Peng Yuyan’s firstThe stills were exposed at the Berlin International Film Festival

1905 movie network news Peng Yuyan’s first "Incense of the First Furnace" stills were exposed at the Berlin International Film Festival. He was seen wearing a white sleeveless jumpsuit, showing off the perfect arm muscles and uninhibited expression. In the film, Peng Yuyan will challenge the playboy Qiao Qiqiao to stage a love-hate relationship with Ge Weilong played by Ma Sichun.

"First Incense" boot photo

The movie "First Incense" is based on Zhang Ailing’s novella "Agarwood Crumbs · First Incense". It tells the story of Ge Weilong, a female student from Shanghai, who goes to study in Hong Kong and lives in the home of his aunt, Mrs. Liang, but is trained by Mrs. Liang as a social bait. Finally, Ge Weilong marries his son-in-law brother, Qiao Qiqiao, and becomes a tool for making money. The film is directed by Xu Anhua, and this is her third time shooting Zhang Ailing’s novel after and after.

Yin Fang’s "First Incense" finishing photo

It is reported that "The First Incense" also brings together actors such as Yu Feihong, Zhang Junjun, Fan Wei, Liang Luoshi, Zhang Jianing, Yin Fang, Qin Pei, and Bai Bing, and the film will be released in China in 2020.

In January, some netizens discovered that former well-known actor Edison Chen traveled to Japan and stayed there for a while.

Unexpectedly, Edison Chen’s trip to Japan could also cause trouble. Sure enough, he was a very outstanding man. No matter where he went, he was the focus of everyone’s attention.

Some netizens have exposed on the Internet that Edison Chen once beat up passers-by in a shopping mall during his stay in Japan, simply because the other party called him by the wrong name.

The husband who was beaten by passers-by later came out to speak out, angrily denouncing Chen Edison’s beating behavior, and claiming that they didn’t want to disturb the star’s life, but they still accidentally disturbed the other party.

However, if you are disturbed, you can’t beat people because of this.

The husband of the party revealed that his wife just called Edison Chen Eason Chan, so she was beaten up.

It was a bit of a surprise.

According to the data, Edison Chen’s English name is Edison, while Eason Chan’s English name is Eason. The pronunciation of the two is indeed a bit similar.

Even when He Jiong was doing a show with Edison Chen, he once called Edison Chen’s English name incorrectly, leaving Edison Chen speechless.

In response, Chen Edison’s reaction was that he was not very happy and did not hit anyone on the show.

It had to be said that under normal circumstances, Edison Chen was still unlikely to hit someone. After all, as a civilized person, a gentleman would not make a move.

Hitting people for no reason is not Chen Edison’s style.

Therefore, regarding the exposure of this netizens, we must also eat melons rationally. If we listen to both, we will be bright, but if we believe it, we will be dark. We must not listen too much to his side of the story.

It is reported that when Edison Chen was on the streets of Canada and found that he was followed by netizens, he only angrily scolded the other party and asked them not to follow the photo.

He didn’t hit anyone.

It can be seen that Edison Chen did not have a tendency to violence back then, let alone beat people up because of this kind of thing.

According to the data, Edison Chen was born in Canada in 1980 and received foreign education from an early age. Later, he followed his family to visit Hong Kong and was discovered by talent scouts in the entertainment industry.

With his handsome appearance and superb acting skills, Edison Chan has achieved great success in Hong Kong, winning not only the love of many fans, but also a lot of love.

Unfortunately, when Edison Chen was at his peak, he was forced to quit the entertainment industry due to an accidental leak, which caused his career to plummet.

This incident affected many artists in the Hong Kong entertainment industry at that time, and many people nearly lost their career prospects as a result.

Forced into despair, Chen Edison returned to live in Canada and soon married Qin Shupei, the ex-wife of Huayi Brothers boss Zhao Lei.

After getting married, Chen Edison turned into a three-good man and has been accompanying his wife. He lived a very happy life and showed his love from time to time.

Change his romantic and suave image.

However, in 2023, Chen Edison seemed to be a little dishonest again. After traveling to Japan, he took photos with local female fans and behaved rather intimately.

It reminds people of a very classic old saying: "The country is easy to change and the nature is hard to change".

Perhaps, only Edison Chen himself knows whether he is an easy-to-change nature or a prodigal son who will never change his head!

It can only be said that Edison Chen is a legendary figure. When he debuted in the entertainment industry, he became popular all over the Internet. Even after he retired from the industry, his limelight remained the same.

His popularity was even higher than that of many A-list celebrities, which made people give him a thumbs up.

How do you feel about Edison Chen’s situation?

Responsible editor:

　　◎ Science and Technology Daily reporter, Liu Yuanyuan

　　During this time, an artificial intelligence chat system called ChatGPT was like a spring thunder on the ground, suddenly exploding the network.

　　"Judging from the current general conversation experience, the biggest highlight of ChatGPT is its excellent intention recognition and language understanding ability, which makes people realize that the interaction ability of artificial intelligence has achieved leapfrog progress."Analysys wisdom institute senior analyst Chen Chen evaluation.

　　This magical human-computer interaction experience has aroused people’s enthusiasm for racking their brains to ask questions to ChatGPT, and brought it an amazing number of users: the system was launched by the American artificial intelligence research company OpenAI more than two months ago, and it has reached 100 million monthly active users in January this year. The user growth rate is unprecedented.

　　This product is very popular, and its important behind-the-scenes contributor is the technology known as the pre-trained model in the industry. In the face of the explosion of ChatGPT, domestic technology institutions and enterprises have "shined their swords".According to the latest news, the Chinese version of ChatGPT will be available to the public next month.

　　ChatGPT answers questions about itself.

　　The scale of parameters skyrockets from millions to hundreds of billions

　　"At present, pre-training technology is an important breakthrough in artificial intelligence research," explained Su Zhong, head of the Future Technology Center of Ali Research Institute.In traditional research methods, the cost of labeling has been an obstacle preventing artificial intelligence algorithms from pushing towards larger data sets, while pre-training techniques can train a large-scale deep learning model without relying on data annotations.

　　The Science and Technology Daily reporter learned that because data annotation is not required, pre-trained models can often use larger datasets, so they can choose larger model sizes – which has given rise to pre-trained large models.

　　"Compared with the previous artificial neural networks, the biggest difference of the pre-trained large model is that it is large enough, and the deep learning network has many layers, many connections, and many parameters." Zhang Jiaxing, a lecturer at the Cognitive Computing and Natural Language Research Center of IDEA Research Institute (Guangdong-Hong Kong-Macao Greater Bay Area Digital Economy Research Institute), introduced in an interview with reporters that the deep learning network around 2012 has only a few million parameters; the mainstream pre-trained model around 2018 reached 100 million parameters; the large-scale pre-trained model that has been proved to be very effective has hundreds of billions of parameters, which have been improved thousands of times in just a few years.

　　ChatGPT answers questions about itself.

　　Quantitative change leads to qualitative change. Su Zhong analyzed that in the evaluation of various techniques of the pre-trained model, the performance of the algorithm showed a rule:The larger the data size and the more parameters of the pre-trained model, the higher the output accuracy of the algorithm.

　　In addition to the large scale, Zhang Jiaxing said that the current pre-trained large model is very suitable for parallel training due to the use of new structural models. At the same time, in terms of training methods, the pre-training tasks of artificial neural networks are similar to "problem solving", such as removing a word or the first half of a sentence and letting the pre-trained model use massive big data to recover the sentence. In this way, the pre-trained model’s "problem solving" ability will get better and better. Moreover, on the basis of large language models, the introduction of instruction learning can far exceed the benefits of model fine-tuning. On this basis, human feedback can help the model better understand human intentions and receive information, and the human-machine dialogue will become more and more smooth.

　　ChatGPT answers questions about itself.

　　"ChatGPT can be said to be a landmark artificial intelligence product in terms of underlying data, core technology, user experience, etc." Zhang Xiangyu, head of basic research at Megvii Research Institute, said,The core technology of ChatGPT is the artificial intelligence language model, the key is how to make the artificial intelligence model have logical reasoning ability, and how to make artificial intelligence learn the knowledge of the whole Internet.These ChatGPTs are basically achieved, thus making great breakthroughs in decision-making and knowledge.

　　Many domestic science and technology institutions have established a presence in related fields

　　According to foreign media reports, a number of foreign tech giants are investing heavily in pre-training models and artificial intelligence generated content (AIGC) track. The reporter learned that many domestic science and technology institutions and enterprises have laid out related fields.

　　Zhang Jiaxing told reporters that the IDEA Research Institute’s Cognitive Computing and Natural Language Research Center has been in this direction for a long time, and the center has the largest open-source model system in China – the list of gods. The 98 models that have been open-sourced are fully supporting the development of China’s AIGC, exploring the development of personalized and customizable models adapted to various fields, and supporting all natural language processing (NLP) tasks.

　　"It’s great to see the emergence of AIGC and ChatGPT in the tenth year of the rapid development of deep learning. Today, all these natural language processing tasks are being unified into the ChatGPT model. We are also integrating previous models and technologies to launch our ChatGPT-like model." Zhang Jiaxing said.

　　Source: Visual China

　　The reporter learned from Baidu that Baidu has invested in the development of related technologies similar to ChatGPT. The name of the project is determined to be ERNIE Bot. The English name is ERNIE Bot. It will be open to the public after the closed beta is completed in March. At present, ERNIE Bot is sprinting before going online.

　　"ChatGPT mainly involves natural language processing related technologies, which is one of the applications in the field of cognitive intelligence. iFLYTEK has a long-term and profound accumulation of technologies and applications in this direction." On the evening of February 8, iFLYTEK responded on the investor interaction platform that the company has open sourced a series of Chinese pre-trained language models in 6 categories and more than 40 general fields for the field of cognitive intelligence, and launched a generative pre-trained large model task in December last year. Artificial intelligence learning machine will become the first product to land this technology, and will be released at the product level in May this year.

　　In addition, 360 said on its investor interaction platform on February 7 that the company also plans to launch a prototype version of ChatGPT-like technology as soon as possible. "AIGC technology can assist in the improvement of digital security capabilities in addition to its application in search engines," 360 said.

　　(Science and Technology Daily reporters Cao Xiuying and Liu Yan also contributed to this article.)

　　Source: Science and Technology Daily, the pictures in the text are provided by the author unless indicated

　　Editor: Shen Wei (Internship)

　　Review: Yue Liang

　　Final Review: Wang Tingting

　　On August 14, the Civil Aviation Administration issued a notice reiterating the relevant regulations on passengers carrying power banks on flights:

　　It is strictly forbidden to carry power banks in checked baggage.

　　It is strictly forbidden to carry power banks with a rated energy of more than 160Wh; power banks with a rated energy of more than 100Wh but not more than 160Wh must be approved by the airline and must not exceed two.

　　Third, it is strictly forbidden to carry power banks with unclear markings.

　　IV. It is strictly forbidden to use the power bank during the flight.

　　Fifth, it is strictly forbidden to carry power banks for non-personal use.

　　Those who violate the above provisions will be dealt with severely by the public security organs according to the circumstances and in accordance with relevant national laws and regulations.

　　The above provisions also apply to the crew.

　　From September 22 to September 27, the 2023 Hybrid Electric Vehicle Extreme Challenge, the first domestic hybrid car exclusive event jointly launched by China Automotive Xinke and Kunming Inspection Center, was successfully concluded in Yunnan. The competition items involved a number of key indicators to measure the buying point of hybrid cars, such as pure electric cruising mileage, power loss fuel consumption, high-speed real energy consumption, and plateau mountain extreme energy consumption. During the six-day challenge, this "AI intelligent electric hybrid car" Geely Galaxy L6, which is dedicated to building a new generation of intelligent electric hybrid comfort benchmarks, played a stable role in all aspects and lived up to expectations. It won the championship of the compact plug-in hybrid car group and the single championship of plateau extreme energy consumption in one fell swoop. At the same time, in 6 of the 10 test items (idling vibration, 60km/h and 80km/h power loss constant speed driving noise, pure electric battery life, power loss energy consumption, limit energy consumption), defeated the remaining 18 participating models and won the championship.

　　"Honors" at the same level: Low key can play, truebattery lifeSuper official data

　　The Geely Galaxy L6 participating in the challenge is a 125km starship of 2023. It uses a new generation of Raytheon hybrid 8848 power system, is equipped with a 1.5T hybrid dedicated engine with a maximum power of 120kW and a peak torque of 225N · m, and is matched with a 3-speed variable frequency electric drive DHT Pro. The maximum speed can reach 247km/h. In the plateau pure electric cruising range test, Geely Galaxy L6 delivered a perfect answer. After actual testing, Geely Galaxy L6 has a true cruising range of 131km, even 6 kilometers more than the official CLTC, which is really surprising and reflects the brand’s usual low-key and pragmatic.

　　At the same time, Geely Galaxy L6’s full-speed power and stable output performance have also been verified in long-distance battery life and fuel consumption tests. The test road in the competition is connected to many mountains, the road is long and winding, and there are many curves. With the McPherson-style front suspension and the rare multi-link independent rear suspension in the same class, Geely Galaxy L6 has precise steering and stable entry into corners. After exiting the corners, it can quickly increase to the best speed, achieving a delicate balance of speed and control.

　　Single champion: extreme fuel consumption, the lowest in the audience, focusing on a cost-effective

　　In addition to pure electric cruising, another important indicator for examining hybrid models is naturally fuel consumption. The big racing car tested the fuel consumption of the participating vehicles in the standard driving mode under the same conditions as the air conditioner setting of 25 ° C and the automatic air volume. Geely Galaxy L6 led the same class with a result of 4.74L/km.

　　The competition also tested the total energy consumption of the participating vehicles under the extreme working conditions of round-trip altitude climbing, long slope and steep descent of about 359 kilometers. In this project, Geely Galaxy L6 won the individual championship with a minimum extreme energy consumption of 3.94L/km. Geely Galaxy L6 is equipped with three-speed variable frequency DHT Pro, P1/P2 motor and an engine with 20 working modes and turbocharged suction. It has a wide range of working conditions and can provide the best power solution for different car scenarios. At a time when the popularity of self-driving travel in high-altitude areas continues unabated, the economy and convenience of Geely Galaxy L6 are undoubtedly very attractive to consumers.

　　Smart Cockpit Blessings:Enjoy safety quietly, praise from drivers who travel long distances

　　It is worth mentioning that the ride of the Geely Galaxy L6 is also very comfortable. In the test of the NVH dimension of the competition, the sound pressure level of the interior noise of the Geely Galaxy L6 at 60km/h and 80km/h under power loss is only 54.23dB and 57.09dB, which is the lowest in the same group. The idle vibration is also lower than that of the same group of models, and the NVH level is leading the same class.

　　In addition, Geely Galaxy L6 leads the same level in length and width, coupled with the use of silver-plated + LOW-E technology for shading and heat insulation double-dome canopy, spacious driving space. The whole system comes standard with 10.25-inch instrument + 13.2-inch central control screen + 16.2-inch co-driver screen three large screens, full-stack self-developed Galaxy N OS vehicle intelligence system, one-touch quick interaction, zero learning seconds to get started Android system, full scene visibility can be said, which greatly meets the various needs of users in driving. During the long journey of more than 1,000 kilometers, Geely Galaxy L6 industry’s first dual-partition marshmallow memory seat has strong wrapping, sedentary and not tired, and has also been well received by drivers. In terms of safety, Geely Galaxy L6 is based on the world’s leading new e-CMA intelligent electric hybrid architecture, with extremely strict standards. The proportion of thermoformed steel in the whole vehicle far exceeds that of the same level. The Aegis battery system is equipped to achieve battery protection and ensure the safety of the whole vehicle structure.

　　Overall, Geely’s Galaxy L6 has undergone comprehensive innovation in safety, performance, comfort, and intelligence, and its overall mechanical quality has surpassed that of its peers. The various achievements of the Hybrid Electric Vehicle Extreme Challenge confirm that this industry benchmark electric hybrid sedan is indeed trustworthy. Adhering to the concept of "building an intelligent boutique car for everyone", Geely undoubtedly has high hopes for the Galaxy L6, and has indeed achieved multiple "firsts". More highlights and details about the model need to be experienced and discovered by consumers in person.

　　"Your AI data manager, help you do business together!" Recently, the Ele.me retail merchant SAAS platform "Aoxiang" officially released the "AI business assistant" function for merchants in the retail industry. Through this new business tool, merchants can intelligently generate various business key reports and key data, further enhance business capabilities and seize business opportunities.

　　This business management tool driven by artificial intelligence technology integrates advanced natural language processing, intelligent decision support and deep learning capabilities, which can provide businesses with a full range of business services including weekly report push, index change attribution, competition for business alignment, and market trend selection.

　　AI technology solves business pain points

　　"Hello, I am your AI business assistant, welcome to our platform. I will provide you with weekly report analysis, intelligent interpretation and market opportunity suggestions to make your business decisions more informed." On Monday morning, Mr. Xu, the retailer of Ele.me warehouse store, opened the new version of the Aoxiang APP and found that a new business tool was launched in the upper right corner. After clicking the "View Business Weekly Report" button, the business status of his store in the past week was clear at a glance.

　　The reporter found that the intelligent weekly report generated by the "AI business assistant" not only includes core indicators such as the valid order amount of the store, the number of valid orders, and the estimated gross profit of the store, but also includes intelligent interpretation and overall business suggestions provided by artificial intelligence based on the business operation. For example, through the operation change indicators, the "AI business assistant" will judge which indicators may be abnormal according to the historical data of the merchant. The merchant can see the data fluctuations about the net sales volume of the store, the number of goods on the shelves, the original price of the delivery fee, and the platform bears the delivery fee. Further check the reasons for the fluctuation of the data, and adjust the business strategy accordingly.

　　In addition to its own business diagnosis, the "AI business assistant" can also help merchants further analyze the surrounding business opportunities in the business district where the store is located, as well as the overall market opportunities.

　　According to the introduction, through the "AI operation assistant", merchants can query the corresponding business district according to the specific store, find the surrounding TOP stores, and compare the monthly sales of goods in the shelf rate, out-of-stock return rate, product low price rate, performance timely rate, and manual reply timely rate. These analyses can provide store managers with operational optimization suggestions and the fastest way to grow orders.

　　In addition, the "AI management assistant" can also mine the most promising products in the business circle where the store is located, and provide merchants with product opportunity analysis and product selection suggestions. At the same time, the AI will also provide operators with corresponding sales strategies based on the data.

　　The first batch of application merchants: AI is really fragrant

　　The reporter learned that, as an all-channel service SAAS platform for Ele.me retail merchants, Aoxiang has been the first in the industry to launch AI business tools after researching operators of different sizes, different industries, and different entry times. On the basis of the large model, the "AI business assistant" can disassemble the key data of store operations, and combine natural language to provide merchants with logical and clear data indicators and easy-to-understand business suggestions in a conversational mode.

　　The first batch of merchants to use "AI business assistants" also expressed "AI really fragrant" in the face of convenient new functions.

　　"The weekly report is really practical, and there is no need to summarize the data one by one for the weekly store review." Welcome Supermarket operates dozens of stores, and the person in charge of its operation said that the "AI management assistant" can quickly locate the problem through the index change, directly saving itself the time to locate the store problem. In addition, the indicators of the surrounding competition analysis are also selected accurately, which is the core focus of its daily operation.

　　Beiku Convenience said that although the number of stores it operates is not large, it feels that "weekly reports and data changes are very helpful" after using the AI business assistant, which allows merchants to quickly extract effective indicators from complex indicators and summarize them. The presentation of data and suggestions is also very intuitive.

　　"In the process of daily serving retail merchants, especially small and medium-sized merchants, we feel that merchants have obvious pain points in starting their business, obtaining industry data and analyzing business reports. Now through artificial intelligence data acquisition and analysis, merchants can effectively solve these pain points." Wang Xiaojie, head of Ele.me "AI business assistant", said that this new function is currently open to all Aoxiang merchants. Merchants can use the latest version of the Aoxiang APP. In the future, "AI business assistant" will also be gradually opened to all merchants in the retail industry in the form of tools to help merchants see their own business data.

　　On April 18, the First Chongqing Second Symposium on the Integration of Ideological and Political Education in the Shuangcheng Economic Circle of Chengdu and Chongqing was held in Dadukou District, Chongqing.

　　"Why choose Dadukou?" On May 23, 2023, during the fourth "National Mainstream Network Media Chongqing Education Tour" event, more than 40 mainstream network media reporters from across the country walked into Dadukou and asked questions.

　　It is understood that in recent years, Dadukou District has closely focused on the fundamental task of building morality and cultivating people, focusing on key issues such as "building an ideological and political curriculum system that keeps pace with the times" and "strengthening the ideological and political teaching team". From the perspective of the region as a whole, it has explored the overall promotion and implementation strategy of building ideological and political courses in large, medium and primary schools, established an education system of "Party building leads the course of ideological and political" in the region, and further promoted the integration of ideological and political education in large, medium and primary schools in the region, creating a "Dadukou model" for regional ideological and political education.

Chongqing large, medium and small ideological and political courses integration construction teaching seminar exchange display

　　Same Direction: Raising Awareness and Deeply Understanding the Importance of Ideological and Political Education

　　Dadukou District has thoroughly implemented the discussion of "Ideological and political courses are the key courses for implementing the fundamental task of building morality and cultivating people", and invited experts from the Municipal Academy of Education Sciences and relevant universities to carry out theoretical training on "Party building leadership, ideological and political courses" and follow-up guidance in the whole process, so as to effectively improve the theoretical understanding and practical ability of teachers in the district.

　　After the release of the "Several Opinions on Deepening the Reform and Innovation of Ideological and Political Theory Courses in Schools in the New Era" by the General Office of the Central Committee of the Communist Party of China and the General Office of the State Council, Dadukou District, under the guidance of experts from the Municipal Academy of Educational Sciences and relevant universities and colleges of Marxism, took "coordinating the integrated construction of ideological and political courses in large, medium and primary schools" as one of the basic principles for the reform and innovation of regional ideological and political courses, and enhanced the "new efficiency" of bacon soul casting for

　　Same frequency: active practice, in-depth planning of ideological and political education curriculum system

　　Dadukou District actively explores the establishment of a party building education mechanism, adheres to the principle of "party building leads, curriculum ideology and politics" in all disciplines, and forms a number of party building and united front characteristic courses to ensure that the party branch leads the ideological and political construction of the course.

　　In terms of actively building special party building projects, Dadu District closely integrates party building with curriculum ideological and political teaching and research activities, and around the theme of "curriculum ideological and political", it has carried out in-depth classroom teaching training, high-quality class competitions, thesis and case evaluation, homework design evaluation, project research and other actions. It has created a series of special party building projects of "1 (District Teacher Training College) + N (Primary and Secondary Schools) Party Building + Teaching and Research", which projects to drive teachers’ awareness and ability of curriculum ideological and political.

　　For cultivating the typical ideological and political model of the tree selection course, we will give full play to the exemplary and leading role of the ideological and political education model school, excellent teaching team, and excellent course examples, and cultivate a group of "party building leadership, curriculum ideological and political" backbone teachers in the form of "dual training" in the form of demonstration, assistance, and bonding. This will drive the integration of ideological and political education in primary and secondary schools in the region.

　　At the same time, enrich and enrich the content of ideological and political education, and integrate into the "1 + 2 + X" series of ideological and political courses, patriotic love for the party and revolutionary traditional education, Chinese excellent traditional cultural education, national sovereignty education, rule awareness and democratic rule of law education, daily life civilization education, ecological ethics education, international perspective education, labor education, mental health education and other elements to form a broad vision of ideological and political courses and strengthen the advantages of curriculum education.

Cross-regional Primary School Ideological and Political Course Construction Seminar

　　Peers: keep integrity and innovation, deeply empower the professional growth of ideological and political teachers

　　Dadukou District hired experts and scholars to teach teachers of ideological and political courses to improve the effectiveness of training. The "Curriculum Ideology and Politics" workshop for primary and secondary political disciplines carried out a series of activities such as special lectures, discussion exchanges, teaching design, paper selection, and high-quality course competitions, forming a regional "Great Ideology and Politics" atmosphere, which promoted the great improvement of ideological and political teachers in terms of professional ability, theoretical literacy, and teacher ethics and ability. Pay equal attention to training, and press the "fast-forward button" for the growth of ideological and political teachers.

　　At the same time, establish and improve the system of access, exit, rotation training, and lesson preparation for teachers of ideological and political courses in primary and secondary schools, explore the formation of the "554" mixed teacher training model and the "double-layer three-ring five-mechanism" strategy, and adopt the "123N" immersive training method. A relatively complete teacher training system has been formed, ensuring that the "big ideological and political" training of "ideological and political courses everywhere in the classroom" has strengthened the kinetic energy and focused on development, realized the development of training and training, and paved the "fast lane" for the growth of ideological and political teachers.

　　Not only that, Dadukou District also attaches great importance to training practical task design, strengthening theme research to improve teaching and research capabilities, optimizing the training staff’s echelon training, doing a good job in regular teaching and research in the form of case study, "mentoring" to do practical grinding lessons and prepare lessons, etc., effectively transforming training efficiency into teachers’ classroom teaching ability, promoting teachers’ professional development with high quality, ensuring that the "salt" of ideological and political education is subtly integrated into the "water" of classroom teaching, and achieving the "big ideological and political" goal of "curriculum doors talk about ideology and politics". Practice is parallel, opening a "new track" for the growth of ideological and political teachers.

　　Regional Ideological and Political Quality Course Competition

　　Synchronization: Collaborative development, in-depth implementation of the overall promotion strategy of ideological and political education

　　Dadukou District has improved the integrated teaching and research within and between sections, and within and between schools, forming a new type of ideological and political course practice education model that is organically unified with "in-class + out-of-class", "in-school + out-of-school", "perceptual + rational" and "online + offline". It has formed a three-dimensional mixed training model for ideological and political courses in elementary and high schools in the region.

　　The classic cases of regional teachers’ ideological and political education teaching were selected as the typical experience of the Ministry of Education for 6 times, and the first lesson of excellent teaching resources "Tree of Yidu" was pushed by the Xuexi Qiangguo platform, and the click through rate reached more than 60,000 times; the Municipal Academy of Education’s ideological and political research activities showed 12 excellent cases of ideological and political courses, and 10 ideological and political micro-lessons were selected.

　　Hosted and co-organized a series of activities such as "Yunnan, Guizhou, Sichuan and Chongqing Cross-regional Primary and Secondary School Ideological and Political Course Teaching Seminar", the first "Chongqing University, Middle and Primary School Ideological and Political Course Integration Construction Teaching Seminar", "Ecological Civilization Construction Theme Education Exchange Exhibition Activity", "Chongqing Primary School Science Curriculum Ideological and Political Exhibition and Exchange Activity", etc., with high social reputation.

　　The 2021 Chongqing Teaching Achievement Award "Development and Implementation of Regional Rule of Law Course <" Sister Sha "Entering Campus >" and the first prize "Research on Regional Overall Promotion Practice of Ideological and Political Courses in Primary and Secondary Schools" have been selected for the 2022 National Teaching Achievement Award. Among them, "Development and Implementation of Regional Rule of Law Course <" Sister Sha "Entering Campus >" has been investigated and instructed more than 20 times by leaders such as the National People’s Congress, the National Committee of the Chinese People’s Political Consultative Conference, and the Supreme People’s Procuratorate, and has been written into the reports of the Supreme People’s Procuratorate for many times.

　　Together with Chongqing Normal University, the Municipal Academy of Education and Sciences and other units, it has become a key construction community for the integration of ideological and political courses in large, medium and primary schools in Chongqing, and will further explore the way and path of building a "large, medium and primary school ideological and political education integration" teaching system and practical teaching of ideological and political education in the new era, promote the high-quality and sustainable development of ideological and political education, and explore the Dadukou model of regional integration and collaborative innovation of ideological and political courses in large, medium and primary schools.

　　At present, "multi-dimensional integration, education Dadu" is becoming a beautiful business card for the people’s satisfactory education in Dadukou District. Dadukou District will take the opportunity of the integration of large, medium and small ideological and political construction, closely combine the construction goal of "Park Dadukou, Colorful Art Bay", adhere to the integration of the whole region, participate in the whole process, and promote the coordinated development, integrated development and integrated development of large, medium and primary schools’ ideological and political education in an all-round way. It will further broaden the new driving force of development, improve the new atmosphere of development, and innovate the new development mechanism, so as to provide assistance for the high-quality development of the ideological and political integration of large, medium and primary schools in the

On November 29, Meituan announced that since December 1, it plans to buy back the company’s shares with a total amount of no more than 1 billion US dollars.

Meituan believes that the share repurchase demonstrates the company’s confidence in its business outlook and prospects. The board believes that the company’s existing financial resources are sufficient to support the share repurchase while maintaining a sound financial position.

According to Meituan’s latest third quarter results announcement for 2023, the company’s quarterly revenue was 76.50 billion yuan, an increase of 22.1% year-on-year; adjusted profit was 5.73 billion yuan, an increase of 62.4% year-on-year.

Editor, Li Yan

Proofreading, Liu Baoqing

foreword

Malignant multiple myeloma(multiple myeloma ； MM) is a kind ofwithMalignant disease characterized by massive proliferation of monoclonal plasma cells in bone marrow. B cell maturation antigen (BCMA) is highly expressed on the surface of MM cells. In the past few years, great progress has been made in various BCMA targeted immunotherapy for recurrent/refractory MM patients, including anti-BCMA monoclonal antibodies, antibody-drug conjugates (ADC), bispecific T cell binders (BITE) and chimeric antigen receptor adoptive T cell therapy (CAR-T). The 63rd annual meeting of American Hematology Society updated some information about the application of BCMA in MM, and based on this annual meeting, the related contents of this paper were sorted out [1].

Immunotherapy targeting BCMA: (1)ADC; 　 (2)CAR-T; 　 (3)BiTE;　

copywriter |　NING

BCell maturation antigen (BCMA)

Also known as TNFRSF17, it is a member of TNF-receptor family, and is called tumor necrosis factor receptor superfamily 17. This receptor is expressed on the surface of B lymphocytes and plasma cells, and is a marker protein of B lymphocyte maturation. Under physiological conditions, BCMA is mainly expressed in plasma mother cells and terminally differentiated plasma cells (PC). Under pathological conditions,BCMA Almost in all MM Tumor cell line (80%–100%) are expressed.The number of BCMA on the surface of malignant PC is much higher than that of conventional PC, which explains why BCMA target has become a battleground for major biological enterprises.

Monoclonal antibody targeting BCMA

SEA-BCMAIt is a new humanized non-fucosylation. IgG1 mAb. The working mechanism of SEA-BCMA may include blocking BCMA activation and its downstream proliferation signal pathway, regulating antibody-dependent cell phagocytosis and enhancing antibody-dependent cytotoxicity.

Its clinical phase I trial (SGNBCMA-001; The preliminary results of NCT03582033) show that it has good safety and combination potential: SEA-BCMA also shows encouraging treatment duration and initial anti-tumor activity in the advanced R/R MM population who have received a lot of treatment before.

Source: blood (2021) 138 (Supplement1): 2740.doi: 10.1182/blood-2021-146047.

Bispecific T Cell cement (BITE)

BiTEs can simultaneously target BCMA on MM tumor cells and CD3ε domain of TCR on T cells. After T cells are combined with myeloma cells, cytotoxic T cells can be activated and secrete cytotoxic factors, thus producing cell killing effect.This part is still in Ⅰ at present./Phase ii.

The following table summarizes the clinical data of bispecific antibodies against BCMA, among which the BiTE bispecific type of BCMA×CD3 is the most common.

Novel trispecific antibody drugs

Researchers are no longer satisfied with treating patients with R/R MM through dual-target therapy.HPN217, an extended half-life (median serum half-life:74 Hours) three specificity. T Cell activation construct (TriTAC)It simultaneously targets BCMA and CD3ε (redirected T cells), and adds serum albumin to prolong the half-life, which can exert cytotoxic effect on myeloma cells.Currently working onR/R MM of 1 /2 Phase I clinical trial for evaluation (NCT04184050). Here are some preclinical data.

Legend: HPN217 mediates the killing effect of autologous T cells of NCG mice on BCMA-dependent/primary MM cells.

Source: blood (2021) 138 (Supplement1): 1185.doi: 10.1182/blood-2021-151880.

CDR101(CDR-lifeCompany’s products)Is simultaneous targeting.CD3、BCMAandPD-L1The trispecific antibody,T cells can be induced into tumor cells expressing BCMA, and the immunosuppressive effect caused by the interaction between PD-L1 and PD-1 can be blocked at the immune synaptic site. Compared with BCMA × CD3 bispecific drugs, CDR101 leads to at least a tenfold increase in T cell-mediated tumor cell lysis, and performs better than the combination of PD-L1 inhibitor and BCMA × CD3 bispecific drugs.CDR101 It may become a new ready-made treatment, providing a more lasting response and a higher cure rate. CDR101 Has excellent drug-like characteristics, high stability and high stability.CHOHigh yield of expression.Based on these findings, new trispecific immunotherapy drugs have high clinical potential and promising clinical application [2].

Antibody drug conjugate (ADC)

After recognizing BCMA on the cell surface, ADC internalizes it into myeloma cells. Through the degradation of lysosomes or endosomes, the payload is released, causing cytotoxicity.

Belantamab mafodotin (GSK2857916)Is targeted by humanization.BCMA IgG1 andMMAF(tubulin polymerization inhibitor). Belantamab mafodotin was approved by the US Food and Drug Administration (FDA) in 2020 to treat patients with R/R MM.This is the first target approved for listing.BCMAimmunotherapy,A multicenter phase II clinical study (NCT03525678) confirmed that the recommended regimen for patients was 2.5 mg/kg, once every three weeks, but the toxicity of the drug was mainly manifested in thrombocytopenia and pericorneal lesions, such as microcystic epithelial changes or superficial punctate keratopathy. In addition to belantamab mafodotin, several other ADCs targeting BCMA, such as AMG 224, MEDI2228 and HDP-101, have also conducted many preclinical or clinical studies at different stages.

Legend: Incidence rate of adverse events caused by Belantamab mafodotin at 2.5 mg/kg and Q3W.

Antibody drug conjugate (ADC) joint test.

In the joint experiment, there are two schemes: belantamab+DEX (dexamethasone) and belantamab+DEX+POM.

belantamab(2.5 mg/kg Q3W) and DEX(20-40 mg Q1W,threeCycle) jointAfter use, the objective remission rate (ORR) was 46%, the complete remission rate (CR) was 14%, the median progression-free survival (PFS) was 4.9 months, and the median overall survival (OS) was 7.4 months. The incidence of AEs from high to low is anemia (83%), keratopathy (82%; Gr3/4: 56%), thrombocytopenia (70%) and so on.

belantamab+DEX+POMUnion ofIn the experimental scheme, the ORR was 88.9%(48/54), and the CR and PR rates were 24.1%(13/54) and 20.4%( 11/54) respectively. However, keratopathy (96.9%) was also the most common AE, and 56.7% of such patients had reached Gr 3/4. These two studies show that POM and DEX may have a positive effect on the curative effect of belantamab. howeverKeratosis is still a challenge in the treatment process.

Legend: Detailed rules and results of belantamab+DEX (Dexamethasone) joint trial scheme.

Source: Blood 2021; 138 (Supplement 1): 1642. doi: https://doi.org/10.1182/blood-2021-149791

CAR-Ttherapy

nowTwo CAR-T therapies based on BCMA have been approved for marketing.And is used for treating patients with multiple myeloma.

Source: "CAR-T therapy targeting BCMA"

7.1

Cilta-cel (Carvykti) for Orense injection.

Sidaki Orense injection(Cilta-cel,Carvykti) yes2022year2moon28Listed in China (NMPAApproved for listing/FDAFormal approval) targeting.BCMAofCAR-TCell products, jointly developed by Janssen and Legendary Bio, Legendary Bio owns 70% interests in Carvykti Greater China and 50% interests overseas.

In CARTITUDE-1 trial, the overall remission rate was 97%, the 18-month progression-free survival rate was 66%, and the 2-year progression-free survival rate was 61%. The 18-month overall survival rate is 81%, and the 2-year overall survival rate is 74%. Compared with similar products, this data is very gratifying. According to the latest news from Kingsley, the sales of the legendary BCMA CAR-T new drug Carvykti in the first half of the year was 24 million US dollars.

7.2

Abecma（Ide-cel）

2021yearthreemoon26Day,FDAapproveBaishimei SquibbAbecma(Ide-cel)be listedAbecma is also a BCMA-oriented CAR-T cell therapy, which is customized from patients’ autologous T cells. Clinical data show that the overall remission rate of all patients is 72%, of which the complete remission rate is 28%; Even for patients who have received various regimens, the remission rate of Abecma still reaches 72%, and this remission is very lasting, and 65% of patients are over 12 months.

Legend: preparation principle of Abecma

7.3

Iqalunsei injection

In addition, June 2, 2022Reindeer biology/Xinda biologyAnnounce BCMA CAR-T therapyIqalunsei injectionThe listing application was obtained.NMPAAccepted, it is expected to become the first domestic independent research and development of the whole process.CAR-Ttherapy. The clinical research data reported at the 63rd ASH annual meeting in 2021 showed that the overall remission rate (ORR) was 94.9%, and the complete remission rate/strict complete remission rate (CR/sCR) was 58.2%, showing the excellent safety and effectiveness of Iqalunsei injection.

Source: NMPA official website

7.4

The clinical trial of CAR-T therapy targeting BCMA is as follows

summary

Judging from the listing situation,Belantamab mafodotin (GSK2857916) is composed of humanized targeting BCMA IgG1 and MMAF (tubulin polymerization inhibitor), which is the first targeted BCMA immunotherapy approved for marketing. At present, there are two CAR-T therapies that have been put on the market, developed by Bristol-Myers Squibb respectively.Abecma(Ide-cel), developed in cooperation with Janssen)/ Legendary Biology.Sidaki Orense injectionFrom the data point of view, the latter effect is better, the ORR is increased from 72% to 97%, and other indicators are relatively better. On June 2nd, 2022, Reindeer Bio/Cinda Bio announced BCMA CAR-T therapy.Application for marketing of Iqalunsei injectionIt has also been accepted by NMPA, and it is expected to become the first CAR-T therapy independently developed in the whole process in China. Let us wait and see! From the therapeutic point of view, CAR-T therapy is at the forefront in terms of clinical data and market situation, but we can’t simply judge the advantages and disadvantages of these products. For example, better anti-BCMA CAR-T cell therapy requires more complicated preparation conditions and more expensive treatment costs, which are unbearable for ordinary families. Therefore, while continuing the existing research, it is necessary to study the potential mechanism affecting the curative effect in order to optimize BCMA targeted immunotherapy.

Legend: Comparison of clinical efficacy between different immunotherapy products targeting BCMA (see [1] for specific clinical data).

reference data

[1]Targeting BCMA to Treat Multiple Myeloma: Updates From the 2021 ASH Annual Meeting. Front Immunol. 2022 Mar 7; 13:839097. doi: 10.3389/fimmu.2022.839097. PMID: 35320942; PMCID: PMC8936073.

[2] Blood 2021; 138 (Supplement 1): 1583. doi: https://doi.org/10.1182/blood-2021-152160

[3] Blood 2021; 138 (Supplement 1): 1642. doi: https://doi.org/10.1182/blood-2021-149791

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　　() The Record Form of Investor Relations Activities was released on April 12, and the company was investigated by two institutions on April 11, 2023. The types of institutions are other securities companies. The main contents of investor relations activities are introduced:

　　Q: What was the sales volume of BYD and Tengshi brand in March?

　　A: BYD sold 207,080 vehicles in March 2023, including 206,089 passenger cars, up 97.5% year-on-year; There are 13,312 passenger cars exported. BYD Tengshi D9 ranked first in the "Sales List of New Energy Luxury MPVs with an average transaction price of 415,000" for three consecutive months with a score of 10,398 units (up 42% from the previous month), and continued to consolidate its position as a "new benchmark for the value of new energy luxury MPVs in China".

　　Q: What’s the feedback from BYD Seals?

　　A: Since its listing, BYD Seal has become an explosive model in the sports market with its excellent quality and leading strength. As the world’s first production car equipped with CTB battery body integration technology, Seal is not only BYD’s practical exploration of the next generation of electric vehicles, but also the realization of its innovative technology in products, and it is also BYD’s masterpiece in the advanced technology field of electric vehicles. On April 7th, CCTV’s third "China Automobile Fengyun Festival" came to a perfect conclusion, and BYD seal, a marine leopard, won the highest prize "Jury Award" and became the biggest winner of this "Festival". This award is not only a high recognition of BYD Seals, but also an authoritative hardcore endorsement comparable to the purchase guide.

　　Q: What is the overseas response of BYD models?

　　A: BYD has actively deployed its overseas business, and has successively entered the passenger car market in Australia, Colombia, Brazil, Singapore, Costa Rica, Thailand and other countries, which has been widely concerned and loved by local consumers. Recently, Thailand AutoLife official website data shows that in March, the number of BYD ATTO3 cards reached 2,434, winning the title of pure electric vehicles in Thailand for the third time in a row. In the first quarter, the number of BYD ATTO3 licenses was 5,542, accounting for 37.5% of the total number of pure electric vehicles in the first quarter, and it continued to lead the pure electric passenger car market in Thailand.

　　Q: Please introduce BYD’s design concept?

　　A: Since Wangwang brand appeared, its subversive core technology has been widely concerned, and the discussion has always been hot. At the same time, highly recognizable product design has also received great attention. Looking up at the car design inspiration comes from the universe, which is a space that contains infinite time, energy and emotion. The place leading to this space is called "dimension door", which is the most recognizable part of looking up to the brand-new family visual identity of the car, hoping to bring a brand-new visual experience to users. Looking up at the front face design of U8 is the most recognizable part of modeling. Dimension door’s family-style design language is integrated. A large area of front and rear lighting design creates a visually full sense of volume. Headlight lines outline the image of dimension door, presenting the ultimate sense of science and technology and futurity. Driving outdoors in the wilderness and in urban traffic shows its recognition. The local light-emitting unit follows the lattice air intake grille, and the diamond light particles are regularly arranged, which changes the gorgeous lighting effects in the scenes of unlocking and welcoming guests, so that every departure is full of ritual.

　　Q: Please introduce the highlights of BYD’s cloud technology?

　　A: On April 10th, BYD released a new energy-specific intelligent body control system-Yunqi. The intelligent body control system of Yunqi is developed by BYD, which also indicates that BYD has become a China automobile enterprise that can independently master the intelligent body control system. The product matrix of Yunqi includes Yunqi -C, Yunqi -A, Yunqi -P and other products, which will greatly enhance the driving experience of consumers from the dimensions of comfort, control, safety and off-road. Yunbi can effectively restrain the change of body posture, greatly reduce the risk of vehicle rollover and reduce the sitting displacement of drivers and passengers. At the same time, the cloud chariot system can effectively protect the car body under complex road conditions such as snow, mud and water, avoid the collision damage of the whole car caused by terrain, improve driving comfort and safety, and realize the double protection of people and cars; BYD Co., Ltd. is mainly engaged in automobile business, mobile phone parts and assembly business, rechargeable battery and photovoltaic business, including new energy vehicles and traditional fuel vehicles, and actively expands the business field of urban rail transit. The company’s main products are rechargeable batteries and photovoltaics, mobile phone components and assembly, automobiles and related products. BYD’s leading position in the global new energy vehicle field. In 2019, BYD’s new energy vehicle product structure was further improved, and its sales volume still ranked among the top in the world.

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