1905 movie network news On the evening of December 22, Jiaxing Media, the brokerage company to which Yang Mi and Liu Kaiwei belong, issued a statement announcing that Yang Mi and Liu Kaiwei had signed an agreement in 2018 to peacefully break up and end their marriage.

In the statement, it also specifically stated that "although they will no longer live together as husband and wife, the two will also take care of and raise the children together as relatives in the future." To put an end to the small glutinous rice issue that the majority of netizens are concerned about.

In 2011, Yang Mi and Liu Kaiwei fell in love for the filming of the TV series "Ruyi". In 2012, the two admitted to their relationship on Weibo. On January 8, 2014, Yang Mi and Liu Kaiwei held a wedding ceremony in Bali; on January 19 of the same year, Liu Kaiwei confirmed that Yang Mi was more than three months pregnant. On June 1, 2014, Yang Mi gave birth to her daughter "Xiao Nuomi" in Hong Kong.

In the two years after their marriage, Yang Mi and Liu Kaiwei interacted frequently, and the two often forwarded and interacted sweetly with each other on Weibo. But since 2016, the interaction between the two sides on Weibo has become less and less. In the past two or three years, both of them have produced a lot of new works, but the two sides have almost never promoted each other. On December 3, 2015, Liu Kaiwei forwarded Yang Mi’s new works for the last time. And at the end of 2015, it was when Liu Kaiwei and Yang Mi reported that their marriage was changing.

Until 2018, the two’s Weibo almost stopped interacting. The last time Liu Kaiwei interacted with Yang Mi on Weibo was on April 12, 2018. Yang Mi was caught in a public welfare scam, and Liu Kaiwei forwarded the rumor-refuting article and supported Yang Mi.

And according to an online friend, "It has been rumored for so long, why did Liu Kaiwei and Yang Mi choose to announce the divorce statement today? Because schools in Hong Kong will give students a Christmas holiday from December 22, and the holiday time is not short. In order to protect Xiao Nuomi from being chased by the media, the two of them advised everyone not to disturb Xiao Nuomi."

　　Western Network News (reporter, Liu Wang) Do you dare to take a ride on an online car without the approval of the competent authorities? Recently, a navigation software removed a number of unapproved online car-hailing platforms in Xi’an overnight. Why were these online car-hailing platforms removed? Western Network reporters conducted an investigation.

　　Several ride-hailing platforms were removed from the Autonavi aggregation page

　　Is it difficult to take a taxi during peak hours? Use the Autonavi map to take a taxi. You can call multiple online car-hailing platforms with one click, but in the past two days, many friends who are used to taking a taxi through navigation software have found that the original taxi aggregation page, "Sunshine Travel", "Proper E Line", "Timely Car Use", "An’an Car Use", "Ctrip Car Use", "AA Travel" and other online car-hailing platforms have disappeared. What remains are the four online car-hailing platforms that have obtained the online car-hailing license in Xi’an.

　　Several drivers who had registered on these online ride-hailing platforms told reporters that the online ride-hailing driver port they used issued a notice to them. The notice said that in order to cooperate with the work of Xi’an city regulators, the Xi’an navigation software taxi business was offline from the evening of October 11. Later, the reporter called the Autonavi map taxi line, and the operator told the reporter that the reason why these online ride-hailing cars could not be found was because "there are no cars nearby."

　　Some travel platforms such as "Sunshine Travel" confirmed to the Western Network reporter that on the Autonavi map, the entire Xi’an city does not have its own brand of online car-hailing. The competent authority confirmed to the Western Network reporter that Xi’an has indeed requested the removal of online car-hailing platforms that have not obtained service licenses.

　　Drivers are not happy, passengers complain service can not keep up

　　The way navigation software aggregates illegal online car-hailing platforms has long caused dissatisfaction among some legal online car-hailing drivers in Xi’an. A driver, Master Chen, complained to the Western Network reporter that he spent time participating in the training of online car-hailing drivers and paid a high price to buy vehicles that meet safety standards before obtaining the qualification for quasi-transportation. Drivers of these illegal platforms do not need it. In essence, this is an infringement of illegal operations on legitimate operations.

　　In addition to drivers in the same industry, the "taxi-hailing" aggregation taxi platform has also been dissatisfied by passengers. According to local media reports, Ms. Chu, a resident of Xi’an, had such an experience. "After calling a car, the car experience is not very good. The in-car environment and driver service can’t keep up." Ms. Chu said that she used the Autonavi map ride-hailing function to call a BYD car through an unnamed online ride-hailing platform. The environment and hygiene in the car are not good, and the driver service is not very professional.

　　Map navigation software aggregation network car-hailing platform, who should supervise it?

　　In fact, there are already signs that the navigation software has been removed from the shelves of many online car-hailing entrances in Xi’an. On June 20 this year, Autonavi Map was "discussed" by the management department because the freight of the cruise car was much higher than the freight of the online car-hailing car, and the unauthorized online car-hailing platform was listed on the shelves. The management department asked Autonavi Group to immediately correct the wrong freight information of the cruise car and immediately remove the unauthorized online car-hailing platform. The relevant person in charge of Autonavi Group also promised to remove the unauthorized online car-hailing platform.

　　And people familiar with the matter also revealed that the reason why they "discussed" with Autonavi maps instead of "interviewing" is precisely because the behavior of Autonavi map aggregation network car-hailing is difficult to characterize. In our country, the main responsibility for safe production is borne by enterprises, and the online car-hailing platform is responsible for passengers. Autonavi maps provide the entrance to illegal online car-hailing platforms. In the event of an unsafe accident, does Autonavi map also need to be held responsible? If it needs to be held responsible, is it administrative law enforcement by the surveying and mapping department or the transportation department? On these two issues, there are still legal gaps in local supervision.

　　Reporters found that although the aggregation page of Autonavi maps removed these unapproved online car-hailing platforms, Baidu maps and Ctrip trips can still be searched for online car-hailing platforms such as "Sunshine Travel" and "Ctrip Travel" that have not been approved by the competent authorities.

Traffic information is broadcast every day, and at twelve o’clock in traffic, you can sort out the traffic and car information you need every day to protect your safe travel. Today’s main traffic information includes: Several Opinions on Promoting the Modernization Reform of Civil Aviation Statistics issued by the Civil Aviation Administration, blood donation organized by Shihuang Branch to help volunteer service, and the upgrade package of "5G Dana Intelligent Music Cockpit" added by Han EV flagship … Let’s learn about today’s traffic and automobile events!

First, traffic hotspots

The Civil Aviation Administration issued "Several Opinions on Promoting the Modernization Reform of Civil Aviation Statistics"

Recently, the Civil Aviation Administration issued "Several Opinions on Promoting the Modernization Reform of Civil Aviation Statistics". The development goal put forward is that by 2025, a modern civil aviation statistical system will be initially formed, the statistical investigation system will be more sound, the statistical methods and means will be more scientific, the statistical analysis services will be better, and the statistical system and mechanism will be more perfect. Looking forward to 2035, the modern civil aviation statistical system will be fully established, and the modernization of civil aviation statistical investigation system, methods and means, analysis service and governance capacity will be basically realized.

Second, Hebei Expressway Express

August 30 [Hebei Expressway Road Conditions] Today, the weather turned cloudy to thunderstorms. Shijiazhuang City, Handan City, Langfang City, Tangshan City, Cangzhou City, Qinhuangdao City, Baoding City, Dingzhou City: the limit number is 1 and 6. Beijing: Limit the tail numbers 1 and 6. (The measures to limit the number of counties and cities under the jurisdiction of restricted cities shall be subject to the release of the local traffic control department. )

Huangshi Expressway (G1811): Shitai section of Qingyin/Huangshi Expressway: The underpass of Nanxincheng Station was closed in both directions due to the construction at K318+233 to K318+700.

Taihang Mountain Expressway (S75): Xing-Han section of Taihang Mountain Expressway: Due to the heavy traffic, the two-way vehicles at K44+293 on the upper crossing of Xingtai West Station slowly pass for about 1km.

Shihuang Branch: Organize voluntary blood donation to help volunteer service.

Shihuang Branch combined voluntary service with the activity of "I do practical things for the masses", and organized the staff of headquarters and grass-roots units to carry out voluntary blood donation activities in sections in late August.

Before blood donation, the branch company made careful arrangements, actively publicized and created an atmosphere, initiated blood donation initiatives to employees, and informed them of blood donation instructions. When donating blood, everyone strictly follows the relevant regulations on epidemic prevention and control and unpaid blood donation. Under the guidance of blood station staff, check the health code itinerary, registration information, physical examination, blood test and blood donation, and the well is orderly and orderly. A total of 62 people in the branch signed up for blood donation activities, and 39 people donated blood successfully, donating a total of 12,600 ml of blood, which contributed to the society.

It is reported that since the blood donation activity was launched in 2016, Shihuang Branch has always adhered to the concept of "dedication and service" and organized more than 400 blood donations, which fully demonstrated the spirit of the branch as a "provincial civilized unit".

Third, traffic control traffic police

Traffic Police: bike-sharing enterprises express their condolences to the frontline traffic police and work together to build civilized traffic.

On the afternoon of August 26th, organized by China Communications Broadcasting Hebei Frequency FM101.2, representatives of Shijiazhuang Branch of Hellobike came to the traffic police squadrons in all districts of the provincial capital with caring materials to pay tribute to the traffic police comrades who have been struggling in the front line to maintain the traffic order in the provincial capital, thanking them for their hard work in traffic construction in the provincial capital, and hoping to actively undertake corporate social responsibility and create a more orderly, healthy and green travel environment for the provincial capital citizens by continuing to join hands with the traffic police on duty.

Hellobike donated 120 sets of daily necessities and 4,000 medical epidemic prevention surgical masks to squadrons in Qiaoxi, Xinhua, Yuhua and Chang ‘an. Zhu Lingling, the administrative manager of Hellobike Shijiazhuang Branch, said, "We are well aware of the hardships of front-line traffic police on duty, and thank them for sticking to their posts all the time. I hope that the materials sent can represent the concern and gratitude of all employees in Harbin to the provincial traffic police, and I also hope that they will not forget to take care of themselves when working."

Fourth, industry focus

Han EV flagship push "5G Dana Intelligent Music Cockpit" upgrade package

On August 29th, 2021, BYD brought DiLink4.0(5G) and the "5G Dana Intelligent Music Cockpit" upgrade package for the flagship of Han EV four-wheel drive high-performance version, which was officially listed at Chengdu Auto Show. The upgrade package of "5G Dana Intelligent Music Cockpit" includes four major upgrades: 5G Quick Link, HiFi customized Dana Audio, DiLink4.0(5G) and dual-frequency positioning navigation technology, and the price is 18,000 yuan. Before December 31st, users who purchase the flagship model of Han EV will be offered an upgrade package for a limited time of only 8,000 yuan, and will be given a 5G VIP listening package.

As the flagship car of China New Energy, BYD Han adheres to the concept of "customer first", constantly explores a new realm of intelligent luxury with leading technology, and continuously refreshes the user experience through functional iteration and configuration upgrade. The upgrade package of "5G Dynabar Intelligent Music Cockpit" is fully upgraded in communication technology, car audio, human-computer interaction and navigation technology, which will bring users a more intelligent and luxurious high-end experience and let users enjoy the most fashionable and fashionable smart car life.

The pre-sale is 102,900-140,900 yuan, and the Jietu X90 PLUS Chengdu Auto Show opens for pre-sale.

On August 29th, 2021, Chengdu Auto Show was grandly opened. Jetway Auto made its debut as an independent brand in the four domestic A-class auto shows, and launched the pre-sale of Jetway X90PLUS on the first day of the auto show, with a pre-sale price of 102,900-140,900 yuan.

At this auto show, Jietu X90 PLUS brought two power versions of 1.5T and 1.6TGDI, covering five models of houses, mansions, courtyards, villas and manors. From the name, we can see the intention of Jietu X90 PLUS in creating space and comfort.

Changan Auchan X7PLUS pre-sold 7.99-135,900 yuan and pushed 7 times as a popular gift.

On August 27th, Changan Auchan X7PLUS officially opened the global pre-sale, with an official pre-sale price of 79,900-135,900 yuan. The new car comes standard with a new generation of Blue Whale NE series engines, and there are 9 models with 1.5T+6MT and 1.5T+7DCT power combinations, as well as up to 6 body colors for users to choose from. Together with the pre-sale price, there is also the customer’s car booking rights of "7-fold popular gifts", which brings an ultra-high-value car buying experience far beyond users’ expectations.

As the first flagship PLUS model of Auchan Automobile, Changan Auchan X7PLUS has achieved advanced strength in five aspects: power, intelligence, face value, space and quality, and redefined the best choice of "150,000-class SUV" with the high-value configuration of "five leading industries, five leading peers, five pioneering industries and five standard systems".

57 leapfrog configurations, listed in Shijiazhuang, the 4th generation Emgrand of Geely.

On August 28th, "Emgrand, Walk with the Upward" Geely’s 4th generation Emgrand BMA champion car was officially launched in Shijiazhuang. This new car has launched four models with 1.5L-5MT and 1.5L-8CVT, and the official guide price is 69,900-88,900 yuan.

As the first car of Emgrand family born in BMA architecture, the 4th generation Emgrand has more beautiful body, more space, better comfort, more stable handling, higher quality and stronger technology, and it is advanced in all dimensions in terms of modeling, space, power, quality, technology and safety. The new car is equipped with 13 first configurations of the same class, 16 unique configurations of the same class and 28 leading configurations of the same class. It can be called a car with the highest quality-price ratio and the strongest sense of science and technology of 60,000-80,000 yuan.

Chaodong Rongcheng Great Wall Motor bombed the 2021 Chengdu Auto Show with five brands.

On August 29th, the 24th Chengdu International Automobile Exhibition officially opened. Great Wall Motor’s five vehicle brands, Haval, Tank, Wei Brand, Euler and Great Wall pickup truck, were assembled and debuted, and 12 new models were unveiled, demonstrating the new strength of global technology travel companies.

At the auto show, the booth of Great Wall Motor was bursting with popularity, and the users of the exhibition were bustling, moving Rongcheng with boiling posture.

Five, enjoy the book-today’s good book recommendation: "Wind and rain" edited by Liu Jianhui

Content introduction:This book closely follows the theme of seeking truth from facts and keeping pace with the times. From the perspective of the the Communist Party of China (CPC) Party Congress, it reviews and summarizes the glorious history and fine style of the Party, explores the reasons for the continuous development and growth of the Party, summarizes the valuable ruling experience accumulated by the Party for a long time, and focuses on the important significance of the previous party congresses in the political, economic and social development of China, as well as the international and domestic background and the influence on the historical process of China, highlighting the status and role of the previous party congresses.

The reserved interface of Han series vehicles is in the black shell at the front. The ETC reserved interface can be used for installing driving recorder or ETC equipment. Most people may not know where the reserved interface is. Please share the installation steps and effects of Kailude C1 driving recorder. Just plug in the ETC interface of the original vehicle. This is a two-in-one interface, which does not affect the installation of ETC. Attach a location map.

The installation steps are simple, and the most important thing is to find the reserved interface. Using the crowbar tool, the back shell can be well removed. First, pry the small middle cover from top to bottom and take it down by hand, and then directly take down the pried gaps on the left and right sides of the big shell, so that the reserved interface position can be directly seen.

Kailude C1 driving recorder, the mold corresponding to the vehicle model, and the original one-in-two ETC power plug, crowbar tools, etc.

The model can watch videos on the mobile APP, and the video can also be watched on the big screen of the car. The recorder comes with a wifi mold, and the mobile phone and the car are connected to view without traffic.

foreword

Malignant multiple myeloma(multiple myeloma ； MM) is a kind ofwithMalignant disease characterized by massive proliferation of monoclonal plasma cells in bone marrow. B cell maturation antigen (BCMA) is highly expressed on the surface of MM cells. In the past few years, great progress has been made in various BCMA targeted immunotherapy for recurrent/refractory MM patients, including anti-BCMA monoclonal antibodies, antibody-drug conjugates (ADC), bispecific T cell binders (BITE) and chimeric antigen receptor adoptive T cell therapy (CAR-T). The 63rd annual meeting of American Hematology Society updated some information about the application of BCMA in MM, and based on this annual meeting, the related contents of this paper were sorted out [1].

Immunotherapy targeting BCMA: (1)ADC; 　 (2)CAR-T; 　 (3)BiTE;　

copywriter |　NING

BCell maturation antigen (BCMA)

Also known as TNFRSF17, it is a member of TNF-receptor family, and is called tumor necrosis factor receptor superfamily 17. This receptor is expressed on the surface of B lymphocytes and plasma cells, and is a marker protein of B lymphocyte maturation. Under physiological conditions, BCMA is mainly expressed in plasma mother cells and terminally differentiated plasma cells (PC). Under pathological conditions,BCMA Almost in all MM Tumor cell line (80%–100%) are expressed.The number of BCMA on the surface of malignant PC is much higher than that of conventional PC, which explains why BCMA target has become a battleground for major biological enterprises.

Monoclonal antibody targeting BCMA

SEA-BCMAIt is a new humanized non-fucosylation. IgG1 mAb. The working mechanism of SEA-BCMA may include blocking BCMA activation and its downstream proliferation signal pathway, regulating antibody-dependent cell phagocytosis and enhancing antibody-dependent cytotoxicity.

Its clinical phase I trial (SGNBCMA-001; The preliminary results of NCT03582033) show that it has good safety and combination potential: SEA-BCMA also shows encouraging treatment duration and initial anti-tumor activity in the advanced R/R MM population who have received a lot of treatment before.

Source: blood (2021) 138 (Supplement1): 2740.doi: 10.1182/blood-2021-146047.

Bispecific T Cell cement (BITE)

BiTEs can simultaneously target BCMA on MM tumor cells and CD3ε domain of TCR on T cells. After T cells are combined with myeloma cells, cytotoxic T cells can be activated and secrete cytotoxic factors, thus producing cell killing effect.This part is still in Ⅰ at present./Phase ii.

The following table summarizes the clinical data of bispecific antibodies against BCMA, among which the BiTE bispecific type of BCMA×CD3 is the most common.

Novel trispecific antibody drugs

Researchers are no longer satisfied with treating patients with R/R MM through dual-target therapy.HPN217, an extended half-life (median serum half-life:74 Hours) three specificity. T Cell activation construct (TriTAC)It simultaneously targets BCMA and CD3ε (redirected T cells), and adds serum albumin to prolong the half-life, which can exert cytotoxic effect on myeloma cells.Currently working onR/R MM of 1 /2 Phase I clinical trial for evaluation (NCT04184050). Here are some preclinical data.

Legend: HPN217 mediates the killing effect of autologous T cells of NCG mice on BCMA-dependent/primary MM cells.

Source: blood (2021) 138 (Supplement1): 1185.doi: 10.1182/blood-2021-151880.

CDR101(CDR-lifeCompany’s products)Is simultaneous targeting.CD3、BCMAandPD-L1The trispecific antibody,T cells can be induced into tumor cells expressing BCMA, and the immunosuppressive effect caused by the interaction between PD-L1 and PD-1 can be blocked at the immune synaptic site. Compared with BCMA × CD3 bispecific drugs, CDR101 leads to at least a tenfold increase in T cell-mediated tumor cell lysis, and performs better than the combination of PD-L1 inhibitor and BCMA × CD3 bispecific drugs.CDR101 It may become a new ready-made treatment, providing a more lasting response and a higher cure rate. CDR101 Has excellent drug-like characteristics, high stability and high stability.CHOHigh yield of expression.Based on these findings, new trispecific immunotherapy drugs have high clinical potential and promising clinical application [2].

Antibody drug conjugate (ADC)

After recognizing BCMA on the cell surface, ADC internalizes it into myeloma cells. Through the degradation of lysosomes or endosomes, the payload is released, causing cytotoxicity.

Belantamab mafodotin (GSK2857916)Is targeted by humanization.BCMA IgG1 andMMAF(tubulin polymerization inhibitor). Belantamab mafodotin was approved by the US Food and Drug Administration (FDA) in 2020 to treat patients with R/R MM.This is the first target approved for listing.BCMAimmunotherapy,A multicenter phase II clinical study (NCT03525678) confirmed that the recommended regimen for patients was 2.5 mg/kg, once every three weeks, but the toxicity of the drug was mainly manifested in thrombocytopenia and pericorneal lesions, such as microcystic epithelial changes or superficial punctate keratopathy. In addition to belantamab mafodotin, several other ADCs targeting BCMA, such as AMG 224, MEDI2228 and HDP-101, have also conducted many preclinical or clinical studies at different stages.

Legend: Incidence rate of adverse events caused by Belantamab mafodotin at 2.5 mg/kg and Q3W.

Antibody drug conjugate (ADC) joint test.

In the joint experiment, there are two schemes: belantamab+DEX (dexamethasone) and belantamab+DEX+POM.

belantamab(2.5 mg/kg Q3W) and DEX(20-40 mg Q1W,threeCycle) jointAfter use, the objective remission rate (ORR) was 46%, the complete remission rate (CR) was 14%, the median progression-free survival (PFS) was 4.9 months, and the median overall survival (OS) was 7.4 months. The incidence of AEs from high to low is anemia (83%), keratopathy (82%; Gr3/4: 56%), thrombocytopenia (70%) and so on.

belantamab+DEX+POMUnion ofIn the experimental scheme, the ORR was 88.9%(48/54), and the CR and PR rates were 24.1%(13/54) and 20.4%( 11/54) respectively. However, keratopathy (96.9%) was also the most common AE, and 56.7% of such patients had reached Gr 3/4. These two studies show that POM and DEX may have a positive effect on the curative effect of belantamab. howeverKeratosis is still a challenge in the treatment process.

Legend: Detailed rules and results of belantamab+DEX (Dexamethasone) joint trial scheme.

Source: Blood 2021; 138 (Supplement 1): 1642. doi: https://doi.org/10.1182/blood-2021-149791

CAR-Ttherapy

nowTwo CAR-T therapies based on BCMA have been approved for marketing.And is used for treating patients with multiple myeloma.

Source: "CAR-T therapy targeting BCMA"

7.1

Cilta-cel (Carvykti) for Orense injection.

Sidaki Orense injection(Cilta-cel,Carvykti) yes2022year2moon28Listed in China (NMPAApproved for listing/FDAFormal approval) targeting.BCMAofCAR-TCell products, jointly developed by Janssen and Legendary Bio, Legendary Bio owns 70% interests in Carvykti Greater China and 50% interests overseas.

In CARTITUDE-1 trial, the overall remission rate was 97%, the 18-month progression-free survival rate was 66%, and the 2-year progression-free survival rate was 61%. The 18-month overall survival rate is 81%, and the 2-year overall survival rate is 74%. Compared with similar products, this data is very gratifying. According to the latest news from Kingsley, the sales of the legendary BCMA CAR-T new drug Carvykti in the first half of the year was 24 million US dollars.

7.2

Abecma（Ide-cel）

2021yearthreemoon26Day,FDAapproveBaishimei SquibbAbecma(Ide-cel)be listedAbecma is also a BCMA-oriented CAR-T cell therapy, which is customized from patients’ autologous T cells. Clinical data show that the overall remission rate of all patients is 72%, of which the complete remission rate is 28%; Even for patients who have received various regimens, the remission rate of Abecma still reaches 72%, and this remission is very lasting, and 65% of patients are over 12 months.

Legend: preparation principle of Abecma

7.3

Iqalunsei injection

In addition, June 2, 2022Reindeer biology/Xinda biologyAnnounce BCMA CAR-T therapyIqalunsei injectionThe listing application was obtained.NMPAAccepted, it is expected to become the first domestic independent research and development of the whole process.CAR-Ttherapy. The clinical research data reported at the 63rd ASH annual meeting in 2021 showed that the overall remission rate (ORR) was 94.9%, and the complete remission rate/strict complete remission rate (CR/sCR) was 58.2%, showing the excellent safety and effectiveness of Iqalunsei injection.

Source: NMPA official website

7.4

The clinical trial of CAR-T therapy targeting BCMA is as follows

summary

Judging from the listing situation,Belantamab mafodotin (GSK2857916) is composed of humanized targeting BCMA IgG1 and MMAF (tubulin polymerization inhibitor), which is the first targeted BCMA immunotherapy approved for marketing. At present, there are two CAR-T therapies that have been put on the market, developed by Bristol-Myers Squibb respectively.Abecma(Ide-cel), developed in cooperation with Janssen)/ Legendary Biology.Sidaki Orense injectionFrom the data point of view, the latter effect is better, the ORR is increased from 72% to 97%, and other indicators are relatively better. On June 2nd, 2022, Reindeer Bio/Cinda Bio announced BCMA CAR-T therapy.Application for marketing of Iqalunsei injectionIt has also been accepted by NMPA, and it is expected to become the first CAR-T therapy independently developed in the whole process in China. Let us wait and see! From the therapeutic point of view, CAR-T therapy is at the forefront in terms of clinical data and market situation, but we can’t simply judge the advantages and disadvantages of these products. For example, better anti-BCMA CAR-T cell therapy requires more complicated preparation conditions and more expensive treatment costs, which are unbearable for ordinary families. Therefore, while continuing the existing research, it is necessary to study the potential mechanism affecting the curative effect in order to optimize BCMA targeted immunotherapy.

　 　

Legend: Comparison of clinical efficacy between different immunotherapy products targeting BCMA (see [1] for specific clinical data).

reference data

[1]Targeting BCMA to Treat Multiple Myeloma: Updates From the 2021 ASH Annual Meeting. Front Immunol. 2022 Mar 7; 13:839097. doi: 10.3389/fimmu.2022.839097. PMID: 35320942; PMCID: PMC8936073.

[2] Blood 2021; 138 (Supplement 1): 1583. doi: https://doi.org/10.1182/blood-2021-152160

[3] Blood 2021; 138 (Supplement 1): 1642. doi: https://doi.org/10.1182/blood-2021-149791

* Tweets are used to transfer knowledge. If you have any questions about copyright, please contact BiG Bio-innovation Society within 30 days after the publication of this article.

　　() The Record Form of Investor Relations Activities was released on April 12, and the company was investigated by two institutions on April 11, 2023. The types of institutions are other securities companies. The main contents of investor relations activities are introduced:

　　Q: What was the sales volume of BYD and Tengshi brand in March?

　　A: BYD sold 207,080 vehicles in March 2023, including 206,089 passenger cars, up 97.5% year-on-year; There are 13,312 passenger cars exported. BYD Tengshi D9 ranked first in the "Sales List of New Energy Luxury MPVs with an average transaction price of 415,000" for three consecutive months with a score of 10,398 units (up 42% from the previous month), and continued to consolidate its position as a "new benchmark for the value of new energy luxury MPVs in China".

　　Q: What’s the feedback from BYD Seals?

　　A: Since its listing, BYD Seal has become an explosive model in the sports market with its excellent quality and leading strength. As the world’s first production car equipped with CTB battery body integration technology, Seal is not only BYD’s practical exploration of the next generation of electric vehicles, but also the realization of its innovative technology in products, and it is also BYD’s masterpiece in the advanced technology field of electric vehicles. On April 7th, CCTV’s third "China Automobile Fengyun Festival" came to a perfect conclusion, and BYD seal, a marine leopard, won the highest prize "Jury Award" and became the biggest winner of this "Festival". This award is not only a high recognition of BYD Seals, but also an authoritative hardcore endorsement comparable to the purchase guide.

　　Q: What is the overseas response of BYD models?

　　A: BYD has actively deployed its overseas business, and has successively entered the passenger car market in Australia, Colombia, Brazil, Singapore, Costa Rica, Thailand and other countries, which has been widely concerned and loved by local consumers. Recently, Thailand AutoLife official website data shows that in March, the number of BYD ATTO3 cards reached 2,434, winning the title of pure electric vehicles in Thailand for the third time in a row. In the first quarter, the number of BYD ATTO3 licenses was 5,542, accounting for 37.5% of the total number of pure electric vehicles in the first quarter, and it continued to lead the pure electric passenger car market in Thailand.

　　Q: Please introduce BYD’s design concept?

　　A: Since Wangwang brand appeared, its subversive core technology has been widely concerned, and the discussion has always been hot. At the same time, highly recognizable product design has also received great attention. Looking up at the car design inspiration comes from the universe, which is a space that contains infinite time, energy and emotion. The place leading to this space is called "dimension door", which is the most recognizable part of looking up to the brand-new family visual identity of the car, hoping to bring a brand-new visual experience to users. Looking up at the front face design of U8 is the most recognizable part of modeling. Dimension door’s family-style design language is integrated. A large area of front and rear lighting design creates a visually full sense of volume. Headlight lines outline the image of dimension door, presenting the ultimate sense of science and technology and futurity. Driving outdoors in the wilderness and in urban traffic shows its recognition. The local light-emitting unit follows the lattice air intake grille, and the diamond light particles are regularly arranged, which changes the gorgeous lighting effects in the scenes of unlocking and welcoming guests, so that every departure is full of ritual.

　　Q: Please introduce the highlights of BYD’s cloud technology?

　　A: On April 10th, BYD released a new energy-specific intelligent body control system-Yunqi. The intelligent body control system of Yunqi is developed by BYD, which also indicates that BYD has become a China automobile enterprise that can independently master the intelligent body control system. The product matrix of Yunqi includes Yunqi -C, Yunqi -A, Yunqi -P and other products, which will greatly enhance the driving experience of consumers from the dimensions of comfort, control, safety and off-road. Yunbi can effectively restrain the change of body posture, greatly reduce the risk of vehicle rollover and reduce the sitting displacement of drivers and passengers. At the same time, the cloud chariot system can effectively protect the car body under complex road conditions such as snow, mud and water, avoid the collision damage of the whole car caused by terrain, improve driving comfort and safety, and realize the double protection of people and cars; BYD Co., Ltd. is mainly engaged in automobile business, mobile phone parts and assembly business, rechargeable battery and photovoltaic business, including new energy vehicles and traditional fuel vehicles, and actively expands the business field of urban rail transit. The company’s main products are rechargeable batteries and photovoltaics, mobile phone components and assembly, automobiles and related products. BYD’s leading position in the global new energy vehicle field. In 2019, BYD’s new energy vehicle product structure was further improved, and its sales volume still ranked among the top in the world.

　　Details of participating institutions are as follows:

Name of participating unit Category of participating units Name of participants Guoxin Securities securities company — individual other Yu Xiaofei

CCTV News:In August of this year, a video of an online cargo anchor stopped by the police during the live broadcast was circulated on the Internet. The video was only 30 seconds long, but it attracted a lot of netizens’ attention, and they speculated why the anchor was taken away by the police during the live broadcast. Recently, the Shanghai police confirmed that this video took place in an arrest operation by the police in Hangzhou, Zhejiang Province. At that time, the network anchor and his operation team were conducting a live webcast to bring goods, and they were selling counterfeit and infringing goods.

Shanghai police confirmed to reporters that this video took place in an arrest operation in Hangzhou, Zhejiang Province on August 28. This live broadcast room belongs to a live broadcast anchor named Silent M07. At that time, she was broadcasting live with her operation team. With the stunned expression of the anchor and the appearance of plainclothes policemen, the whole live broadcast came to an abrupt end, and this scene also shocked hundreds of thousands of netizens who were watching the live broadcast.

On the spot, the police controlled 7 people, in addition to the anchor with the goods, there are alsoFourStaff of the operation team and two staff of the supplier. A large number of goods, such as clothing, shoes and hats, jewelry and watches, were also seized at the scene, which was the reason for this action.　

More than 50 people were arrested in 8 dens for manufacturing and selling counterfeit goods.

Not only that, but at the same time, multi-channel police launched operations in Zhejiang and Guangdong. According to the police, the goal of this operation is to crack down on criminal gangs that manufacture and sell counterfeit goods. During the operation, more than 50 criminal suspects were arrested, 8 dens were investigated, and more than 3,000 counterfeit luxury brands’ bags, clothing and other commodities were seized on the spot.

Knowing the fake and selling fake "online celebrity" anchor has become a sales promoter.

Recently, the Shanghai police announced the latest development of the case. Of the more than 50 suspects arrested at present, 41 have been arrested by the procuratorate, and the case is under further investigation. Then, how did this anchor with a million fans go to the road of knowing fakes and selling fakes, and how did it attract the attention of the police? During the investigation, the police found that the anchor tried every means to avoid the brand of the goods he sold in the live broadcast. All indications showed that the anchor and members of the live broadcast team knew that a large number of goods they sold were counterfeit and infringing goods.

So who is this anchor who was taken away? According to the police, the anchor network is named Silent M07, whose real name is Liao, and he is 27 years old this year. In 2017, she signed a contract with a brokerage company to become an online shopping anchor, and began to open a live broadcast room on a well-known e-commerce platform, specializing in women’s wear and accessories. Due to his professional experience as a graphic model, Liao accumulated millions of fans in just three years and became a "head anchor".

There are a lot of abnormal phenomena in the live broadcast that attract the attention of the police.

As one of the many anchors with goods, why do the police pay so much attention to Liao’s live broadcast? Things have to start from May this year. This year, affected by the epidemic, the online shopping form of live broadcast with goods is increasingly recognized by netizens, but there are a lot of unusual phenomena in Liao’s live broadcast.

During the police investigation, it was found that Liao lived for nearly seven or eight hours every day, sometimes as long as 10 hours, and lived almost every day all year round. In the long-term live broadcast, there are often some clothes, jewelry, watches, etc. suspected to be well-known luxury brands. However, Liao never clearly stated the brand of the goods in the live broadcast room, and also blocked the trademarks on the goods.

Deliberately compare the counter price when displaying fake goods.

At the same time, when she shows the goods, she often takes out the genuine counter price as a comparison. Some luxury goods that cost tens of thousands or even hundreds of thousands are only one-tenth or even lower when she broadcasts live, so as to attract consumers to buy.　

Not only that, the brand logo will be covered in all the links of goods suspected of infringement. At the same time, the police found that all the live broadcast pages would be hung with the words "download, delete and play back, keep up with the rhythm", which is very different from the practice of retaining playback in the general live broadcast room.

Unscrupulous merchants use "online celebrity Live" to increase the sales of fake goods.

Because of the strong ability to bring goods, fake merchants have asked Liao to bring goods. Merchants come here, and Liao’s team accepts all the orders, and the business is getting bigger and wider.　

The police investigation found that the fakes recommended by Liao’s live broadcast came from different businesses. Because the traditional online shopping platform has made great efforts to investigate and deal with counterfeit and infringing goods, in order to expand its sales,business operatorI met Liao’s live broadcast team through an intermediary introduction.

The words "a little better" in the mouth of merchants are very implicit. Usually, the prices of their goods are close to genuine prices, and no one cares at all, but they are enthusiastically sought after by fans in the live broadcast room.

The fake merchants with high commission also provide extra appearance fees.

Selling fake goods not only brings huge commission income to Liao’s team, but also provides an extra appearance fee for the fake merchants. Under the temptation of dual interests, Liao’s live broadcast room began to become a popular channel for the sale of counterfeit goods. Police investigations found that nearly 30 of the hundreds of businesses that cooperated with Liao were suspected of selling counterfeit luxury goods.

Many fake merchants have come to the door to ask for goods, and Liao also accepted them according to the order. At the same time, the live broadcast platform is not supervised, and the brokerage company never asks questions, which has become a hotbed for illegal crimes.

In the first three quarters, there were 21,900 complaints related to live broadcast.　

Not long ago, the statistics of the first three quarters of 2020 of the national 12315 platform released by the State Administration of Market Supervision showed that. In the first three quarters of this year, complaints about online shopping accounted for 31.85% of the total number of complaints and reports, and a total of 21,900 complaints and reports related to live broadcast were received, up 479.60% year-on-year, and live broadcast claims accounted for nearly 60%. The demands related to live broadcast mainly focus on jewelry, clothing, shoes and hats, household items and so on. Immediately the annual "Double Eleven""Is coming, how to make the live broadcast bring benefits and convenience to buyers, but also more reassuring, which is an urgent problem for live broadcast platforms, online shopping platforms, merchants and anchors.

　　　"AITO asked the M5 Smart Driving Edition to give me a big surprise. The experience it brought me in terms of intelligence is indeed industry-leading." After the test ride, Zhu Jun Orange, the owner of M7, said so.

　　A few days ago, the first AITO Wenjie M5 series car equipped with Huawei ADS2.0 advanced intelligent driving system and HarmonyOS Intelligent Cockpit 3.0 opened a test ride experience in Yuzhong District, Chongqing, which was also the first appearance of the car in Chongqing. Many consumers went to experience the new driving experience brought by Huawei’s advanced intelligent driving system, and the scene was very popular.

　　A motorcade waiting for consumers to try out. Photo courtesy of the organizer Hualong. com-New Chongqing Client

　　Chongqing is often called "8D Magic City" by netizens because of its complicated roads. He You, the owner of M5EV, mentioned that drivers who can drive in Chongqing can drive all over the country, and the intelligent driving system that can withstand the road test in Chongqing must be relatively mature. Huawei’s advanced intelligent driving system equipped with AITO’s M5 Intelligent Driving Edition has performed well in the trial ride in Chongqing.

　　It is understood that the trial route starts from chongqing heaven and earth, starts along Jiabin Road, passes Huacun Interchange, Jiahua Bridge and Lijiaping Interchange, and finally returns to chongqing heaven and earth. This line is located in the center of Chongqing, and there are endless traffic all day, including tunnels and many viaducts with complicated routes.

　　AITO asking the world M5 intelligent driving edition. Photo courtesy of the organizer Hualong. com-New Chongqing Client

　　During the test ride, Huawei’s advanced intelligent driving system always finds the right driving lane automatically according to navigation and road conditions under safe conditions, and actively seeks opportunities to enter. This broke the past cognition of many consumers on the scene about intelligent driving system, and broke their concerns about intelligent driving extending commuting time. "The intelligent driving system I used to know will always take the initiative to avoid it for safety," He You said. "But it is very flexible and will actively look for opportunities to change lanes and overtake."

　　Zhao Xinglin, the owner of Wujie M5, started the live broadcast when he tried to ride the AITO Wujie M5 version, and shared his driving experience with the riders who could not come to the scene. As an "old driver" who has been driving for nearly 20 years, she highly recognizes the intelligence of this model. In her view, the design of this intelligent driving system is very close to daily life and can respond to various problems encountered by car owners in the driving process in a timely manner. She said: "For example, when we are driving, we often encounter some drivers forcibly cutting in line, and AITO asks the M5 Smart Driving Edition to firmly hold its own lane at this time, while avoiding the safety hazards caused by this situation."

　　Event site. Photo courtesy of the organizer Hualong. com-New Chongqing Client

　　According to the staff, Huawei’s advanced intelligent driving system adopts Huawei’s first intelligent driving interactive game algorithm, which solves the problem that intelligent driving encounters difficult road conditions in complex scenes, and can solve more than 70% of the interactive scene takeover problems, shortening the transit time by 40%, making the driving performance of AITO’s M5 intelligent driving version more like an experienced "old driver".

　　In addition to the flexible "silky" experience, intelligent driving also brings more safety protection to car owners. Zhu Jun Orange, who is engaged in the IT industry, already knows a lot about intelligent driving system, but he was deeply impressed by the safety performance of Huawei’s intelligent driving system. After the test ride, he also had a higher degree of trust in the safety performance of the car’s intelligent driving system. He said: "Its lane change avoidance, acceleration and deceleration are all logical, and it can also simulate the driving habits of real people."

　　According to reports, the fusion sensing system of AITO Zhijie M5 Intelligent Driving Edition is equipped with an overhead lidar, three millimeter-wave radars, 11 high-definition camera groups for lateral and forward visual perception and 12 ultrasonic radars, which can realize the perception of moving and static targets. Its farthest detection distance is about 200 meters, and the horizontal detection angle reaches 120 degrees. In the face of pedestrians or animals suddenly rushing out of the blind area of view, or vehicles parked on the roadside suddenly open the door, it can also realize emergency braking or lane change avoidance, and protect the safety of people and vehicles to the greatest extent. "It protects every owner like a knight," Zhao Xinglin described the safety and reliability of this model.

　　Huawei ADS2.0 advanced intelligent driving system is a blessing for the safety of AITO’s M5 intelligent driving version, which is superimposed with the construction of HarmonyOS’s hot ecology. In addition, HUAWEI DriveONE three-in-one electric drive system helps improve the performance of this model, making it safer, smarter and better. Huawei is bringing new variables to the intelligent driving industry.

Nearly 950 days after Lei Jun announced that he would "put all his reputation on the line", Xiaomi Automobile finally arrived.

On November 15th, the Ministry of Industry and Information Technology publicized the declaration list of the 377th batch of new products in the Announcement of Road Motor Vehicle Manufacturers and Products, among which two pure electric cars with Xiaomi brand appeared.

According to the public information, the models of the two Xiaomi brand cars are SU7 and SU7 Max/Pro respectively. In terms of size, the length, width and height are 4997mm, 1963mm and 1455mm, respectively, and the wheelbase is 3000mm, so they are positioned as C-class cars.

In terms of power battery, SU7 is equipped with BYD’s lithium iron phosphate battery, while SU7 Max/Pro is equipped with Contemporary Amperex Technology Co., Limited’s ternary lithium battery; As for the motor, the motor on SU7 comes from United Automotive Electronics Co., Ltd., and the peak power of the driving motor is 220kW, while the motor on SU7 Max/Pro comes from Suzhou Huichuan United Power System Co., Ltd., and there are two power options: 220kW and 275kW.

According to the information disclosed by the Ministry of Industry and Information Technology, the production address of Xiaomi Automobile is "No.21 Courtyard, Huanjing Road, Beijing Economic and Technological Development Zone". It is also reported that Xiaomi’s automobile factory in Yizhuang, Beijing is under construction. The construction of the project is divided into two stages. The first stage began in April 2022 and has begun to take shape. According to Xiaomi’s previous plan, Xiaomi Automobile will be listed in the first half of next year.

The official announcement of Xiaomi Automobile is more exciting than rice noodles in the secondary market. As early as two months ago, the concept of Xiaomi Automobile OEM was heated up by the market. In early November, the news that BAIC Group executives were photographed by the media to attend the closed meeting in Xiaomi Science Park added new evidence to the "rumor that BAIC OEM Xiaomi Automobile", but from the current point of view, Xiaomi Automobile did not choose the direction of OEM.

Although the trademark of Xiaomi’s new car is "Xiaomi Brand", the name of the declared enterprise is Beijing Automotive Group Off-road Vehicle Co., Ltd.. In this regard, industry insiders said that Xiaomi may not solve the problem of production qualification for the time being, and needs the production qualification provided by BAIC. To obtain production qualification, it generally depends on acquiring other automobile brands or taking the OEM route, or obtaining qualification through self-built factories. Xiaomi chooses the latter, which takes a certain amount of time and process, but the products should seize the window period to grab the market, so Xiaomi may continue to apply for independent qualification while using BAIC’s qualification for production.

After Xiaomi’s official announcement on November 15th, Beiqi Blue Valley, the concept of Xiaomi’s OEM, also opened higher and went lower on the 16th, closing up slightly by 0.27%. However, the Xiaomi automobile industry chain has ushered in a collective carnival. According to media reports, insiders revealed that Lei Jun set a sales target of 100,000 vehicles for Xiaomi automobile in 2024 and delivered a total of 900,000 vehicles in the next three years. Such a considerable sales scale naturally brings direct benefits to enterprises in the Xiaomi automobile industry chain, and the capital market has turned to pay more attention to Xiaomi automobile industry chain enterprises.

On the 16th, Jiayun Technology, which cooperated with Xiaomi in marketing, and the co-creation data of smart camera products which cooperated with Xiaomi Eco-chain Enterprise (Chuangmi Technology) all had a daily limit of 20cm, and Yinbaoshan, which provided structural products for Xiaomi, had a new daily limit, while companies that directly provided parts for Xiaomi’s car-making were mixed. According to public information, Titanium Media App has sorted out the list of some enterprises related to Xiaomi automobile industry chain:

Kaizhong stock (603037.SH)

11

Month 1

six

Daily rise and fall: 1

0.00%

Latest market value: 3

5.82

a hundred million

The company is mainly engaged in the design, R&D, production and sales of shock-absorbing components of automobile chassis suspension system and lightweight pedal assembly of control system, as well as the R&D, production and sales of special polyurethane elastomers such as high-performance polyurethane load-bearing wheels in the field of non-automobile parts.

The company’s vibration damping products have synchronous development business with Xiaomi Automobile, and the online control dynamic product field invested by the company has synchronous development business with Xiaomi Automobile.

Aotejia (002239.SZ)

11

Month 1

six

Daily rise and fall:

10.07%

Latest market value: 9

9.24

a hundred million

The company is mainly engaged in the research, development, production and sales of various automobile air-conditioning compressors and automobile air-conditioning systems.

In September 2023, Aotejia said on the interactive platform that Xiaomi Automobile is a company customer, and according to the current fixed-point situation, it is expected to provide automotive thermal management products to this customer.

Pengling shares (300375.SZ)

11

Month 1

six

Daily rise and fall:

7.22%

Latest market value:

49.33

a hundred million

The company is an automobile parts supporting enterprise integrating design, research and development, production and sales. The main products are automobile fluid pipes and sealing parts.

The company said that it will provide fluid pipeline products for Xiaomi Automobile.

Yachuang Electronic (301099.SZ)

11

Month 1

six

Daily rise and fall:

6.60%

Latest market value:

45.88

a hundred million

Authorized distributor of electronic components, the specific products include photoelectric devices, memory chips, passive components and discrete semiconductors, etc. The products are mainly used in the field of automotive electronics.

The company said that it has indirectly carried out business cooperation with Xiaomi Automobile, and it is now in a small batch stage.

Liyuan Information (300184.SZ)

11

Month 1

six

Daily rise and fall:

-5.69%

Latest market value:

80.32

a hundred million

Mainly engaged in the promotion, sales and application services of IC and other electronic components.

The products of ROHM (Roma), JAE (Avionics) LUMILEDS (Lumens), KDS (Vacuum), ST (Italian), ON (On) are directly and indirectly supplied to Xiaomi and its foundries, which are mainly used in various terminal products of Xiaomi. For Xiaomi Automobile, at present, the company only carries out pre-sample delivery and small supply, and the company will continue to pay attention to the cooperation with Xiaomi Automobile.

Faw fuwei (600742.SH)

11

Month 1

six

Daily rise and fall:

1.08%

Latest market value:

76.31

a hundred million

Products include the design, research and development, manufacture and sales of automobile parts such as automobile seats, instrument panels, door panels, seat frames, bumpers, grilles, rearview mirrors, auto filter, automobile lighting devices, automobile stamping products, wheel assemblies, automobile electronics, etc.

The company said that a number of molecular companies have entered the purchasing group of Xiaomi Automobile, but they have not obtained the mass production business of Xiaomi Automobile.

Weifu Hi-Tech (000581.SZ)

11

Month 1

six

Daily rise and fall:

0.25%

Latest market value:

163.12

a hundred million

The main business products are diesel fuel injection system products, automobile exhaust aftertreatment system products and intake system products.

The company indirectly shares the enterprise United Automotive Electronics Co., Ltd. as the supplier of Xiaomi automobile engine.

Wanxiang Qian Chao (000559.SZ)

11

Month 1

six

Daily rise and fall:

0.18%

Latest market value:

181.71

a hundred million

Specializing in the production of chassis and suspension system, automobile braking system, automobile transmission system, automobile fuel exhaust system, hub unit, bearings, precision parts, construction machinery parts and other automobile system parts and assemblies.

The company said that the fast drive shaft products have been supplied to Xiaomi Automobile.

Huayu automobile (600741.SH)

11

Month 1

six

Daily rise and fall:

-0.40%

Latest market value:

548.89

a hundred million

The main business covers automobile interior and exterior accessories, metal forming and molds, functional parts, electronic and electrical parts, hot working parts, new energy sources, etc.

The company’s products have been partially supplied by Xiaomi automobile related models.

Yin Lun stock (002126.SZ)

11

Month 1

six

Daily rise and fall:

-0.66%

Latest market value:

143.99

a hundred million

Specializing in research and development, manufacturing and sales of various heat exchangers and tail gas aftertreatment products.

In October 2023, when asked whether it had business dealings with Xiaomi Automobile, the company indicated that it had obtained several orders for thermal management products from customers.

Jin Rong Tian Yu (300988.SZ)

11

Month 1

six

Daily rise and fall:

0.13%

Latest market value:

32.76

a hundred million

Focus on technology research and development, manufacturing and product sales of precision metal parts and new energy storage products in the whole industry chain.

In September 2023, the company said on the interactive platform that it had obtained the supporting business of new energy vehicle products such as Xiaomi in the field of new energy vehicles.

The supplier of lithium iron phosphate battery for Xiaomi Automobile is Foday Battery, a wholly-owned holding company of BYD.

Huichuan Technology (300124.SZ)

11

Month 1

six

Daily ups and downs:-

1.10%

Latest market value:

1627

a hundred million

Specializing in industrial automation and new energy related products research and development, production and sales.

Xiaomi automobile engine suppliers include Suzhou Huichuan United Power System Co., Ltd., a holding subsidiary of the company.

Shangluo Electronic (300975.SZ)

11

Month 1

six

Daily rise and fall:

6.50%

Latest market value:

57.87

a hundred million

Mainly for electronic product manufacturers in network communication, consumer electronics, automotive electronics, industrial control and other application fields, providing them with electronic components.

At present, the company indirectly supplies electronic components such as resistance-capacitance sensor, diode and power chip to Xiaomi automobile through Tier1 supplier.

Aerospace Zhizao (300446.SZ)

11

Month 1

six

Daily ups and downs:-

4.52%

Latest market value:

126.53

a hundred million

The main business includes the production and sales of information anti-counterfeiting materials, electronic functional materials and fine chemical materials.

On July 22, 2023, the company said on the interactive platform that its subsidiary Aerospace Molding has successfully entered the supplier system of Xiaomi Automobile and carried out collaborative design of interior and exterior decoration products, and some products have obtained mass production orders.

Haiteko

(

301022.SZ

)

11

Month 1

six

Daily fluctuation: 3.60%

Latest market value: 2.702 billion

Mainly engaged in research and development, design, manufacture and sales of injection molds and plastic parts.

Haitaike said on the interactive platform that the company’s automobile injection mold has been applied to new energy vehicles such as Xiaomi.

Xingyuan zhuomei

(

301398.SZ

)

one

one

Month 1

six

Daily rise and fall

：

-4.04%

Latest market value:

4.842 billion

Xingyuan company has a very mature process system in automobile cylinder, bracket mold, gasoline engine cylinder mold and aluminum radiator mold.

According to the records of the company’s investor relations activities in January 2023, the major domestic new energy vehicle brands under development and expansion include Xiaomi Automobile.

Electrical alloy

（300697.SZ）

11

Month 1

six

Daily fluctuation: 1.96%

Latest market value: 38.17

a hundred million

The main business is the research and development, production and sales of copper and copper alloy products. The main products are divided into electrified railway catenary series products and copper bus series products.

The semi-annual report of 2023 shows that the high-voltage connectors produced by the company are indirectly used in Xiaomi Automobile.

Xiangxin technology

(

002965.SZ

)

11

Month 1

six

Daily fluctuation: -0.95%

Latest market value: 8.351 billion

Specializing in research and development, production and sales of precision stamping dies and metal structural parts.

The company said that it has established a cooperative relationship with Xiaomi Automobile.

Molding technology

(

000700.SZ

)

11

Month 1

six

Daily fluctuation: 3.20%

Latest market value: 8.005 billion

Mainly engaged in the production and sales of car bumpers, rubbing strips and other automotive decorative parts.

BAIC Molding, the company’s shareholding enterprise, is a supplier of Xiaomi automobile.

Demaishi

(

301007.SZ

)

11

Month 1

six

Daily rise and fall:

-1.17%

Latest market value: 2.984 billion

Our main business is research and development, production and sales of precision shafts and precision cutting parts.

The company said that the company’s products are not directly supplied to Xiaomi Automobile, but a directional screw produced by the company was finally used in Xiaomi Automobile.

BYD (002594.SZ)

11

Month 1

six

Daily ups and downs:-

0.14%

Latest market value:

6937

a hundred million

The layout covers the fields of automobiles, batteries, electronics, new energy and rail transit.

The supplier of lithium iron phosphate battery for Xiaomi Automobile is Foday Battery, a wholly-owned holding company of BYD.

Contemporary Amperex Technology Co., Limited (300750.SZ)

11

Month 1

six

Daily ups and downs:-

1.81%

Latest market value:

7967

a hundred million

Focus on the research and development, production and sales of power battery systems and energy storage systems for new energy vehicles.

The company supplies ternary lithium-ion batteries for Xiaomi Automobile.

(Author | Li Jian)

　　"Trams sell well, all because of the large fuel tank." Many investors are so ridiculous. Extended-range hybrid vehicles have eliminated consumers’ anxiety about the endurance of pure electric vehicles, and the share price of LI-W (02015.HK) has been hitting record highs, becoming the first component of the Hang Seng Science and Technology Index (HSTECH).

　　However, shortly after Ideal announced the delivery data of nearly 35,000 vehicles in August, the major shareholder Wang Xing couldn’t wait to continue to "sell and sell"; The growth rate of LI’s monthly delivery volume has slowed down significantly; In addition, in the context of the sharp rise in raw material prices, it is also facing more fierce competition in the price war of the whole vehicle. However, LI is determined to develop pure electric products that have suffered heavy bicycle losses.

　　Wang Xing reduced his holdings by nearly 2 million shares.

　　According to information disclosed by HKEx, Wang Xing, CEO of Meituan-W (03690.HK) and non-executive director of LI, reduced his holdings of LI for four consecutive days. From September 12th to 15th, Wang Xing reduced his holdings by 1,947,900 shares, with an average price of HK$ 157.84 to HK$ 160.51, and cashed in more than HK$ 300 million.

　　On September 3rd, LI announced that a total of 34,914 new cars were delivered in August 2023, up 2.28% from the previous month. So far, the cumulative delivery volume of LI in 2023 reached 208,200 vehicles, a year-on-year increase of 176.1%; In July, the delivery volume of 34,134 vehicles was only 4.7% higher than that of the previous month. The company expects that the number of vehicles delivered in the third quarter will be 100,000 to 103,000, a year-on-year increase of 277.0% to 288.3%.

　　Lin Jiayi, general manager of Xuanjia Fund, told the First Financial Reporter that the growth of LI’s monthly sales slowed down sharply, and the chip loosening and callback were predictable from the perspective of fundamental performance prospects, the continuous deterioration of industry competition and the poor liquidity of the capital market with high interest rates. In the dominant business, the space of family scene is limited, and its short moat may not be stable. The possible expansion of pure electric business is a highly competitive market.

　　Huang Xili, an analyst in soochow securities, said that the delivery in August was higher than that in the previous month, and the steady supply and delivery of vehicles and the continuous growth of terminal orders formed a positive cycle. By the end of August, LI had delivered a total of 208,200 vehicles, up 176.1% year-on-year, and its annual performance was worth looking forward to. In addition, the channel network layout has been accelerated and improved, and the terminal efficiency has been continuously improved.

　　On August 18th, Hang Seng Index Co., Ltd. announced the results of the index review. LI’s share in the Hang Seng Science and Technology Index will be reduced from 9.74% to 8%, and its share with six leading Internet companies will be 8%.

　　At present, most pure tram companies are still mired in losses, and some new forces sell a car, with an average loss of tens of thousands of yuan. However, LI, which has turned losses into profits, has to make efforts in this field to "further broaden the user base and open up incremental markets."

　　"The company plans to launch the 5C pure electric super flagship model in the fourth quarter of 2023, the ideal MEGA. The company is confident that the car will become an explosive model of more than RMB500,000. " LI said in the semi-annual report.

　　"In the new stage of parallel operation of extended-range electric and high-voltage pure electricity, we will continue to improve our research and development capabilities in the fields of intelligence and electrification, optimize our products and expand our product matrix. By 2025, our product matrix is expected to include a super flagship model, five extended-range electric vehicles and five high-voltage pure electric vehicles. " The company also said: "We currently have a manufacturing base in Changzhou, China to produce extended-range vehicles, and are building a manufacturing base in Beijing to actively expand production capacity and prepare for the release of pure electric vehicles."

　　Lin Jiayi believes that in recent days, major car companies are also constantly cutting prices, trying to maintain market share. Under this background, LI’s growth space is facing challenges.

　　Huang Xili said that MEGA is expected to be officially released in December this year, exhibited in stores in January 2024, and delivered by users in February. The launch of MEGA will help LI achieve the goal of being the first luxury car brand in China in 2024.

　　Cui Yan, an analyst at Huaxi Securities, believes that LI’s products should be judged not only by price or body form, but also by what kind of demand the products meet, which stems from the ideal understanding of users’ needs and the extensive demand for family cars. The company has great hope to replicate the success of the extended range series in the pure electric product line to gain greater market share.

　　Car companies whose downstream terminal prices are decreasing are also facing the situation that the upstream raw material prices are rising sharply, which will challenge the gross profit margin: within more than three months since the end of May, major industrial products such as copper and aluminum have risen sharply in three months, and the prices of raw materials have risen in an all-round way. In September, Shanghai Aluminum once approached the 20,000 yuan/ton mark, which caused certain cost pressure on auto parts and vehicle enterprises, especially for electric vehicles, and the demand for aluminum was increasing.