On April 18, the First Chongqing Second Symposium on the Integration of Ideological and Political Education in the Shuangcheng Economic Circle of Chengdu and Chongqing was held in Dadukou District, Chongqing.

　　"Why choose Dadukou?" On May 23, 2023, during the fourth "National Mainstream Network Media Chongqing Education Tour" event, more than 40 mainstream network media reporters from across the country walked into Dadukou and asked questions.

　　It is understood that in recent years, Dadukou District has closely focused on the fundamental task of building morality and cultivating people, focusing on key issues such as "building an ideological and political curriculum system that keeps pace with the times" and "strengthening the ideological and political teaching team". From the perspective of the region as a whole, it has explored the overall promotion and implementation strategy of building ideological and political courses in large, medium and primary schools, established an education system of "Party building leads the course of ideological and political" in the region, and further promoted the integration of ideological and political education in large, medium and primary schools in the region, creating a "Dadukou model" for regional ideological and political education.

　　

Chongqing large, medium and small ideological and political courses integration construction teaching seminar exchange display

　　Same Direction: Raising Awareness and Deeply Understanding the Importance of Ideological and Political Education

　　Dadukou District has thoroughly implemented the discussion of "Ideological and political courses are the key courses for implementing the fundamental task of building morality and cultivating people", and invited experts from the Municipal Academy of Education Sciences and relevant universities to carry out theoretical training on "Party building leadership, ideological and political courses" and follow-up guidance in the whole process, so as to effectively improve the theoretical understanding and practical ability of teachers in the district.

　　After the release of the "Several Opinions on Deepening the Reform and Innovation of Ideological and Political Theory Courses in Schools in the New Era" by the General Office of the Central Committee of the Communist Party of China and the General Office of the State Council, Dadukou District, under the guidance of experts from the Municipal Academy of Educational Sciences and relevant universities and colleges of Marxism, took "coordinating the integrated construction of ideological and political courses in large, medium and primary schools" as one of the basic principles for the reform and innovation of regional ideological and political courses, and enhanced the "new efficiency" of bacon soul casting for

　　Same frequency: active practice, in-depth planning of ideological and political education curriculum system

　　Dadukou District actively explores the establishment of a party building education mechanism, adheres to the principle of "party building leads, curriculum ideology and politics" in all disciplines, and forms a number of party building and united front characteristic courses to ensure that the party branch leads the ideological and political construction of the course.

　　In terms of actively building special party building projects, Dadu District closely integrates party building with curriculum ideological and political teaching and research activities, and around the theme of "curriculum ideological and political", it has carried out in-depth classroom teaching training, high-quality class competitions, thesis and case evaluation, homework design evaluation, project research and other actions. It has created a series of special party building projects of "1 (District Teacher Training College) + N (Primary and Secondary Schools) Party Building + Teaching and Research", which projects to drive teachers’ awareness and ability of curriculum ideological and political.

　　For cultivating the typical ideological and political model of the tree selection course, we will give full play to the exemplary and leading role of the ideological and political education model school, excellent teaching team, and excellent course examples, and cultivate a group of "party building leadership, curriculum ideological and political" backbone teachers in the form of "dual training" in the form of demonstration, assistance, and bonding. This will drive the integration of ideological and political education in primary and secondary schools in the region.

　　At the same time, enrich and enrich the content of ideological and political education, and integrate into the "1 + 2 + X" series of ideological and political courses, patriotic love for the party and revolutionary traditional education, Chinese excellent traditional cultural education, national sovereignty education, rule awareness and democratic rule of law education, daily life civilization education, ecological ethics education, international perspective education, labor education, mental health education and other elements to form a broad vision of ideological and political courses and strengthen the advantages of curriculum education.

　　

Cross-regional Primary School Ideological and Political Course Construction Seminar

　　Peers: keep integrity and innovation, deeply empower the professional growth of ideological and political teachers

　　Dadukou District hired experts and scholars to teach teachers of ideological and political courses to improve the effectiveness of training. The "Curriculum Ideology and Politics" workshop for primary and secondary political disciplines carried out a series of activities such as special lectures, discussion exchanges, teaching design, paper selection, and high-quality course competitions, forming a regional "Great Ideology and Politics" atmosphere, which promoted the great improvement of ideological and political teachers in terms of professional ability, theoretical literacy, and teacher ethics and ability. Pay equal attention to training, and press the "fast-forward button" for the growth of ideological and political teachers.

　　At the same time, establish and improve the system of access, exit, rotation training, and lesson preparation for teachers of ideological and political courses in primary and secondary schools, explore the formation of the "554" mixed teacher training model and the "double-layer three-ring five-mechanism" strategy, and adopt the "123N" immersive training method. A relatively complete teacher training system has been formed, ensuring that the "big ideological and political" training of "ideological and political courses everywhere in the classroom" has strengthened the kinetic energy and focused on development, realized the development of training and training, and paved the "fast lane" for the growth of ideological and political teachers.

　　Not only that, Dadukou District also attaches great importance to training practical task design, strengthening theme research to improve teaching and research capabilities, optimizing the training staff’s echelon training, doing a good job in regular teaching and research in the form of case study, "mentoring" to do practical grinding lessons and prepare lessons, etc., effectively transforming training efficiency into teachers’ classroom teaching ability, promoting teachers’ professional development with high quality, ensuring that the "salt" of ideological and political education is subtly integrated into the "water" of classroom teaching, and achieving the "big ideological and political" goal of "curriculum doors talk about ideology and politics". Practice is parallel, opening a "new track" for the growth of ideological and political teachers.

　　Regional Ideological and Political Quality Course Competition

　　Synchronization: Collaborative development, in-depth implementation of the overall promotion strategy of ideological and political education

　　Dadukou District has improved the integrated teaching and research within and between sections, and within and between schools, forming a new type of ideological and political course practice education model that is organically unified with "in-class + out-of-class", "in-school + out-of-school", "perceptual + rational" and "online + offline". It has formed a three-dimensional mixed training model for ideological and political courses in elementary and high schools in the region.

　　The classic cases of regional teachers’ ideological and political education teaching were selected as the typical experience of the Ministry of Education for 6 times, and the first lesson of excellent teaching resources "Tree of Yidu" was pushed by the Xuexi Qiangguo platform, and the click through rate reached more than 60,000 times; the Municipal Academy of Education’s ideological and political research activities showed 12 excellent cases of ideological and political courses, and 10 ideological and political micro-lessons were selected.

　　Hosted and co-organized a series of activities such as "Yunnan, Guizhou, Sichuan and Chongqing Cross-regional Primary and Secondary School Ideological and Political Course Teaching Seminar", the first "Chongqing University, Middle and Primary School Ideological and Political Course Integration Construction Teaching Seminar", "Ecological Civilization Construction Theme Education Exchange Exhibition Activity", "Chongqing Primary School Science Curriculum Ideological and Political Exhibition and Exchange Activity", etc., with high social reputation.

　　The 2021 Chongqing Teaching Achievement Award "Development and Implementation of Regional Rule of Law Course <" Sister Sha "Entering Campus >" and the first prize "Research on Regional Overall Promotion Practice of Ideological and Political Courses in Primary and Secondary Schools" have been selected for the 2022 National Teaching Achievement Award. Among them, "Development and Implementation of Regional Rule of Law Course <" Sister Sha "Entering Campus >" has been investigated and instructed more than 20 times by leaders such as the National People’s Congress, the National Committee of the Chinese People’s Political Consultative Conference, and the Supreme People’s Procuratorate, and has been written into the reports of the Supreme People’s Procuratorate for many times.

　　Together with Chongqing Normal University, the Municipal Academy of Education and Sciences and other units, it has become a key construction community for the integration of ideological and political courses in large, medium and primary schools in Chongqing, and will further explore the way and path of building a "large, medium and primary school ideological and political education integration" teaching system and practical teaching of ideological and political education in the new era, promote the high-quality and sustainable development of ideological and political education, and explore the Dadukou model of regional integration and collaborative innovation of ideological and political courses in large, medium and primary schools.

　　At present, "multi-dimensional integration, education Dadu" is becoming a beautiful business card for the people’s satisfactory education in Dadukou District. Dadukou District will take the opportunity of the integration of large, medium and small ideological and political construction, closely combine the construction goal of "Park Dadukou, Colorful Art Bay", adhere to the integration of the whole region, participate in the whole process, and promote the coordinated development, integrated development and integrated development of large, medium and primary schools’ ideological and political education in an all-round way. It will further broaden the new driving force of development, improve the new atmosphere of development, and innovate the new development mechanism, so as to provide assistance for the high-quality development of the ideological and political integration of large, medium and primary schools in the

As time goes by.

The news about iPhone 16 is getting more and more.

Because the appearance of iPhone has changed in recent years, it is just a small repair on the basis of iPhone 12.

Perhaps it was helplessness, or perhaps disappointment.

Ji Ge feels that everyone’s attention this year has focused on the imaging capabilities of the new iPhone.

Camera, stronger

In the previous inventory, Brother ****** mentioned it many times.

iPhone 16 Pro Max will feature a 48 million pixel 1/1.14-inch dual-layer transistor IMX903 custom main camera.

The final photo performance, can we fight with Huami OV and other real 1-inch outsole machines, although it is not easy to say.

But larger sensors will inevitably further enhance the paper strength of iPhone main camera.

However, this time, Apple has just embarked on the journey of super-bottom.

The domestic manufacturers that have taken the initiative do not plan to play with it.

I’m sure everyone has a feeling.

That is the main camera of the phone, at least from a physical perspective, almost to the end.

The current image flagship, in addition to the slightly different tone, has long been indistinguishable in terms of resolution and imaging quality.

In the past, everyone was struggling with who could shoot more clearly.

Now, everyone is competing to see who can shoot with more quality.

Coupled with the established thickness limit of the camera module, the main camera focal length had to be reduced from the previous 35mm and 28mm to 24mm and 23mm step by step…

Preview the body farther and farther inside the box.

Just like the "1x" lens, it is getting farther and farther away from "commonly used".

(35Mm | 28mm | 24mm)

Therefore, Brother Ji feels that rather than allowing mobile phone manufacturers to continue rolling in the main camera, it is better to raise the quality of other lenses, thereby increasing the average score of the entire camera image.

Looking at the Android side, they all began to pile up material in other lenses.

Here’s the good news.

Apple seems to have realized this and is willing to arrange for iPhone 16.

But here’s the bad news.

Apple is not upgrading the telephoto.

It’s ultra-wide-angle…

From the current revelations, Apple is likely to iPhone 16 Pro’s ultra-wide-angle lens, from the original 12 million pixels, to 48 million.

The previous year iPhone 14 Pro upgrade outsole, last year iPhone 15 Pro Max upgrade telephoto, this year iPhone 16 Pro upgrade ultra wide angle.

How to squeeze toothpaste every year.

Apple has always been okay.

As for why Ah Guo made a temporary move, he thought of upgrading the ultra-wide-angle lens that had no sense of presence in the entire ring in recent years.

It’s said that all of this is for that one function.

That’s right, it’s "Space Video".

Although shooting 4K video, only 9 million pixel resolution is enough.

But don’t forget, friends.

Now the 12 million-pixel ultra-wide-angle lens on the iPhone 15 Pro is digitally cropped and synchronized to the main camera’s field of view.

It is far from 4K resolution, which is 9 million pixel standard.

As we can see.

At present, iPhone 15 Pro, you can only shoot 1080p 30 frames of "space video".

After the iPhone 16 generation of ultra-wide-angle upgrades to 48 million pixels, it can form a dual 48 million system with the main camera.

Even if it has to be cut afterwards.

But it’s also enough to shoot higher-specification 4K space videos.

Therefore, it is foreseeable.

"Space video" will become the exclusive weapon of iPhone in the next era.

Coincidentally, the eighth brother, who was hiding under Brother Ji’s table, heard the words above and stuck his head out to express his disapproval:

"Brother Ji, the principle of shooting" space video "is not to borrow two parallel and adjacent cameras and use the parallax between the lenses to shoot?"

"Then, neither adjacent nor parallel iPhone number series, and how to pinch."

Camera, it’s vertical.

Look, when I asked you to study, you had to play glass beads, which exposed your IQ.

The mountain can’t come, I’ll go there.

You shoot diagonally, isn’t it over?

So…

Ahem, just kidding.

In order to popularize "space video" in the next system, if nothing else, iPhone digital series of cameras will also return to the previous vertical arrangement.

Just how to stand up, what to stand up like.

Is it back to the two big holes like iPhone 12, or back to the traffic lights like iPhone X.

So far, Apple has not had a clear answer.

Just 30 years in Hedong and 30 years in Hexi.

Apple’s design can really be described as "coming and going", arranged vertically, and actually came back so justifiably.

You see, it doesn’t bother him at all.

Brother Ji also has a no-prize quiz here.

If the fruit really adopts a vertical traffic light design similar to iPhone X.

You guys think.

Which wallgrass contestant will choose to follow up first?

The border is bent.

Go on.

In addition to the main camera and ultra-wide angle, both the iPhone 16 Pro and Pro Max will continue to use the 5X periscope telephoto.

In other words.

The iPhone that lost weight successfully last year will usher in the inevitable thickening journey at the end of this year~

It is said that in order to ensure the feel, the curvature of the screen edge of the new iPhone will become larger, which may eventually produce a similar effect.

The actual feel is unknown.

But the machine brother’s blind guess should feel similar to the Xiaomi Mi 14 Pro.

Since it comes to appearance.

Brother Ji recently saw a grapevine that Apple will also add a photo button dedicated to taking pictures on the iPhone 16.

At first, Ji Ge thought Apple was finally going to "fall" into the shape of Sony.

But when the machine brother read the full report, he felt jio.

Eh, something’s not quite right.

Fruit seems to really want to make iPhone into a camera…

Why would Brother Ji say that?

Don’t worry.

Do you think so.

First of all, it is reported that Apple wants to add "extremely advanced" touch adjustment to this button.

Specifically, the camera preview frame can be zoomed in and out by swiping left and right.

So this is a touch-activated version of the pulsator.

It’s not over yet!

In addition to sliding interaction, the button itself also supports mechanical pressing, which Apple has specifically divided into two pressing gears:

Tap to focus, and press hard to take a picture.

You see, isn’t this just a proper camera shutter button?

The Apple brand camera is just around the corner.

Although it is foreseeable that the addition of this shutter button will increase the usage of horizontal long videos and "space videos" to some extent.

But let’s just say.

Fruit, you have time to make room for iPhone to add a new button, and you are not willing to expand the battery a little more…

Performance, stronger

With the previous Pro version iPhone with the new U, the digital version iPhone with the previous generation U.

Apple has a strange conscience this year.

According to the news, the iPhone 16 series will use the A18 processor of the 3nm process.

It’s just a conscience, but not very conscientious.

An A18 chip.

Apple has released two versions of the A18 and A18 Pro.

The blind guess should be the same as before, using a full-blooded GPU on the Pro and a castrated GPU on the digital version.

It is not ruled out that there are also operations such as frequency reduction, peak limit, light chasing, etc.

Anyway, the final interpretation rests with Apple.

Anything is possible until iPhone 16 officially comes out in September.

But there is some good news.

That is iPhone 16 and 16 Plus will use 8GB random access memory in this generation because of the minimum memory threshold of the A18 processor, which is on par with the big brother Pro and Pro Max.

I didn’t expect it. I didn’t expect it.

In 2024, even iPhone collectively have 8GB of memory.

And Android manufacturers still have 8GB of fish that slip through the net.

Don’t laugh. It’s all about you.

Three stars!

Although the machine brother does not expect the new iPhone to be as amazing as iPhone 4s, iPhone 6, or lead the trend like iPhone X.

But as long as we can see iPhone steady and make up for the shortcomings a little bit, we can let our users see a few sincerity.

After all, it was spraying and scolding.

Fruit at least knows what we want, what we want to see, and what we want to use, and we make it up little by little.

Unlike the one next door.

No matter what Apple does, it just doesn’t cheat the poor.

And Samsung, even the rich are trapped.

It’s not for nothing that Samsung became Other at home.

Original, Digital Economy Consultant, Digital Economy Federation, included in the topic #Digital Economy Published 3

Digital Economy Headlines

1. The Fifth Session of the 13th National People’s Congress of Zhejiang Province was grandly opened, and version 2.0 of the "No. 1 Project" of the digital economy was implemented

On the morning of January 26, the Fifth Session of the 13th Provincial People’s Congress was grandly opened in Hangzhou. Listen to the government work report made by Governor Zheng Zhajie. The report pointed out that in 2020, the province’s GDP reached 6.4613 trillion yuan, an increase of 3.6% over the previous year, the general public budget revenue increased by 2.8%, and the income of urban and rural residents increased by 4.2% and 6.9% respectively. The report recommends that the main expected goals of the province’s economic and social development in 2021 are: GDP growth of more than 6.5%. The report proposes to implement the digital economy "No. 1 project" version 2.0. Vigorously promote digital industrialization, and the added value of the core industries of the digital economy will increase by more than 10%. Implement the "5G + Industrial Internet" project to form a large number of new technology fusion application scenarios.

2. The lithography giant posted the transcript: a high-end lithography machine is 1.10 billion yuan, and the profit margin is nearly 50%.

ASML, a leading Dutch lithography giant in the field of lithography machines, handed over a good 2020 report card. The financial report disclosed that ASML’s 2020 net sales 14 billion euros, gross profit margin was 48.6%, and net profit reached 3.60 billion euros.

The main players in the global lithography machine are ASML, Nikon and Canon, which account for 90% of the global market. ASML has a monopoly on the fifth-generation lithography machine EUV lithography machine due to its technological leadership. This kind of lithography machine is used to manufacture chips with advanced processes below 7nm.

In 2020, ASML sold 31 EUV lithography machines to the outside world, bringing in 4.50 billion euros (equivalent to 35.252 billion yuan) of revenue, accounting for 32.14% of the annual sales. Each EUV is equivalent to 1.137 billion yuan, which is a huge thing. A set of data often quoted by the media is that "a single device has more than 100,000 parts, and the hose is two kilometers long. Such a huge equipment weighs 180 tons, and a single shipment requires 40 containers, 20 trucks and 3 cargo planes."

3. Alibaba Cloud joins hands with Chinese Academy of Sciences

On January 26, the State Key Laboratory of Resources and Environmental Information Systems of the Chinese Academy of Sciences and Alibaba Cloud reached a cooperation to build an international leading "land surface system simulation and calculation platform", so as to conduct more in-depth research on the earth system and major geological disasters.

Through the "Terrestrial Surface System Simulation and Computing Platform", scientists can build spatial reconstruction models of geographic data fields, 3D dynamic process models of major geological disasters, Earth system science data sharing platforms, etc., to study the key causes of material and energy cycles in the system. Alibaba Cloud provides the State Key Laboratory with the Ali Feitian Cloud Computing Platform, which integrates high-performance computing, big data storage management, artificial intelligence and cloud computing service functions.

4. Chip supply chain organizations are calling on the new US government to review the ban on chip exports to China

In a January 25 letter to the U.S. Department of Commerce, SEMI, a semiconductor supply chain industry group that represents global semiconductor equipment manufacturers and equipment manufacturers, called on the new administration to review Trump’s August policy on Chinese chip export controls and urged the incoming U.S. Commerce Secretary to strengthen alliances with global competitive markets.

SEMI said in the letter that the previous administration’s approach to unilateral rules on chip exports was not effective, causing unnecessary harm to U.S. industries and vulnerable to retaliation by U.S. exporters.

The SEMI report also shows that China is rapidly developing its chip manufacturing capabilities. In 2012, China ranked only fifth in global IC wafer capacity, but it surpassed the United States and Japan in 2018 and 2019 to rank third, the organization said. SEMI called the trend "very noteworthy." SEMI statistics show that China’s IC wafer capacity has continued to grow since 2019, increasing by 14% in 2019 and 21% in 2020, and is expected to grow by at least 17% in 2021.

5, Kuaishou technology subscription first day hot, margin over-subscription up to 80 times the total amount of 85 billion Hong Kong dollars

Kuaishou technology on the first day of subscription yesterday, investors are enthusiastic about new. Data show that as of 17:26, the total amount of margin has reached 85.034 billion Hong Kong dollars, margin oversubscription has reached 80 times, of which tens of billions of margin scale brokers include: Phillip Securities Financing 31.50 billion, Futu Securities 16.247 billion, Huatai International 12 billion. It is expected that the oversubscription can reach 148.77 times. It is also said that the new page of the brokerage system was down yesterday.

6. MIIT responds to Lixun Precision’s investigation by US 337: Opposing bullying that suppresses normal business competition

On January 24, Apple’s leading supply chain company, Lixun Precision, disclosed the progress of the US International Trade Commission’s 337 investigation against the company, and said that the investigation will not have a material impact on the current production and operation. The investigation began on December 18, 2020, and was filed by Amphenol Corporation of the United States to the US International Trade Commission. The US Amphenol company, which has a partial competitive relationship with Lixun Precision, has experienced weak performance growth in recent years in the context of the market downturn. Gartner analysts said that "if the investigation finds that the company has indeed violated relevant laws, it will be sanctioned, and in addition to the risk of price increases, it may also face the risk of being unable to enter the United States."

MIIT responded to the matter on the afternoon of January 26, firmly protecting intellectual property rights, but also opposing abuse of rights and bullying that suppresses normal business competition.

7, the novel coronavirus real 3D images came out

For the first time, an international team, including Chinese researchers, has "captured" a 3D image of a novel coronavirus. On the nanoscale image, the novel coronavirus, with an average diameter of less than 100 nanometers, looks like a strange planet with freely swinging spike protein "tentacles" on its surface. Inside the "planet", ultra-long RNA chains are densely wrapped around an orderly arrangement of ribonucleoprotein complexes. On January 21, this novel coronavirus high definition popular science image was released by the team of Li Sai Laboratory of the School of Life Sciences of Tsinghua University and the Austrian Nanographics Company and Ivan Viola of King Abdullah University of Science and Technology in Saudi Arabia.

This achievement is also inseparable from the cooperation with Academician Li Lanjuan’s research group of the State Key Laboratory of Diagnosis and Treatment of Infectious Diseases in the First Affiliated Hospital of Zhejiang University School of Medicine. The collaborative research results were published in the online edition of the American journal Cell on September 15 last year. This is the scientific basis for the latest 3D virus science imaging.

Novel coronavirus real 3D image comes out

Digital Economy Dynamics

1. Geely Group’s low-orbit satellite Internet project was launched, with a total investment of 4.12 billion yuan

According to Qingdao Daily, Jiaozhou Natural Resources and Planning Bureau, Qingdao SCO Aerospace Science and Technology New Industry Project Planning Plan was announced before approval, marking the official launch of the project. The project belongs to Geely Satellite Internet Project with a total investment of 4.12 billion yuan and is located in the SCO Demonstration Zone. The total land area of the project is 20,474.3 square meters.

According to the relevant person in charge of the SCO Demonstration Zone Management Committee, in early August last year, the SCO Demonstration Zone Management Committee and Geely Technology Group signed a cooperation agreement on low-orbit satellite Internet projects. According to the cooperation agreement, the SCO Demonstration Zone and Geely Technology Group will lay out and build satellite Internet-related businesses in the SCO Demonstration Zone, with the aim of building a world-leading Internet of Things demonstration project. The project is undertaken by Geely’s subsidiary Zhejiang Time and Space Daoyu Technology Co., Ltd.

2. China Mobile and China Radio and Television have signed a 5G co-construction and sharing cooperation agreement

China Mobile announced in the Hong Kong Stock Exchange that China Mobile Communications, a wholly-owned subsidiary of the company, entered into a specific cooperation agreement on 5G co-construction and sharing with China Radio and Television on behalf of its 31 provincial companies. The two sides jointly built a 700 MHz wireless network, and China Mobile Communications paid China Radio and Television to share a 2.6 GHz network.

3. Panasonic EP smart home appliance project settled in Qiantang New District

On January 21, a signing ceremony was held for the EP smart home appliance project of Hangzhou Panasonic Home Appliances (Comprehensive Bonded Zone) Co., Ltd.

The total investment of the project is 300 million yuan, the land is more than 30 mu, and the construction area is about 30,000 square meters. It is planned to be put into use in April 2022. After reaching the post-production period, the production capacity will gradually reach 1.80 billion yuan.

4, our country 5G + industrial Internet projects have exceeded 1100

On January 26, the State Council Information Office held a press conference on the development of industry and informatization in 2020. Zhao Zhiguo, spokesperson of the Ministry of Industry and Information Technology and director of the Information and Communications Administration, pointed out in response to the key work of 5G development proposed by reporters that it is necessary to do a good job in three aspects, and promote 5G to better empower thousands of industries and show a variety of situations. In accordance with the principle of appropriate advance, continue to deepen the deployment of 5G network construction.

In 2020, more than 600,000 new 5G base stations were built, the number of 5G end point connections exceeded 200 million, and there were more than 1,100 5G + industrial Internet projects.

Zhao Zhiguo pointed out that in 2020, the Ministry of Industry and Information Technology will work with relevant departments and coordinate all parties in the industry to continuously improve policies and measures, continue to increase investment, and our country’s 5G commercial development should be said to have taken a solid step. In 2020, more than 600,000 new 5G base stations will be built, achieving full coverage of 5G networks in all cities above the prefecture level; the number of 5G end point connections will break through 200 million, and many industries will seize the major opportunities brought by 5G commercial use to accelerate the process of industrial digitalization; 5G + industrial Internet projects have exceeded 1,100, 5G + remote consultation has been launched in more than 60 hospitals in 19 provinces, and new models and new formats such as 5G + autonomous driving, 5G + smart grid, and 5G + distance education are constantly emerging. Overall, 5G empowers entities, benefits society, and serves the people, and is increasingly becoming an important driving force for high-quality economic development.

5. Anheng Information was shortlisted for the 2020 "Zhejiang Made Boutique" list

Recently, the list of "Zhejiang Manufacturing Excellence" in 2020 was released. After enterprise declaration, recommendation by local economic and information departments and industry associations, expert review and publicity, 263 products were determined to be "Zhejiang Manufacturing Excellence" in 2020. Among them, Anheng Information became one of the representatives of Zhejiang Manufacturing Excellence. The selected products this time are "Internet of Things Security Heart/DAS-IOT-SH". After declaration and rigorous review by experts, they were successfully shortlisted and were rated as "Zhejiang Manufacturing Excellence" in 2020. "

Digital Economy Policy

1. [Xiaoshan District] Notice on Launching the 2019 Collection of "Unicorn" and "Quasi-Unicorn" Policy Support Projects in Xiaoshan District

Project solicitation requirements

1. The declared enterprise must be registered in Xiaoshan District for industry and commerce and taxation, have independent legal personality, and have a sound financial management system. The enterprise must be included in the "2019 Xiaoshan District" Unicorn "and" Quasi-Unicorn "plans.

2. The relevant R & D investment projects declared need to set up detailed subjects and special project accounting.

3. The project applicant must be the specific organization and implementation unit of the project, and has not received relevant financial assistance at the district level.

4. The application materials must be true and reliable, without fraud.

II. Project application procedures

1. Declaration time. January 21-February 10, 2021

2. Application basis and requirements. In accordance with the relevant requirements of the "Declaration Instructions for" Unicorn "and" Quasi-Unicorn "Policy Support Projects in Xiaoshan District" and other attachments, the corresponding application materials are objectively and truthfully prepared (see the attachment for details).

3. Format for submission of application materials. In accordance with the requirements of the "Declaration Content Explanation for" Unicorn "and" Quasi-Unicorn "Policy Support Projects in Xiaoshan District", the materials are bound into a book, and the binding materials are bound in paper and two copies, and one electronic version.

4. Place of submission of application materials: 703, Block C, Water Building.

III. Declaration contact information

District Economic and Information Bureau Contact: Gao Jiecan, Ye Huimin 82705239 82705238; Email: 1042430841@qq.com (electronic materials are sent to this email)

District Finance Bureau Contact: Zheng Chao 82753986

Attachment download address: https://share.weiyun.com/Vjy9UnuY

This project will be closed on February 10, 2021.

Source: West Lake District

2. [Yuhang District] Notice on Organizing the Application of the First Batch of Enterprise Cultivation Financial Support Policies in Yuhang District in 2020

First, the application object

Large enterprises and large groups during the cultivation period from 2016 to 2020.

II. Policy enjoyment

1. If large enterprises and large groups cultivate enterprises that meet the policy conditions, they will be given incentives and subsidies through project support. 80% of the local fiscal contribution of paid taxes in 2019 exceeds the base.

2. If the enterprise cultivation object adds new industrial land during the cultivation period, the tax base will be increased by 200,000 yuan per mu from the next year after the project is put into operation. For the industrial land obtained by the cultivation enterprise through bidding and auction, the project that has not been put into production after 5 years from the year of land acquisition will be regarded as put into production, and the tax base will be increased by 200,000 yuan per mu of actual tax from the 6th year (from the first year of land acquisition). At the same time, for enterprises that withdraw from industrial land due to the closure or relocation of urbanization, energy conservation and emission reduction, etc. (except for long-term idle withdrawal), the tax base will be reduced by 200,000 yuan per mu of actual tax from the year of withdrawal from industrial land. The specific increase (decrease) of the local retained part of the paid tax base is based on 200,000 yuan per mu as the standard, and the local retained tax base of the increase (decrease) is determined according to the calculation of the tax structure of the actual tax paid by the enterprise in the current year.

3. Local fiscal contribution = the local retained part of the tax paid by the enterprise – the total amount of financial funds that have been subsidized (50% deduction for enterprises that receive competitive allocation funds).

4. The taxes involved in financial incentives are: value-added tax, enterprise income tax. The caliber of tax redemption is: first, value-added tax, calculated according to the actual value-added tax paid in the corresponding period × 40% + the value-added tax exempted in the corresponding period × 40%; second, enterprise income tax, calculated according to the annual settlement and payment of the corresponding period × 32%.

III. Declaration requirements

1. Materials required for enterprise declaration:

(1) Table of Contents (indicate page number)

(2) Application Form for Tax Support Policies (see Annex 1)

(3) Project declaration commitment letter (see Annex 2)

(4) Annual financial statements (balance sheet, income statement)

(5) Copy of business license

(6) Merger and Cultivation of Subsidiaries (see Annex 3)

(7) List of new industrial land use by enterprises (see Annex 4)

(8) Other relevant supporting materials

2. The application situation of the enterprise must be true and reliable, and no fraud shall be allowed; the application materials shall be reported in 2 copies to the "Pro-Qing Online" Service Center of Yuhang District, Hangzhou (the first floor of the District Finance Bureau); the electronic version shall be submitted to the wujun7229@dingtalk.com synchronously. The application time ends on February 8, 2021, and overdue will not be accepted.

Contact: Li Liangyi and Wu Jun, Economic Operation Section, District Economic and Information Bureau, Tel: 86223024, 89089835; Wang Zhonghong and Xu Zhen, Enterprise and Finance Section, District Finance Bureau, Tel: 86232756, 86130033.

Attachment download address: https://share.weiyun.com/6dPaXPky

The application for this project will be closed on February 8, 2021.

Source: Yuhang District

Digital Economy Financing List

1, Didi freight will complete the first round of financing of 1.50 billion US dollars

On January 26, it was reported that Didi Freight has completed the first round of financing agreement of 1.50 billion US dollars. The lead investors are Temasek Holdings, CPE Yuanfeng (CITIC Industry Fund), IDG Capital, etc. Other participants include Zhongguancun Nongmen Fund, Private Equity Agency of Prologis, Hidden Mountain Capital, Country Garden Venture Capital, VMS Group and Yunfeng Fund, etc. This round of financing is planned to be completed in February this year. The main company of Didi Freight is Beijing Kuaiju Anyun Technology Co., Ltd., which was established in April 2020. The legal representative is Zhao Hui. Its business contents include: operating telecommunications business; technical development of computer software, technical consultation, technical services, etc.

2. Self-driving company "Yishi Technology" received over 1 billion yuan in financing

UISEE, an autonomous driving company, announced the completion of a new round of financing with a total of over 1 billion yuan, including strategic capital injections from multiple industrial investors and the CDB Manufacturing Transformation and Upgrading Fund. This is the first investment of the CDB Manufacturing Transformation and Upgrading Fund in the field of autonomous driving. This round of financing will be used to strengthen the research and development of key technologies for the "all-scene, truly unmanned, all-weather" autonomous driving platform, and work with the industry to promote the large-scale commercialization of autonomous driving.

3, Spark thinking completed the E round of over 400 million US dollars financing

On January 25th, Spark Thinking, an online education brand for children, announced the completion of the E3 round of financing. This round of financing was led by Trustbridge, followed by old shareholders such as Tencent, and Light Source Capital continued to serve as the exclusive financial advisor. So far, Spark Thinking has completed all three rounds of financing in the E round within 5 months, with a total financing of more than 400 million US dollars.

THE END

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Original title: "Digital Economy Release | Provincial Government Report: Implementation of Digital Economy" No. 1 Project "2.0; Geely 4.12 billion Yuan Low-Earth Orbit Satellite Internet Project Launched; Anheng Shortlisted for 20 Years of Zhejiang Manufacturing Excellence List"

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July has been a difficult month for Wang Jianlin. In the past month, Wang Jianlin and Wanda have frequently become the focus of public opinion due to a series of fire sale operations. Although the title of richest man has long been lost, the exposure has not diminished at all.

Wang Jianlin, chairperson of Wanda Group, sold his assets three times in a row under financial pressure, recovering a total of nearly 7 billion yuan. These assets include Wanda Film and Beijing Wanda Investment, and the transfer price is lower than the market price.

Wang Jianlin has sold assets three times in a row:

On July 10, Wanda Investment and Ms. Lu Lili signed the "Share Transfer Agreement". Wanda Investment transferred its shares of Wanda Film 180 million to Lu Lili, accounting for 8.26% of the company’s total share capital. The transfer price was 12.07 yuan/share, involving an amount of 2.173 billion yuan.

On July 17, Wanda Investment and its concerted action Shanxian Rongzhi signed the "Share Transfer Agreement", Wanda Investment transferred its holding of Wanda Film 177 million shares to Shanxian Rongzhi, accounting for 8.14% of the company’s total share capital, and the transfer price was 13.17 yuan/share, involving an amount of 2.331 billion yuan.

On July 23, China Ruyi announced that Shanghai Ruyi, a wholly-owned subsidiary of the company, acquired 49% of the shares of Beijing Wanda Investment Co., Ltd. (referred to as "Wanda Cultural Industry Group") held by Beijing Wanda Cultural Industry Group Co., Ltd. (referred to as "Wanda Investment") at a transaction price of 2.26 billion yuan.

After the transfer, Wanda Investment will be held 49.8% by Wanda Cultural Industry Group, 49% by Shanghai Ruyi, and 1.2% by Wang Jianlin. Wanda Investment is the controlling shareholder of listed platform Wanda Film, holding 20% of its shares. After the change of rights and interests is completed, Shanghai Ruyi indirectly holds a 9.8% stake in Wanda Film through Wanda Investment.

Transferring assets can only ease Wanda’s current cash flow problems. S & P pointed out that Wanda Commercial will face huge repayment pressure in the next 12 months.

According to public information, the current Wanda commercial management of 11 surviving bonds, the scale of 10.766 billion yuan, of which the scale of maturity within one year is 1.348 billion yuan. In terms of US dollar bonds, the current Wanda commercial management of 4 US dollar bonds, the scale of survival 1.70 billion US dollars, two of which total 1 billion US dollar bonds will mature within one year.

Industry insiders believe that the biggest risk for Wanda at present is whether it can go public. If Zhuhai Wanda Commercial Management cannot go public by December this year, according to the gambling agreement, Wanda will not only have to redeem 38 billion yuan, but also pay 12% interest. "

At present, China Chengxin International, Fitch, Moody’s and S & P have successively adjusted the rating of the joint stock company of Dalian Wanda Commercial Management Group.

In response, Wanda Commercial Management Group responded that the company’s operations are stable and its profitability is good. The company will strictly abide by the provisions and requirements of relevant laws and regulations, earnestly fulfill its information disclosure obligations, and remind investors of relevant risks on relevant matters.

[One and one new car listed] On March 12th, the global version of the Great Wall Gun (parameter picture) passenger pickup truck was officially listed. The global version of the Great Wall gun pickup truck listed this time has a total of eight configurations. As a "Chinese high-end pickup truck" that Great Wall is committed to building, the global version of the Great Wall gun pickup truck has been fully armed with ultra-new concepts and ultra-high standards.

The global version of the pickup truck for the Great Wall Artillery is 5410*1934*1886(mm), the container size is 1520*1520*540(mm) and the wheelbase is 3230mm. Although the size is slightly smaller than other models, the container size and wheelbase are still the best in the same class. Not only does it perform well in size, but the global version of the Great Wall gun pickup truck also has 18-inch aluminum alloy wheels, and the visual effect is amazing. There are eight kinds of vehicle color matching options, and there are three kinds of shapes of rain shelter that can be customized, which can meet diversified car scenes and needs while pursuing individuality.

In terms of appearance, compared with the cash, the global version of the pickup truck for the Great Wall gun has only changed the middle net, logo and the lower trim panel of the front bumper, turning the style of the middle net into a wide horizontal bar with a more international style and strength, and at the same time, the logo has been further increased, highlighting domineering and increasing the sense of fashion. Headlights use high-brightness LED lights, and the Hawkeye Smart Headlights Group does not lack the configuration that all smart headlights should have. The only standard advanced privacy glass in the same class that can filter 98% ultraviolet rays also shows high-end. This is also an important step for the Great Wall to create a high-end pickup truck style in China.

The interior parts have changed greatly. While maintaining the same color matching of all black/black brown interiors as the current ones, the central control panel, dashboard trim panel, sub-dashboard central control panel, seat texture and door trim panel of the global version of the pickup truck for the Great Wall Gun have all been upgraded in luxury and grade.

Of course, on the one hand, this upgrade is to increase practicality and comfort, on the other hand, it is also to continuously enhance the freshness of the market and enhance the product strength to maintain the leading edge. However, the interior of the global version of the pickup truck for the Great Wall Gun is indeed more advanced than the cash.

By the way, the global version of the pickup truck for the Great Wall cannon adopts deep-sea mute, and optimizes the wind resistance, which is quieter and quieter. The 808*402(mm) Webasto high-quality skylight equipped with the global version of the pickup truck for the Great Wall Gun has an area of 0.32 square meters, which is not only unique in the same class, but also the first match of pickup truck models, and also supports one-button opening.

In terms of other configurations, the global version of the pickup truck for the Great Wall cannon provides flat-cover canopy, high-cover canopy and roof rack for consumers to choose from, and the car also adopts a brand-new UI interface, which enhances the sense of interaction. The seat also adds front and rear seat heating and front seat ventilation, which is more friendly to passengers. The rear elbow pillow, cup holder, wireless charging and electric side pedal also improve the quality from the details, which is both face-saving and more comfortable.

In terms of power, the global version of the pickup truck for the Great Wall Gun provides two engines to choose from. One is a 2.0T diesel engine with a maximum power of 120kW and a maximum torque of 400N·m, and the other is a 2.0T gasoline engine with a maximum power of 140kW and a maximum torque of 360N·m, both of which match the ZF 8AT gearbox. And there are three modes to choose from: economy, standard and sport, plus the two-speed TOD intelligent four-wheel drive system, which can easily cope with various road conditions and still have good fuel consumption performance.

In addition, the global version of the pickup truck for the Great Wall Artillery uses a non-load-bearing body and a five-link rear suspension, which is not only comfortable but also more stable. It is also blessed by the Eaton differential lock, which greatly enhances the confidence of driving in the field. Approach angle of 29.8 degrees, departure angle of 25 degrees, wading depth of 500mm, even if the off-road capability is inferior to that of professional off-road vehicles, at least you can ignore the gullies and ridges of most wild forests.

Not only the hardware, but also the global version of the pickup truck for the Great Wall Gun is equipped with L2-class automatic driving and 360-degree look around. The body adopts a high-strength cage body and is equipped with 6 airbags. The intelligent field is equipped with active and passive safety functions such as AEB, ACC, TSR, LCA, DOW, etc., and with many intelligent driving AIDS, it is definitely an advanced pickup truck from hardware to technology to teeth.

Summary:

From the perspective of global pickup trucks, the Global Edition of the Great Wall Artillery Pickup Truck is committed to building Chinese high-end pickup trucks, which are in line with the world-famous global pickup truck models such as Ford F150, Toyota Smooth Road and Dodge RAM, and incorporate the characteristics of China with high configuration and low price. Not only in terms of functional control, loading and passability, but also the driving experience has reached or even surpassed some SUV models. Such a pickup truck model that is full of personality and more inclined to ride experience will certainly be welcomed by consumers. At the same time, it is hoped that domestic pickup trucks will rank among the first-class pickup trucks in the world, so that the whole world can drive high-profile pickup trucks in the East.

The reserved interface of Han series vehicles is in the black shell at the front. The ETC reserved interface can be used for installing driving recorder or ETC equipment. Most people may not know where the reserved interface is. Please share the installation steps and effects of Kailude C1 driving recorder. Just plug in the ETC interface of the original vehicle. This is a two-in-one interface, which does not affect the installation of ETC. Attach a location map.

The installation steps are simple, and the most important thing is to find the reserved interface. Using the crowbar tool, the back shell can be well removed. First, pry the small middle cover from top to bottom and take it down by hand, and then directly take down the pried gaps on the left and right sides of the big shell, so that the reserved interface position can be directly seen.

Kailude C1 driving recorder, the mold corresponding to the vehicle model, and the original one-in-two ETC power plug, crowbar tools, etc.

The model can watch videos on the mobile APP, and the video can also be watched on the big screen of the car. The recorder comes with a wifi mold, and the mobile phone and the car are connected to view without traffic.

foreword

Malignant multiple myeloma(multiple myeloma ； MM) is a kind ofwithMalignant disease characterized by massive proliferation of monoclonal plasma cells in bone marrow. B cell maturation antigen (BCMA) is highly expressed on the surface of MM cells. In the past few years, great progress has been made in various BCMA targeted immunotherapy for recurrent/refractory MM patients, including anti-BCMA monoclonal antibodies, antibody-drug conjugates (ADC), bispecific T cell binders (BITE) and chimeric antigen receptor adoptive T cell therapy (CAR-T). The 63rd annual meeting of American Hematology Society updated some information about the application of BCMA in MM, and based on this annual meeting, the related contents of this paper were sorted out [1].

Immunotherapy targeting BCMA: (1)ADC; 　 (2)CAR-T; 　 (3)BiTE;　

copywriter |　NING

BCell maturation antigen (BCMA)

Also known as TNFRSF17, it is a member of TNF-receptor family, and is called tumor necrosis factor receptor superfamily 17. This receptor is expressed on the surface of B lymphocytes and plasma cells, and is a marker protein of B lymphocyte maturation. Under physiological conditions, BCMA is mainly expressed in plasma mother cells and terminally differentiated plasma cells (PC). Under pathological conditions,BCMA Almost in all MM Tumor cell line (80%–100%) are expressed.The number of BCMA on the surface of malignant PC is much higher than that of conventional PC, which explains why BCMA target has become a battleground for major biological enterprises.

Monoclonal antibody targeting BCMA

SEA-BCMAIt is a new humanized non-fucosylation. IgG1 mAb. The working mechanism of SEA-BCMA may include blocking BCMA activation and its downstream proliferation signal pathway, regulating antibody-dependent cell phagocytosis and enhancing antibody-dependent cytotoxicity.

Its clinical phase I trial (SGNBCMA-001; The preliminary results of NCT03582033) show that it has good safety and combination potential: SEA-BCMA also shows encouraging treatment duration and initial anti-tumor activity in the advanced R/R MM population who have received a lot of treatment before.

Source: blood (2021) 138 (Supplement1): 2740.doi: 10.1182/blood-2021-146047.

Bispecific T Cell cement (BITE)

BiTEs can simultaneously target BCMA on MM tumor cells and CD3ε domain of TCR on T cells. After T cells are combined with myeloma cells, cytotoxic T cells can be activated and secrete cytotoxic factors, thus producing cell killing effect.This part is still in Ⅰ at present./Phase ii.

The following table summarizes the clinical data of bispecific antibodies against BCMA, among which the BiTE bispecific type of BCMA×CD3 is the most common.

Novel trispecific antibody drugs

Researchers are no longer satisfied with treating patients with R/R MM through dual-target therapy.HPN217, an extended half-life (median serum half-life:74 Hours) three specificity. T Cell activation construct (TriTAC)It simultaneously targets BCMA and CD3ε (redirected T cells), and adds serum albumin to prolong the half-life, which can exert cytotoxic effect on myeloma cells.Currently working onR/R MM of 1 /2 Phase I clinical trial for evaluation (NCT04184050). Here are some preclinical data.

Legend: HPN217 mediates the killing effect of autologous T cells of NCG mice on BCMA-dependent/primary MM cells.

Source: blood (2021) 138 (Supplement1): 1185.doi: 10.1182/blood-2021-151880.

CDR101(CDR-lifeCompany’s products)Is simultaneous targeting.CD3、BCMAandPD-L1The trispecific antibody,T cells can be induced into tumor cells expressing BCMA, and the immunosuppressive effect caused by the interaction between PD-L1 and PD-1 can be blocked at the immune synaptic site. Compared with BCMA × CD3 bispecific drugs, CDR101 leads to at least a tenfold increase in T cell-mediated tumor cell lysis, and performs better than the combination of PD-L1 inhibitor and BCMA × CD3 bispecific drugs.CDR101 It may become a new ready-made treatment, providing a more lasting response and a higher cure rate. CDR101 Has excellent drug-like characteristics, high stability and high stability.CHOHigh yield of expression.Based on these findings, new trispecific immunotherapy drugs have high clinical potential and promising clinical application [2].

Antibody drug conjugate (ADC)

After recognizing BCMA on the cell surface, ADC internalizes it into myeloma cells. Through the degradation of lysosomes or endosomes, the payload is released, causing cytotoxicity.

Belantamab mafodotin (GSK2857916)Is targeted by humanization.BCMA IgG1 andMMAF(tubulin polymerization inhibitor). Belantamab mafodotin was approved by the US Food and Drug Administration (FDA) in 2020 to treat patients with R/R MM.This is the first target approved for listing.BCMAimmunotherapy,A multicenter phase II clinical study (NCT03525678) confirmed that the recommended regimen for patients was 2.5 mg/kg, once every three weeks, but the toxicity of the drug was mainly manifested in thrombocytopenia and pericorneal lesions, such as microcystic epithelial changes or superficial punctate keratopathy. In addition to belantamab mafodotin, several other ADCs targeting BCMA, such as AMG 224, MEDI2228 and HDP-101, have also conducted many preclinical or clinical studies at different stages.

Legend: Incidence rate of adverse events caused by Belantamab mafodotin at 2.5 mg/kg and Q3W.

Antibody drug conjugate (ADC) joint test.

In the joint experiment, there are two schemes: belantamab+DEX (dexamethasone) and belantamab+DEX+POM.

belantamab(2.5 mg/kg Q3W) and DEX(20-40 mg Q1W,threeCycle) jointAfter use, the objective remission rate (ORR) was 46%, the complete remission rate (CR) was 14%, the median progression-free survival (PFS) was 4.9 months, and the median overall survival (OS) was 7.4 months. The incidence of AEs from high to low is anemia (83%), keratopathy (82%; Gr3/4: 56%), thrombocytopenia (70%) and so on.

belantamab+DEX+POMUnion ofIn the experimental scheme, the ORR was 88.9%(48/54), and the CR and PR rates were 24.1%(13/54) and 20.4%( 11/54) respectively. However, keratopathy (96.9%) was also the most common AE, and 56.7% of such patients had reached Gr 3/4. These two studies show that POM and DEX may have a positive effect on the curative effect of belantamab. howeverKeratosis is still a challenge in the treatment process.

Legend: Detailed rules and results of belantamab+DEX (Dexamethasone) joint trial scheme.

Source: Blood 2021; 138 (Supplement 1): 1642. doi: https://doi.org/10.1182/blood-2021-149791

CAR-Ttherapy

nowTwo CAR-T therapies based on BCMA have been approved for marketing.And is used for treating patients with multiple myeloma.

Source: "CAR-T therapy targeting BCMA"

7.1

Cilta-cel (Carvykti) for Orense injection.

Sidaki Orense injection(Cilta-cel,Carvykti) yes2022year2moon28Listed in China (NMPAApproved for listing/FDAFormal approval) targeting.BCMAofCAR-TCell products, jointly developed by Janssen and Legendary Bio, Legendary Bio owns 70% interests in Carvykti Greater China and 50% interests overseas.

In CARTITUDE-1 trial, the overall remission rate was 97%, the 18-month progression-free survival rate was 66%, and the 2-year progression-free survival rate was 61%. The 18-month overall survival rate is 81%, and the 2-year overall survival rate is 74%. Compared with similar products, this data is very gratifying. According to the latest news from Kingsley, the sales of the legendary BCMA CAR-T new drug Carvykti in the first half of the year was 24 million US dollars.

7.2

Abecma（Ide-cel）

2021yearthreemoon26Day,FDAapproveBaishimei SquibbAbecma(Ide-cel)be listedAbecma is also a BCMA-oriented CAR-T cell therapy, which is customized from patients’ autologous T cells. Clinical data show that the overall remission rate of all patients is 72%, of which the complete remission rate is 28%; Even for patients who have received various regimens, the remission rate of Abecma still reaches 72%, and this remission is very lasting, and 65% of patients are over 12 months.

Legend: preparation principle of Abecma

7.3

Iqalunsei injection

In addition, June 2, 2022Reindeer biology/Xinda biologyAnnounce BCMA CAR-T therapyIqalunsei injectionThe listing application was obtained.NMPAAccepted, it is expected to become the first domestic independent research and development of the whole process.CAR-Ttherapy. The clinical research data reported at the 63rd ASH annual meeting in 2021 showed that the overall remission rate (ORR) was 94.9%, and the complete remission rate/strict complete remission rate (CR/sCR) was 58.2%, showing the excellent safety and effectiveness of Iqalunsei injection.

Source: NMPA official website

7.4

The clinical trial of CAR-T therapy targeting BCMA is as follows

summary

Judging from the listing situation,Belantamab mafodotin (GSK2857916) is composed of humanized targeting BCMA IgG1 and MMAF (tubulin polymerization inhibitor), which is the first targeted BCMA immunotherapy approved for marketing. At present, there are two CAR-T therapies that have been put on the market, developed by Bristol-Myers Squibb respectively.Abecma(Ide-cel), developed in cooperation with Janssen)/ Legendary Biology.Sidaki Orense injectionFrom the data point of view, the latter effect is better, the ORR is increased from 72% to 97%, and other indicators are relatively better. On June 2nd, 2022, Reindeer Bio/Cinda Bio announced BCMA CAR-T therapy.Application for marketing of Iqalunsei injectionIt has also been accepted by NMPA, and it is expected to become the first CAR-T therapy independently developed in the whole process in China. Let us wait and see! From the therapeutic point of view, CAR-T therapy is at the forefront in terms of clinical data and market situation, but we can’t simply judge the advantages and disadvantages of these products. For example, better anti-BCMA CAR-T cell therapy requires more complicated preparation conditions and more expensive treatment costs, which are unbearable for ordinary families. Therefore, while continuing the existing research, it is necessary to study the potential mechanism affecting the curative effect in order to optimize BCMA targeted immunotherapy.

　 　

Legend: Comparison of clinical efficacy between different immunotherapy products targeting BCMA (see [1] for specific clinical data).

reference data

[1]Targeting BCMA to Treat Multiple Myeloma: Updates From the 2021 ASH Annual Meeting. Front Immunol. 2022 Mar 7; 13:839097. doi: 10.3389/fimmu.2022.839097. PMID: 35320942; PMCID: PMC8936073.

[2] Blood 2021; 138 (Supplement 1): 1583. doi: https://doi.org/10.1182/blood-2021-152160

[3] Blood 2021; 138 (Supplement 1): 1642. doi: https://doi.org/10.1182/blood-2021-149791

* Tweets are used to transfer knowledge. If you have any questions about copyright, please contact BiG Bio-innovation Society within 30 days after the publication of this article.

　　Huawei usually releases new P-series machines in the spring, and it’s the P70 series this year. According to mobile phone China, Huawei P70 series has a lot of news on the Internet, but not much about the price. Some digital bloggers recently broke the news that the price of Huawei P70 series may be similar to that of Mate60 series.

　　Huawei P70 series imaginary map

　　Recently, a blogger wrote that what is the price of Huawei P70 series? Refer to the Mate60 series, which is not bad. In the comment area, some netizens suspected of pollen said that the P70 series would be cheaper than the Mate60 series, while bloggers replied that it was "not much cheaper", which seemed to confirm the speculation that the P70 series was relatively cheaper. In addition, some netizens asked whether Huawei P70 series will continue the color scheme of Rococo White, while bloggers said that P70 series has white, but it is not necessarily Rococo White.

　　Let’s review the price of Huawei Mate60 series:

　　Huawei Mate 60-12 GB+256 GB 5499 yuan; 12gb+512gb5,999 yuan; 12GB+1TB 6999 yuan

　　Huawei Mate 60 Pro-12 GB+256 GB 6499 yuan; 12GB+512GB 6999 yuan; 12GB+1TB 7999 yuan

　　Huawei Mate 60 Pro+-16GB+512GB 8999 yuan; 16GB+1TB 9999 yuan

　　Huawei Mate 60 RS extraordinary master-16GB+512GB 11999 yuan; 16GB+1TB 12999 yuan

　　According to the blogger’s news, the starting price of Huawei P70 series should be less than 5499 yuan. In addition, the starting price of Huawei P60 series is 4488 yuan, so the starting price of P70 series can be expected.

Major listed companies in the video surveillance equipment industry:At present, there are mainly listed companies in the domestic video surveillance equipment industry (002415); (002236); (002214); (300449); (300150); Dongfang Netpower (300367); (300155); (002835); (300101)。

Core data of this article:China video surveillance equipment industrial chain, China video surveillance equipment panorama, China video surveillance equipment industrial chain enterprise output.

1. Panoramic combing of the industrial chain of video surveillance equipment industry: video surveillance equipment is recycled into an important link.

The upstream of the industrial chain of video surveillance equipment includes components, algorithms and processor chips, among which components mainly include sensor chips, optical lenses and memories. The algorithm mainly includes image processing, video compression and content recognition. The processor chip mainly includes ISP chip in analog camera, SoC chip in network camera, SoC chip in DVR/NVR and deep learning algorithm accelerator chip.

Midstream equipment products mainly include front-end cameras (divided into analog cameras and network cameras), back-end storage and video recording equipment (divided into DVR, NVR, CVR, etc.), control and display equipment at the central control end (including display screen, server and control keyboard, etc.) and optical terminals and switches in each transmission link. In addition, there are system management software based on hardware products.

The downstream products have a wide range of terminal applications, which can be divided into city-level, industry-level and consumer-level end-user applications.

At present, in the field of upstream components of video surveillance equipment, the main representative companies are Hehe, Huawei Hisilicon and ZTE Microelectronics in the field of processor chips, and contempt technology and Shangtang technology in the field of algorithms. In the middle reaches of video surveillance equipment, Hikvision and Dahua Co., Ltd. have layouts in front-end, back-end, control terminal and other hardware fields, software and integration. There are many industries and enterprises involved in the downstream of the video surveillance equipment industry chain, and the representative enterprises are,, and so on.

2. The regional thermal map of China video surveillance equipment industry chain: Shanghai is the most concentrated.

Due to the low technical content and low entry threshold of low-end video surveillance equipment, there are many video surveillance enterprises in China, but the scale is generally small. According to the data of Qicha Cat, China’s video surveillance equipment related enterprises are mainly distributed in Shanghai, Guangdong, Jiangsu, Fujian and other regions, with the distribution characteristics of "western light and eastern heavy". Among them, Shanghai has the most concentrated distribution of related enterprises. As of August 2021, Shanghai has more than 40,000 enterprises, followed by Guangdong with more than 30,000 related enterprises.

From the distribution of representative enterprises, there are many representative enterprises in Beijing, Shanghai, Guangdong and Zhejiang, among which Hikvision and Dahua, the leading video surveillance enterprises in China, are located in Zhejiang.

3. Capacity/output of representative enterprises in China video surveillance equipment industry: Hikvision’s output is far ahead of other enterprises.

At present, among the listed companies with chips related to frequency monitoring equipment, the output of integrated circuit series products is more than that of other companies, and the output of Hikvision is far ahead of other companies in video monitoring listed companies. The capacity/output of other representative enterprises in the industrial chain of video surveillance equipment industry is as follows:

Note: The enterprises in the statistics are listed companies that have published relevant capacity/output data, and listed companies that have not published specific capacity/output data are not included in the statistics.

4. Latest investment trends of representative enterprises in China video surveillance equipment industry.

Since 2020, the investment trends of representative enterprises in the video surveillance equipment industry mainly include acquiring companies to expand their business and investing in video surveillance equipment production base projects by increasing capital of subsidiaries. The latest investment trends of representative enterprises in the video surveillance equipment industry are as follows:

Please refer to Foresight Industry Research Institute for the above data and analysis. At the same time, Foresight Industry Research Institute also provides solutions such as industrial big data, industrial research, industrial chain consultation, industrial map, industrial planning, park planning, industrial investment attraction, IPO fundraising feasibility study, IPO business and technology writing, and IPO working paper consultation.

headline

Chinese youth killed by police: video release is justified!

[Comprehensive News]Christian Hall (Chinese name: Chen Zhibo), a 19-year-old Chinese youth in Pennsylvania, was shot and killed by state police in December last year. At present, it has been ruled as a legitimate reason (legal) by DA in Monroe County, Pennsylvania.

On December 30th, someone called 911 anonymously, and the anonymous caller was Hall himself. The police rushed to the scene on I-80 and found Hall standing on top of the concrete safety barrier. After some continuous twists and turns, Hall then took the gun (an air gun like a pistol) from his waist and took a step towards the police. Then a police officer fired several shots, but missed Hall.

You can see that Hall raised his arm to the side, turned the weapon to the side, and turned the barrel to aim at his head. At this time, it was the critical moment when the police decided to shoot him.

The police said: "Because Hall’s behavior caused a potential threat of death or injury, in this case, it is legal for Pennsylvania police to use deadly force against Hall."

The Monroe County District Attorney said they didn’t think the police were at fault, and they wanted to make sure Hall’s family didn’t blame themselves for it. The prosecution said that Pennsylvania law does not require suspects to fire at the police. Hall (Chen Zhibo) used an air gun to force the police to shoot, which is a common "suicide by cop" behavior.

Spot News

1. There are dozens of mysterious brain diseases in North America, with 5 deaths and 43 hallucinations!

[Guardian]New Brunswick, Canada, has recently been exposed to investigating dozens of mysterious brain diseases. However, the news was first exposed by the outflow of internal government documents, and the health department refused to provide more details. It is reported that there have been 43 cases of such brain diseases in this province, and the cause of the disease has not yet been identified. Specific symptoms include memory shortage, vision problems, abnormal convulsions and so on.

According to the report, in 2015, the first suspected case appeared in the local area, and in 2019 and 2020, there were 11 cases and 24 cases respectively, and a total of 5 people died. However, it was not until last week that local residents learned the news from the internal memo of the health department obtained by the media. Health officials still refuse to disclose the specific location of the cases, but some experts say that the number of cases is small and there are still many problems to be studied, so the public should not panic.

2. Pfizer —BioNTech: The vaccine is 100% effective for teenagers aged 12-15.

【CNBC】Pfizer and BioNTech announced in a joint press release on Wednesday that Pfizer -BioNTech Covid-19 vaccine is safe and effective in adolescents over 12 years old. The vaccine can prevent symptomatic diseases 100% effectively in the experiment, and trigger a stronger immune response among teenagers than adults. They hope to start vaccination for American teenagers before the next school year.

Pfizer and BioNTech of Germany said that the vaccine trial data of nearly 2,300 teenagers aged between 12 and 15 will be submitted to the US Food and Drug Administration (FDA) in the next few weeks. At present, Pfizer -BioNTech vaccine has been approved by FDA and can be used urgently for people over 16 years old.

3, solved the case! The US Strategic Command tweeted garbled for Xiong Haizi.

[Fox News Network]On March 28, local time, the US Strategic Command Twitter sent a strange message, the original text was "; l; ; gmlxzssaw,”。 This tweet quickly triggered various speculations on the Internet. Some people suspected that the headquarters had inadvertently sent out the nuclear weapon launch code; Some people joked that this message was for aliens; Others "reasonably declined" that there was a cat stepping on the keyboard and "unintentionally" knocking down this line of words.

The US Strategic Command replied: At that time, the Twitter manager of the command was working remotely. Just when he left the computer for a short time and was still logged in to the Twitter account, his young children knocked down these characters and did not intend to send a tweet. In the end, the tweet was deleted, and before it was deleted, it had received 11,000 replies.

4. New York State Legislature Passes Marijuana Legalization Bill Governor: A Big Step.

【CNN】On the evening of the 30th local time, the Senate and the House of Representatives of New York respectively voted to legalize recreational marijuana, which will be submitted to New York Governor Cuomo for signing into law. According to the bill, adults in New York State who have reached the age of 21 will be legalized to use mahjong for entertainment, and residents can also grow marijuana at home according to the quantity requirements. In addition, the bill will abolish the conviction of holding no more than 3 ounces of marijuana in public places and automatically delete the criminal records of those convicted of possessing marijuana.

After the bill is signed, New York will become the 15th state to allow adults to use recreational marijuana. New York Governor Cuomo said the move was a "big step forward" for the state.

5. Biden’s dog has just returned to the White House and bitten again. It was sent back to his hometown for "aggressive behavior".

【CNN】On the afternoon of 29th local time, Biden’s sheepdog "Colonel" bit again after returning to the White House. It is reported that the incident occurred on the South Lawn of the White House, and the victim was an employee of the National Park Service who was working at that time. Subsequently, the White House medical department has inspected the employee, and he returned to work unharmed. Michael Larosa, Biden’s press secretary, told that the Colonel was still "adjusting (adapting) to the new environment".

Biden adopted the "Major" in an animal shelter in Delaware in November 2018. The "Major" is 3 years old and has shown exciting behaviors on many occasions, including jumping, barking and "attacking" staff and security personnel. Last November, Biden slipped and sprained his ankle while playing with "Major". At the beginning of March 2021, "Major" was sent back to Biden’s hometown in Delaware after his aggressive behavior in the White House, and was sent back to the White House soon after.

6. Russian registered the world’s first veterinary COVID-19 vaccine or mass-produced it in April.

Sputnik news agency & radio reported on the 31st that Savenkov, deputy director of the Russian Animal and Plant Health Supervision Bureau, announced that Russia had registered the world’s first COVID-19 vaccine for animals. It is reported that the vaccine, named "Carnivaccov", was developed by the Animal Health Center of the Russian Federation and did not show any side effects in the preliminary test.

It is reported that the clinical trial of the vaccine began in October 2020, involving dogs, cats, minks, foxes and other animals, and it is possible to start mass production in April. Companies from Greece, Australia, Poland, Canada, the United States and Singapore have expressed interest in buying.

7. The Utah Jazz charter plane was hit by a bird: the engine failed and there were many cracks in the fuselage.

【KUTV2】On the 30th local time, the Utah Jazz, an NBA basketball team, collided with a bird after taking off, resulting in engine failure and staged a moment of air fright. Fortunately, the crew turned off the affected engine in time, and finally the plane returned to Salt Lake City Airport safely. After landing, it was found that the nose was stained with blood, and cracks appeared in the nose and wing.

It is reported that the plane originally planned to fly to Memphis, Tennessee, in order to play an away game with Memphis Grizzlies on the evening of the 31st. Delta Air Lines, which is in charge of the accident flight, said that they are communicating with Utah Jazz to fly it to Memphis for the competition as soon as possible.

8. SpaceX test flight When the prototype of the 11th starship landed, it exploded and landed with loud noise and debris flying all over the sky.

【CNN】At 8: 00 am local time on the 30th, the test flight of "Star Boat" SN11 was carried out at the company’s R&D and test base in Bokachica, southern Texas. It is reported that SN11 successfully lifted off to a predetermined height of 6.2 miles after launch, but unfortunately the prototype exploded when it landed. The scene shows debris flying all over the sky. SpaceX engineer John Inspruk said that SN11 failed to land safely, saying that "all data on the spacecraft may have been lost".

SpaceX CEO Musk tweeted a few minutes after the crash: "At least the location of the crater is right!" It is reported that Musk has estimated that the "Star Boat" rocket project will cost about 5 billion US dollars. Since December 2020, SpaceX has carried out four "Star Boat" prototype test flights. In the previous three missions, SN8 and SN9 exploded when landing, and SN10 landed but then exploded.

9. A doorman in new york, USA, has been suspended for sitting idly by against Asian hate crimes.

【CBC】At about 11 noon local time on the 29th, a 65-year-old Filipino woman in midtown Manhattan, new york, was suddenly trampled down by an African-American man. The man also swore at the trampled woman and made racist remarks, but the security guards who witnessed the incident not only failed to help, but also closed the door from inside the building.

On the 30th, the broschi organization in charge of the building said that the doorman had been suspended and would investigate the matter with the trade union. According to a police statement, the Asian woman was seriously injured and has been transferred to new york University Langone Hospital, where she is in stable condition.

10. CDC announced that COVID-19 ranked third among the top ten causes of death in 2020.

According to the data released by the Centers for Disease Control and Prevention (CDC) on Wednesday (March 30th), in 2020, Covid-19 will be the third leading cause of death in the United States, after heart disease and cancer. The data shows that the virus caused nearly 378,000 deaths in the United States in 2020, accounting for 11% of the total death toll of 3.36 million in the United States. In 2020, heart disease killed about 700,000 Americans and cancer killed about 600,000 people.

Another analysis by the agency showed that 34% of COVID-19’s deaths were also attributed to complications caused by viruses, the most common being pneumonia and respiratory failure. In addition, as many as 80% of people who died of the virus had at least one potential health condition that led to their death, the most common being hypertension, diabetes and dementia.

11. Youtube refused to take off the shelves to encourage the robbery of Chinese song executives: no precedent can be set.

【ABC】Recently, employees of Youtube, a social media site, called for the deletion of the 2014 song "Meet the Flockers" by rapper YG, because it contained lyrics encouraging the robbery of Chinese. However, the appeal was rejected by company executives, who said that they must consistently implement the policy and "avoid setting a precedent that may lead us to remove many other music on YouTube."

When the song was published in 2014, no one paid attention to it, and two years later (2016), it triggered a condemnation from the Chinese American community. After causing controversy, this song was once deleted from Youtube by fans. On July 24, 2018, this song was rediscovered on Youtube through YG personal account. By 11: 00 am on March 31, 2021, Beijing time, the number of views had exceeded 110,000, with 3,344 likes and 3,644 clicks.

12. Volkswagen changed its name? Early April Fool’s joke!

Wall Street JournalAccording to the news released by Volkswagen’s American subsidiary on the 29th, in order to reshape the brand image, the company will change the letter K in its original name to T.. Volkswagen means "people’s car" in German, and the name change is to change "people" to "volt", which is the unit of voltage. The announcement said that the revised name will take effect in May, demonstrating the company’s determination to shift its focus to electric vehicles.

However, the press release about this news was quickly deleted from the company official website. Subsequently, the Wall Street Journal reported on the afternoon of 30th that the news of Volkswagen’s name change was a joke on April Fool’s Day, aiming at raising people’s awareness of Volkswagen’s electric vehicles and promoting the upcoming new electric SUV.

13. Married women don’t mind hiring a "man hug" husband for $80 an hour!

The sunA woman named saskia recently hired a professional man for $80 to "hug". According to saskia, she had to leave her husband for a while because of her acting career, and she soon began to feel "lack of touch" and turned to this special service. The woman’s husband doesn’t care about this. He said that they are one-on-one couples, and this hug will not interfere with the relationship between husband and wife.

It should be pointed out that this service is booming in the United States, and the number of requests for professional "hugs" reaches 200 every week.

14. The French Open is restored! Italy absconded for 7 years, and the Mafia was recognized by the police for indulging in cooking.

[Mirror]A 53-year-old member of the Italian mafia named Mark Phelan was wanted by the police and has been on the run for seven years. He fell in love with cooking while hiding, and he also liked to record the cooking process and share it with a YouTube channel created by him and his wife. In the video, he didn’t show his face, thinking that he was "invisible", but he forgot to cover his unique tattoo pattern. As a result, he was recognized by the police and tracked down, and he was arrested.

It is reported that seven years ago, the Italian prosecutor ordered his arrest on the grounds that he was suspected of trafficking drugs and cocaine for the "Ndrangheta Mafia". Since he fled, he has been living in seclusion in a quiet village in the Dominican Republic called Boca Chica. At present, Mark has been extradited to Italy and his YouTube channel has been closed.

15. A Brazilian couple had 14 boys in succession to form a football team.

According to the Brazilian media Uol, a couple in Bahia, Brazil, gave birth to 15 children, the first 14 of whom are sons. Because they love football, they formed a football team with these 14 sons. It is worth mentioning that the names of their 14 sons are Rodrigo, Ronaldo and Robson)…… … all of which begin with R. Cruz, a 44-year-old father, said that he got the name because these Brazilian stars with the R have brought happiness to the whole world.

Last September, the couple finally welcomed their first daughter, Layani, whose name also begins with R. The 39-year-old mother, Rusikred, said that it was finally complete. The couple said that now that they have daughters, they will not regenerate in the future.

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Prison system/Junzhou

Editor/Derrick

Main broadcast/Zixuan

Compilation/Wenma, Derrick, Zavia, Amo, Wen Zhuo, Sanliun

Union chupin

Seattle Chinese Radio, USA

Chinese Radio Vancouver, Canada