are numb enough to require surgery. Psychologists also warned mobile phone owners that if they keep looking at their mobile phones while shopping, they will spend more money. If you let your mobile phone sleep with you, it will do more harm to your health.

　　Keyboard and mobile phone play too much.

　　In addition to hand numbness, muscle atrophy will occur.

　　Zhou Qi (a pseudonym), 30, keeps her hands on the keyboard at work and keeps brushing her mobile phone at rest. She also has a habit of sleeping on her desk with her hands on her pillow during lunch break. It seems that most people’s living habits have damaged her ulnar nerve. It shows that the right hand is numb and tingling, and it takes a long time to straighten your arm to recover. Even the buttons are awkward, and you can’t even carry chopsticks when eating … … After a series of examinations such as electromyography, Zhou Qi was diagnosed as "cubital tunnel syndrome".

　　The ulnar nerve in medicine is what we usually call "numbness". It is one of the three main meridians on the arm. It starts from the cervical vertebra, passes through the elbow joint, sticks to the inside of the arm and goes down all the way to our ring finger and little finger. It is of great significance to our daily life, and the fine movements of our fingers, such as buttoning, holding chopsticks and holding a pen, can not be achieved without the contribution of ulnar nerve.

　　Frequent elbow flexion and other actions will cause ulnar nerve compression, leading to "cubital tunnel syndrome", which will affect the function of fingers and palms. When the sensory function of ulnar nerve is affected, there will be symptoms of numbness of fingers or palms, and when its motor function is also affected, there will be phenomena such as weakness of fingers or muscles. If it is affected for a long time, it will easily cause muscle atrophy and even cause serious irreversible consequences.

　　Use the keyboard and mouse for a long time, bend your elbows for a long time, or sleep on your desk, etc. Some people have cubital tunnel syndrome due to playing mahjong for several days, and office workers and surgeons are all high-risk groups. In order to completely cure the symptoms, Zhou Qi had to undergo surgery.

　　The doctor reminded that to prevent such diseases, one is: rest.

　　If you repeat an activity, whether it is typing, using the mouse or anything else, it is recommended to take a short break every 10 to 15 minutes to rest your elbow and wrist. During this period, you can stretch and exercise these two parts.

　　Second, keep a good working posture.

　　Adjust the height of the seat to keep the forearm as high as the keyboard. When using the keyboard, there should be no feeling of outward expansion and drooping, so that the elbows and wrists are in a relatively relaxed state.

　　The third is: always be vigilant. Once there is numbness and discomfort in the finger, and it is a constant and persistent feeling, you must not ignore it easily. You should go to the hospital as soon as possible for professional judgment and exclusion.

　　Play mobile phone while walking.

　　Shopping is more expensive.

　　A new study by American scientists shows that if you play with your mobile phone while shopping, it will not only increase the risk of hitting obstacles, but also make people spend a lot of money unconsciously.

　　The research team of Fairfield University asked 231 participants to complete a simulated shopping task. One group of participants restrained themselves from taking out their mobile phones and only paid attention to the goods, while the other group randomly used their mobile phones intermittently for unrelated tasks (such as answering phones, sending and receiving text messages, listening to music, etc.). Both groups of participants used to shop according to a shopping list provided by the researchers, but the results showed that people who used their mobile phones occasionally or constantly in the store made far more unplanned purchases than those who concentrated on shopping.

　　The researchers pointed out that when shopping, people may forget what goods they need most when they are distracted, but they will be attracted by the dazzling array of other goods in the store and take them into their pockets without thinking. Even if you only use your mobile phone occasionally during shopping, it will have this effect, which will lead to additional expenses. Therefore, we should concentrate on saving money when shopping.

　　Wang Yiquan, an expert in early intervention of psychological problems in Hangzhou No.7 Hospital, said: "From the perspective of behavior patterns, those who rely heavily on mobile phones have poor self-control ability, and they are easily influenced by external information such as price reduction and new product listing when shopping, resulting in more impulsive consumption. From the analysis of emotional influence, the information from the mobile phone will affect the mood of shoppers, and these emotions may stimulate impulsive consumption whether positive or negative. Seeing good news, buy something to reward yourself or your family; When you see bad news, you should buy something to comfort yourself and decompress. For example, people often joke that ‘ Bao ’ Treating all diseases is the most vivid explanation of the influence of emotions on shopping. "

　　We have to admit that consumption is indeed a good way to vent and quickly adjust emotions, but only if it is moderate. If it is inappropriate or even unreasonable consumption beyond one’s own ability to pay, one must be alert to whether there are psychological problems.

　　In fact, in life, it is easy to understand the difference between men and women’s shopping habits. For most men, shopping is a kind of "torture". They often think about where to buy something, go straight to the destination and buy it, and then leave. They rarely pay attention to what other stores are selling along the way, and naturally they will not have unplanned consumption. Women tend to take shopping as a kind of "leisure", walk around, shop around, stop and watch more, and the temptation is more likely to lead to many unplanned consumption.

　　Sleeping with your mobile phone is harmful to your eyes.

　　Playing mobile phone for a long time at night often leads to sore eyes, sharp drop in vision, deepening myopia, and even dry eye. Once, because of playing mobile phone games for a long time, the function of meibomian gland was worse than that of the elderly.

　　Everyone’s two eyes have a dominant eye and a non-dominant eye. Under normal circumstances, under the control of the brain, the eyes of both eyes are even, but after lying on the side, one eye has to shoulder a heavier eye task. Over time, if the balance is broken, the vision will be inconsistent between the left and right eyes.

　　Sleeping with mobile phone is harmful to cervical health

　　"Cervical arch inversion" is the most common pathological basis of cervical diseases. High pillow can make the head bend forward and increase the stress of the lower cervical vertebra, which may accelerate the degeneration of cervical vertebra. However, bad living habits such as lying on a high back and watching TV, surfing the Internet for a long time, lying down and playing with a mobile phone, and pulling the cervical vertebra for a long time will also lead to the curve lordosis decreasing, straightening and even bending back.

　　Sleeping with mobile phone affects sleep quality.

　　Adequate sleep is a necessary guarantee for a healthy life. When playing mobile phone, the production of melatonin (secreted by pituitary gland, which directly affects the quality of sleep) will be reduced, which will lead to less sleep and even inability to sleep. I believe those who play mobile phones until midnight or even later have a profound experience — — I’m not sleepy at all. I don’t want to sleep.

　　Sleeping with mobile phones affects family harmony.

　　Young people, once they have cell phone sleepiness, are not in a hurry to find a partner. They think that cell phones are so fun and have everything in them. Why do they need to find a partner? Parents look at the older single children, but they really hate the dead mobile phone. After three days, they cursed, "I know how to play mobile phones every day. Everyone else has grandchildren, so you will give me a mobile phone?"

　　As the world’s first exclusive intelligent body control system for new energy, Yunqi has been receiving much attention since its release in April. Nowadays, the cloud system has been gradually installed on various models of BYD, allowing more users to experience the power of cloud technology. The cloud system was developed by BYD, which made BYD the first enterprise to master the 3-way 6-degree-of-freedom body control technology. BYD’s first product matrix of Yunqi, which currently includes Yunqi -C, Yunqi -A, Yunqi -P and other products, can greatly enhance our driving experience in many aspects such as comfort, handling, safety and off-road.

　　It is luxurious to carry, and Yunnian -C creates a new experience of driving and leaping forward.

　　Yunqi -C intelligent damping body control system can realize rapid and continuous variable adjustment of damping through thousands of signal inputs per second. At the same time, with the cloud algorithm, the optimal damping control scheme can be output in real time to meet the needs of users in different scenarios.

　　During the test drive of Han DM-p Ares Edition, it can be clearly felt that Yunqi -C makes the chassis "hard" by adjusting the damping, which provides greater support for the body and makes the driving and handling feeling of the whole vehicle more stable. At the same time, in the face of bumpy road conditions such as speed bumps and gravel roads, Yunxiao -C can make the chassis "soft", effectively buffering the impact of the road surface on the whole vehicle and greatly improving driving comfort. Whether it is a test of the sense of control or an experience of comfort, Yunqi -C’s performance is amazing.

　　Exercise and comfort are perfectly compatible, and Yunnian -A sets a new benchmark for luxury and comfort.

　　Yunqi -A intelligent air body control system can give consideration to both driving maneuverability and comfort, and at the same time, output precise control strategies through Yunqi Intelligent Computing Center to realize dynamic adjustment of vehicle stiffness, height and damping, and bring more detailed and diversified control to the whole vehicle.

　　In the process of experiencing Tengshi N7 equipped with the standard version of Yunqi -A, the most intuitive feeling is convenience, comfort and luxury. It can realize the functions of welcoming guests and taking things conveniently by adjusting the height, which makes it more convenient for us to get on and off the bus and move things in our daily life. In case of sudden acceleration or sudden braking during driving, the iCCT intelligent comfort control technology carried by Yunqi -A can achieve stronger anti-pitching ability, effectively restrain the vehicle from raising its head and nodding, and greatly reduce the discomfort of the passengers.

　　However, when faced with the scene of high-speed steering such as Panshan Highway, Yunqi -A can not only restrain the roll of the car body, but also integrate suspension, braking and driving through iCVC intelligent vector control technology. Even in the face of the difficult continuous mountain curve, it can easily enter and exit the curve with a very steady posture, and it is handy to control. With the help of iADC intelligent drift control system, drift is no longer the exclusive skill of "high-level players", and even ordinary people can enjoy drift with one click. Yunqi -A has achieved a perfect integration between luxury driving and interesting handling, and the overall experience is impressive.

　　Let cross-country have no threshold, and Yunqi -P brings subversive experience.

　　Yunqi -P intelligent hydraulic body control system integrates three core technologies of machinery, hydraulics and electronic control to fully meet the off-road needs of users. Yunqi -P can adjust the height, damping and stiffness. When driving U8 in mountain road, you can obviously feel that the road vibration is filtered completely, and the support is also in place in the corner. It is not like the traditional hard-core SUV, and there will be no many small vibrations. For Yunnian -P, this kind of comfort experience on unpaved pavement is unprecedented.

　　Looking up at U8 and Equation Leopard 5 under the blessing of Yunnian -P can not only realize the long suspension adjustment stroke, but also have the "hidden function" ultra-high and ultra-low mode. Therefore, even a behemoth like U8 can "hold the bottom" in extreme off-road conditions and "touch the head" in the urban restricted highland basement. At the same time, Yunqi -P with strong off-road performance has also added intelligent genes. The four-wheel linkage function can intelligently distribute the oil pressure through the central control cylinder, so that the four wheels can keep touching the ground at all times, which greatly improves the off-road passability. When parking in the wild, you can also keep the vehicle absolutely level by camping leveling function, so that the rest in the car will no longer be disturbed by terrain. It can be said that Yunqi -P greatly lowered the cross-country threshold, allowing Xiaobai to cross-country easily, bringing unprecedented experience to drivers and passengers.

　　BYD leads the industry with cloud technology.

　　Most importantly, Yunqi started from the systematic control of the vertical direction of the whole vehicle, and realized the safety of the whole vehicle. On the one hand, it can greatly reduce the risk of vehicle rollover and increase the safety of passengers by restraining the change of body posture; On the other hand, the cloud system can adjust the posture of the car body at any time through 3-to-6-degree-of-freedom fusion control under complex road conditions such as snow, mud and water. The cloud chariot system can not only effectively protect the safety of passengers, but also effectively protect the car body, and truly realize the dual protection of people and cars.

　　In the future, BYD will also launch Yunqi -X, which represents the highest level of the global body control system. At the press conference, BYD had already demonstrated the power of Yunqi -X by looking up to U9 for dancing and three-wheeled driving. Recently, Porsche Active Ride, the new hydraulic active suspension system of Porsche’s third generation Paramera, has also earned enough attention in the form of "dancing". Different from Porsche, BYD Yunqi -X is more advanced in system design ideas and realizable functions through innovative new energy architecture. This also proves that BYD has been at the forefront of the industry in the field of body control, and will continue to lead the development direction of the industry with forward-looking technical layout.

　　Through the experience of the whole family of Yunqi, we can clearly feel the overall improvement of the comfort, handling and off-road performance of Yunqi. There is no doubt that Yunqi is a super technology with the ultimate experience and safety. As BYD’s cutting-edge black technology, Yunqi’s birth not only fills the gap in the field of domestic body control technology, but also enables more domestic users to experience the high-end driving and control experience, and further realizes the technological transcendence of established western car companies and promotes the world’s automobile technology to a new height.

The model is being promoted in Jiaxing, with a maximum discount of 80,000 yuan! The minimum starting price is 179,800 yuan. If you are interested in this model, you can click "Check the car price" in the quotation form to get a higher discount. As a plug-in hybrid vehicle, Tangxin Energy not only has excellent fuel economy and environmental protection performance, but also has excellent driving performance and comfort, so it is a popular choice in the new energy vehicle market. Now is a good time to buy a car. Come to Jiaxing and enjoy the discount of Tang New Energy!

Tang New Energy is a luxury SUV with an atmospheric and steady overall style. Its front face design adopts BYD’s family-style "dragon face" design language, and the air intake grille is decorated with large chrome, which gives people a strong visual impact. The body lines are smooth and concise, and the overall shape is fashionable and dynamic. In addition, Tang New Energy also adopts LED headlight group, which not only improves the lighting effect, but also increases the recognition of vehicles. The side of the car body adopts a smooth waistline, which runs from the front of the car to the rear of the car, increasing the dynamics of the car body. Generally speaking, the design of Tang New Energy not only embodies the sense of luxury, but also does not lose the sense of fashion. It is an excellent SUV model.

As a medium-sized SUV, BYD Tang New Energy has performed well in body size, with a body length of 4870mm, a width of 1950mm, a height of 1725mm and a wheelbase of 2820mm, providing passengers with spacious interior space. The front and rear wheel tracks are 1650mm and 1630mm respectively, which makes the vehicle more stable when driving. In tyre size, the former tyre size is 255/50 R20, and the latter tyre size is also 255/50 R20. This large-size tire not only improves the handling performance of the vehicle, but also makes the vehicle more visually impactful. The side lines of the car are smooth, and the overall shape is fashionable and atmospheric, showing the luxury temperament of BYD Tang New Energy.

The interior design of Tang New Energy Car Series is fashionable and luxurious, and a large number of soft materials and leather wraps are used to improve the texture and comfort of the whole car. The steering wheel is made of leather material, which can be manually adjusted up and down+back and forth, so that the driver can find the most comfortable driving posture. The central control screen size is 15.6 inches, which supports voice recognition control system, including multimedia, navigation, telephone, air conditioning and skylight, and is easy to operate. The front and rear rows are equipped with USB/Type-C interfaces, which are convenient for charging and connecting devices. The front row also has mobile phone wireless charging function, which makes drivers more convenient. The seat is made of imitation leather. The main seat supports front and rear adjustment, backrest adjustment and height adjustment (4 directions), and the auxiliary seat also supports front and rear adjustment and backrest adjustment. The front seats also have heating and ventilation functions to provide a more comfortable driving experience. The rear seats can be tilted in proportion, which increases the practicability of the vehicle. In a word, the interior design of Tang New Energy Car Series is exquisite and rich in configuration, which provides a comfortable and convenient experience for drivers and passengers.

Tang New Energy is equipped with a 1.5T 139 L4 engine with a maximum power of 102 kW and a maximum torque of 231N m.. Equipped with E-CVT continuously variable transmission, it makes the shift smoother and provides a more comfortable driving experience. This engine has excellent power performance and efficient fuel economy, which can meet the needs of daily driving and long-distance travel. Whether it is urban roads or expressways, Tangxin Energy can provide sufficient power support, so that drivers can feel strong power output and stable driving performance.

In terms of the exterior design of Tang New Energy, we can see that the evaluation is very pertinent. The front face adopts a family-style design, the lines are tough, full of strength, the design of the tail penetrating taillights is simple and generous, and the wheels are very beautiful. These details make Tang New Energy present an atmospheric and tough image in appearance, which leaves a deep impression on people. At the same time, as a new energy vehicle, Tangxin Energy also has outstanding performance in environmental protection, energy saving and power. It can be said that Tang New Energy is a car with both value and strength, which is a very good choice for consumers who pursue quality life.

On April 15th, the preview of Qin L, a brand-new car of BYD Wang Chaowang, was released. The appearance of the new car continues the "loong" design language, and it will form a two-car pattern with Qin PLUS, with an estimated starting price of more than 120,000 yuan.

In terms of appearance, Qin L’s front face inherits Wang Chaowang’s Longyan aesthetics, and the sharp headlight group is connected by thick chrome trim strips. The word "Qin" is engraved in the center of chrome trim strips, and the interior of the large-size mesh is decorated with breakpoints. The shape surrounded by the front is also very sharp. The waistline of the new car adopts two-stage design, and the roof line is full and smooth. The tail of the new car has a heavy shape, and the classic "Chinese knot" element is added to the taillights. The luminous BYD LOGO is full of science and technology.

In terms of power, the new car will be equipped with a plug-in hybrid system consisting of a 1.5L engine and a motor, in which the maximum power of the engine is 74 kW and the maximum power of the motor is 160 kW. It is equipped with a lithium iron phosphate battery pack, providing 90km and 60km pure electric cruising range.

Answer Comments: According to the application information, the length, width and height of Qin L’s body are 4830/1900/1495mm and the wheelbase is 2790 mm. Except the height of the body is the same as that of Qin PLUS, it is larger than Qin PLUS in other aspects, which is close to the body size of a medium-sized car. The starting price of Qin PLUS on sale is 79,800 yuan, and the price of Qin L will be between Qin PLUS and Han, and 120,000 yuan will be a more suitable point. Judging from the positioning of Qin L, its interior will be more luxurious than Qin PLUS. The specific performance of the new car will not be known until it is officially unveiled.

China automobile brands have never given up on the impact on the high-end market. Especially in recent years, with the "Matthew effect" of the automobile market becoming more and more fierce, the leading independent brands have become more and more brave, and they have independently developed and established technical highlands to launch more competitive products in the market.

With the accumulation of sales volume, the market has proved that the high-end models launched by China brand will not lose joint venture models, whether it is Yan value power or configuration quality control. Among them, the most outstanding performance is undoubtedly Han, and the cumulative sales volume in one year has exceeded 100,000 units.

It is worth mentioning that in the past year, there were 1,127 models on sale in China, of which only 43 models sold more than 10,000 yuan a month. Among them, there are only 8 high-end cars with an overall price of more than 200,000 yuan, of which 4 models are C-class cars, which are,, and Han. In the case of chasing after the tigers, Han was able to stand firm in the market segment of medium and large C-class high-end cars, which gradually proved consumers’ recognition of independent high-end models.

Why does Han stand out from the encirclement?

In fact, there are many independent brands that introduce new models to the high-end market every year, and even some car companies spend a lot of money to invite world-class design and management teams, but few independent brands have successfully squeezed into the high-end market, but why did Han succeed?

Everyone who knows it knows that Wang Chuanfu’s ideas and ideas have always been very advanced. When most independent brands earned their heads off for fuel vehicles, they entered the new energy vehicle market more than ten years ago. It is also Wang Chuanfu’s advanced strategic vision that has been leading the rapid development to become the leader of new energy vehicles today.

Twenty years ago, it was impossible for people to imagine that a battery manufacturer had become the only leader in the field of new energy vehicles. As a car company that started with batteries, it is indeed at the forefront of independent car companies in the new energy vehicle market.

With the continuous investment in R&D and innovation, we have mastered the core technologies of the whole industrial chain of new energy vehicles, such as batteries, motors and electronic controls, and are the only car companies in the world with the core technologies of "Three Electricity", which cannot even be achieved. At the same time, in the current global chip shortage, it is also one of the few car companies that are not troubled by the chip shortage, because they can make chips themselves and do not need to rely on foreign imports.

It is also with strong technical strength as a support that its Hanergy has made great efforts in the new energy vehicle market and even begun to seize the market share of fuel vehicles. In July, the total sales volume was 56,975 vehicles, up 89.4% year-on-year and 14.5% quarter-on-quarter, setting a new brand sales record. Among them, the sales of new energy vehicles accounted for 87.85% of the total sales, which further increased compared with June, reaching 50,057 vehicles. As a representative of autonomous medium and large cars, Han also captured the perfect data of 8,522 cars in July, and in June, the cumulative sales volume exceeded 100,000 cars, which was fully recognized by consumers.

At present, the cumulative sales volume in the new energy market has already exceeded 1 million vehicles, making it the only car company in its own brand that has exceeded 1 million vehicles. From this series of sales data, it is not difficult to see that it has successfully changed from a fuel vehicle enterprise to a new energy vehicle enterprise.

Technical strength is the key to breakthrough.

The core technology is the survival of car companies. Knowing this truth, in the past two years, the research and development of new technologies has constantly subverted the outside world’s perception of the industry. From last year’s "blade battery" to this year’s DM-i super hybrid technology, the advent of each new technology has brought subversive effects.

Chairman Wang Chuanfu once said, "Safety is the greatest luxury of electric vehicles". As one of the core components of electric vehicles, the safety of batteries largely determines the safety performance of electric vehicles. The emergence of "blade batteries" has raised the safety of batteries to a new height, and at the same time, it has made Han stand out in the highly competitive automobile market.

As we all know, the traditional power battery produces the battery core in the form of winding, while the "blade battery" adopts the lamination process. Compared with winding structure, laminated structure has more uniform current density, excellent internal heat dissipation performance and is more suitable for high power discharge. This is like a box of the same size, one full of ping-pong balls and the other full of straightedge. We can easily imagine the help of lamination technology to space utilization. Therefore, the blade battery has better cycle characteristics, safety characteristics and energy density.

Among more than 300 safety tests of power batteries, acupuncture test is recognized as the most demanding test, which can be called the "Everest" of battery safety test.

The acupuncture test removes all the outer garments of publicity packaging, so that the true safety of the battery is naked in front of consumers. No one wants an unstable and explosive battery sitting under his ass. Blade battery became famous by acupuncture test in World War I, and its natural safety skill was promoted to a unique position through the acquired technological blessing.

Self-cultivation of flagship models

It has been a year since Han went public. After nearly a year’s investigation, Han did hand over an answer sheet worthy of the flagship model.

However, with the intensification of competition in the automobile market, the range of consumers’ choices has gradually expanded, so while digging deep into demand, they are also constantly striving to meet the consumption upgrade. For example, the newly listed 2021 Han EV standard endurance luxury model, compared with the 2020 Han EV ultra-long endurance luxury model, only reduces the battery capacity, and other configurations have not changed, but the price has dropped by 20,000 yuan, which is enough to be seen, bringing consumers unexpected product value and charm.

From the perspective of positioning and selling price, the direct competitor of Han EV is undoubtedly that the listing of the 2021 standard endurance luxury version of Han EV has not caused much pressure, because the comprehensive strength ratio of Han EV is better.

From the price point of view, the price of the 2021 Han EV standard endurance luxury model after subsidy is only 209,800 yuan, but the comprehensive cruising range can reach 506km；; The starting price after subsidy is 235,900 yuan, which is not only 26,100 yuan higher, but also the comprehensive cruising range is only 468km.

In terms of charging time, even if it is fast charging, it takes 1 hour to wait, while the fast charging time of the 2021 Han EV standard battery life version is only 0.42 hours, which is about 25 minutes. In other words, compared with Han EV, it not only runs farther, but also has a shorter waiting time for charging, which is especially critical for pure electric vehicles. Another point that has to be mentioned is that the safety in China is well known to all, and consumers have their own opinions on who is safer between the two.

Faced with the continuous price reduction, from the new forces of car-making to traditional car companies, most of them avoid their sharp edges and do not confront them head-on, while Han EV chooses positive hard steel, which is undoubtedly supported by strong technical strength.

Write at the end:

As a well-deserved leader of independent new energy vehicles, the road to transformation is not easy. Behind this is decades of technical research, which gives you a proud technical idea and a competitive capital.

The launch of the 2021 Chinese EV standard endurance luxury car further extends the benchmark product advantage of the Chinese EV industry to the market segment of 200,000+mid-to-high-end pure electric cars, and demonstrates the strength and confidence of China New Energy flagship car to continue to lead the market.

　　Huawei usually releases new P-series machines in the spring, and it’s the P70 series this year. According to mobile phone China, Huawei P70 series has a lot of news on the Internet, but not much about the price. Some digital bloggers recently broke the news that the price of Huawei P70 series may be similar to that of Mate60 series.

　　Huawei P70 series imaginary map

　　Recently, a blogger wrote that what is the price of Huawei P70 series? Refer to the Mate60 series, which is not bad. In the comment area, some netizens suspected of pollen said that the P70 series would be cheaper than the Mate60 series, while bloggers replied that it was "not much cheaper", which seemed to confirm the speculation that the P70 series was relatively cheaper. In addition, some netizens asked whether Huawei P70 series will continue the color scheme of Rococo White, while bloggers said that P70 series has white, but it is not necessarily Rococo White.

　　Let’s review the price of Huawei Mate60 series:

　　Huawei Mate 60-12 GB+256 GB 5499 yuan; 12gb+512gb5,999 yuan; 12GB+1TB 6999 yuan

　　Huawei Mate 60 Pro-12 GB+256 GB 6499 yuan; 12GB+512GB 6999 yuan; 12GB+1TB 7999 yuan

　　Huawei Mate 60 Pro+-16GB+512GB 8999 yuan; 16GB+1TB 9999 yuan

　　Huawei Mate 60 RS extraordinary master-16GB+512GB 11999 yuan; 16GB+1TB 12999 yuan

　　According to the blogger’s news, the starting price of Huawei P70 series should be less than 5499 yuan. In addition, the starting price of Huawei P60 series is 4488 yuan, so the starting price of P70 series can be expected.

With the approaching of the listing date of M9, more and more information is exposed. Recently, a person close to the supply chain revealed that the innovative composite current collector of lithium battery is expected to be applied in the M9.

The composite current collector is a sandwich structure of "metal -PET/PP polymer material-metal", which replaces the original pure metal foil. It has the application advantages of high safety, long life, high energy density and low raw material cost, and is expected to replace the traditional current collector and become the mainstream material of lithium battery current collector in the future.

Guangzhou Automobile Ai ‘an released magazine battery 2.0, which is the first battery in China to announce the adoption of composite current collector. The first model is Haoplatinum GT. At the launch conference of the car, Ai ‘an also announced the test report of the bullet shooting fully charged battery pack. The results showed that the bullet penetrated three batteries, which caused the battery pack to be short-circuited and burst in an instant, but the battery pack just smoked and did not catch fire, and the temperature dropped to room temperature after standing for 24 hours.

In addition, Contemporary Amperex Technology Co., Limited Kirin battery has adopted a composite current collector, which is mounted on pure electric MPV Krypton 009.

According to the research report of CITIC Jiantou, the composite current collector is both safe and economical, which is a major innovation in lithium batteries. In 2023, the industrial trend has gradually become clear and accelerated significantly, and equipment manufacturers, new copper foil factories, battery factories and end users have accelerated their layout; At the same time, the technology continues to break through, promoting the composite current collector to mass production, and 2023 is expected to become the first year of mass production.